GRLN_DICDI
ID GRLN_DICDI Reviewed; 891 AA.
AC Q54QG7;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=Metabotropic glutamate receptor-like protein N;
GN Name=grlN; ORFNames=DDB_G0283839;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP NOMENCLATURE.
RX PubMed=16735079; DOI=10.1016/j.ejcb.2006.04.003;
RA Prabhu Y., Eichinger L.;
RT "The Dictyostelium repertoire of seven transmembrane domain receptors.";
RL Eur. J. Cell Biol. 85:937-946(2006).
RN [3]
RP DEVELOPMENTAL STAGE.
RX PubMed=17501984; DOI=10.1186/1471-213x-7-44;
RA Prabhu Y., Mueller R., Anjard C., Noegel A.A.;
RT "GrlJ, a Dictyostelium GABAB-like receptor with roles in post-aggregation
RT development.";
RL BMC Dev. Biol. 7:44-44(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Increasingly expressed from early aggregation.
CC {ECO:0000269|PubMed:17501984}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. GABA-B
CC receptor subfamily. {ECO:0000305}.
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DR EMBL; AAFI02000057; EAL65534.1; -; Genomic_DNA.
DR RefSeq; XP_638904.1; XM_633812.1.
DR AlphaFoldDB; Q54QG7; -.
DR SMR; Q54QG7; -.
DR PaxDb; Q54QG7; -.
DR EnsemblProtists; EAL65534; EAL65534; DDB_G0283839.
DR GeneID; 8624301; -.
DR KEGG; ddi:DDB_G0283839; -.
DR dictyBase; DDB_G0283839; grlN.
DR eggNOG; KOG1055; Eukaryota.
DR HOGENOM; CLU_324261_0_0_1; -.
DR InParanoid; Q54QG7; -.
DR OMA; ITIMFIP; -.
DR PhylomeDB; Q54QG7; -.
DR PRO; PR:Q54QG7; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0031012; C:extracellular matrix; HDA:dictyBase.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR InterPro; IPR017978; GPCR_3_C.
DR Pfam; PF00003; 7tm_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 2: Evidence at transcript level;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..891
FT /note="Metabotropic glutamate receptor-like protein N"
FT /id="PRO_0000370357"
FT TOPO_DOM 1..399
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 400..420
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 421..433
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 434..454
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 455..461
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 462..482
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 483..505
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 506..526
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 527..555
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 556..576
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 577..592
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 593..613
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 614..625
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 626..646
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 647..891
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 52..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 660..689
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 742..827
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 869..891
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 52
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 85
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 88
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 125
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 132
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 224
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 298
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 312
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 320
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 325
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 353
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 363
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 375
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 891 AA; 100650 MW; 2A607875EDE3A1AE CRC64;
MKLYTHKINR IVDGYLDNLN KFGLNYMFEQ DLIKITLDLG IPNNNIKFYN LNNSNSNSNN
NNNNNNNNNN NNNNNNNNNN NNNNNNSNNS NNINNKNDIL YNIIIEEKID LIIFYKSIFS
ENANNISKTF NNLTTIIIND NIISNTNNNN NNNNKFYEIN YPFKISTLLS GYISGLISET
NIIGYLKTNK IQDQTLLDTF YFGARLSNPM VKLMFYTIDY DFKNASNNNF PFQEIIELSV
SSLLKNGVDL ISSSFENNEY LTFCNILLKQ NIKIIGSNGF LISPPLNKDH VLFNSVYNLT
LYILPIISNL INNTNTNNNN NTNNNESTNS QFNINLIFNP SISNLIINNI NSNLSMIENQ
ILNDTNIILT NQLNNESIID LGIISGYILF KPISKTIEYG ITIVSSILIG ALIIIQICII
KYKNKPSFKS ASPTFLIFIV IGGIFVYIGV IIWVSGVNVF TCNAKFWLIS LGLTTMIGGI
VVKNFRIWLI FDNPKLYHIK ITNLQLLPWV LGMFLLNVFL LSLITGLGKL TPFKVFPNDE
KFSSYEIQCE MMDGGLIALY FLLGYFAIIV MIGIFVSWKI RIVDIEEFNE SKSVAYSLYS
IVFCLLIIAP LTISKTGHNT EILCSGFIFI VAAIITIMFI PKFWALKIYG AEGSNEIFRQ
SSSSTSKRKN KSSTTNDPTN LDSISKKSSK NAPKRVNLFL YDFTDDDEES KQSSSSSKGD
TIECMDVFTF IESVQPNSEA ANEMTYNDDP TYTEPSEQPT YTESSEQPNP TPRTLTATPR
TNDLTTPRTN DLTTPRTNDL ITPRTNDLST PRTNDLNTPR TDGILTPRSI NSLATPRVEE
PMSPRQYHNM MITLSPILEE ENIVVVEKDE VIENSDSESE SSDSNSDSII Q
