GRLM_DICDI
ID GRLM_DICDI Reviewed; 749 AA.
AC Q54LG8;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=Metabotropic glutamate receptor-like protein M;
DE Flags: Precursor;
GN Name=grlM; ORFNames=DDB_G0286643;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP NOMENCLATURE.
RX PubMed=16735079; DOI=10.1016/j.ejcb.2006.04.003;
RA Prabhu Y., Eichinger L.;
RT "The Dictyostelium repertoire of seven transmembrane domain receptors.";
RL Eur. J. Cell Biol. 85:937-946(2006).
RN [3]
RP DEVELOPMENTAL STAGE.
RX PubMed=17501984; DOI=10.1186/1471-213x-7-44;
RA Prabhu Y., Mueller R., Anjard C., Noegel A.A.;
RT "GrlJ, a Dictyostelium GABAB-like receptor with roles in post-aggregation
RT development.";
RL BMC Dev. Biol. 7:44-44(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Increasingly expressed from early aggregation.
CC {ECO:0000269|PubMed:17501984}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the BMP lipoprotein
CC family. {ECO:0000305}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the G-protein coupled
CC receptor 3 family. GABA-B receptor subfamily. {ECO:0000305}.
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DR EMBL; AAFI02000089; EAL64077.1; -; Genomic_DNA.
DR RefSeq; XP_637593.1; XM_632501.1.
DR AlphaFoldDB; Q54LG8; -.
DR SMR; Q54LG8; -.
DR STRING; 44689.DDB0231990; -.
DR PaxDb; Q54LG8; -.
DR EnsemblProtists; EAL64077; EAL64077; DDB_G0286643.
DR GeneID; 8625733; -.
DR KEGG; ddi:DDB_G0286643; -.
DR dictyBase; DDB_G0286643; grlM.
DR eggNOG; KOG1055; Eukaryota.
DR HOGENOM; CLU_365408_0_0_1; -.
DR InParanoid; Q54LG8; -.
DR OMA; QITYNYA; -.
DR PhylomeDB; Q54LG8; -.
DR PRO; PR:Q54LG8; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR003760; PnrA-like.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF02608; Bmp; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 2: Evidence at transcript level;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Signal; Transducer; Transmembrane; Transmembrane helix.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..749
FT /note="Metabotropic glutamate receptor-like protein M"
FT /id="PRO_0000370356"
FT TOPO_DOM 23..385
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 386..406
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 407..419
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 420..440
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 441..456
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 457..477
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 478..492
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 493..513
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 514..544
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 545..565
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 566..579
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 580..600
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 601..609
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 610..630
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 631..749
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 658..749
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 658..675
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 686..716
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 67
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 164
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 257
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 271
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 345
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 749 AA; 82624 MW; 319A7746BF3B3D9D CRC64;
MIKLILSLIF LIICCNINPS ESFKLITLTT GPTSDLGFNN MVNQGRIGVS KAMNIEDSRI
FIVSGRNETY ALLLPLIQND DIDLVICSSQ DHGDACKEIA AMYIDSPTIK TQFLVRGSGA
ATKNLIQITY NYASVNYISG MFAGLQTVKN KIGFLSPGSA ANNNDSFVYA FWIGAKQVNP
DVKFYYYNIG SYLDQDKTIA ATQDLINIYG CDVIADTLDD FSAGNVAIQN NQYAMGTNGF
PQRDVYGENV IFSYAYNWTK YFLPIAGSVA NGTVPGKWYA DFNKEDNYNF YDLSFGFKVS
QNTKDLLIQK SRVLATTPRA GHPYYCNEYI EQYTKKYNLP TQAANSSCIS TAGFFYINQP
VGDMIYLGSY NIRLSKIEFS SSVQKGFSIV SGCLIAFVIL MMVGIVYYKD TPSIRSASPI
FLNFSLIGGI IIYIGIIIWV GPISTHQCNA RFWLVTLGFS TLIGSLVVKN FRIWLIFDNP
ELKAIKITNY QLFPWVGLCL VINIVLMAIL TSVGDLKAIE AQGIDSLGKY EYMTVCKMNS
AGASTLYSIL AYFAALLLVG VFVSWKIRIV DIEEFNESKA IANTLYAVSF CLFVIVPLMI
SPQEKQSETI ILCVAGLFIT TAALLIVFIP KFWRVFIYGK EGTNEMFKQK KSSSVATARA
ESLSKNSSNG GAHSGGGAVK TNRRGNIVSG DFTDDSESSL SEPNKPTKNN DGNVNVTAGA
VLAEFTDDTI SEFDENEVNE EPVKTESQE
