GRLP_DICDI
ID GRLP_DICDI Reviewed; 1407 AA.
AC Q54F54;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Metabotropic glutamate receptor-like protein P;
GN Name=grlP; ORFNames=DDB_G0291095;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP NOMENCLATURE.
RX PubMed=16735079; DOI=10.1016/j.ejcb.2006.04.003;
RA Prabhu Y., Eichinger L.;
RT "The Dictyostelium repertoire of seven transmembrane domain receptors.";
RL Eur. J. Cell Biol. 85:937-946(2006).
RN [3]
RP DEVELOPMENTAL STAGE.
RX PubMed=17501984; DOI=10.1186/1471-213x-7-44;
RA Prabhu Y., Mueller R., Anjard C., Noegel A.A.;
RT "GrlJ, a Dictyostelium GABAB-like receptor with roles in post-aggregation
RT development.";
RL BMC Dev. Biol. 7:44-44(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Increased levels found from the tight aggregation
CC stage onward. Levels stayed high during late development. Clear
CC expression at 24 hours when fruiting body formation is close to
CC completion. {ECO:0000269|PubMed:17501984}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. GABA-B
CC receptor subfamily. {ECO:0000305}.
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DR EMBL; AAFI02000175; EAL61895.1; -; Genomic_DNA.
DR RefSeq; XP_635400.1; XM_630308.1.
DR AlphaFoldDB; Q54F54; -.
DR SMR; Q54F54; -.
DR STRING; 44689.DDB0231723; -.
DR PaxDb; Q54F54; -.
DR EnsemblProtists; EAL61895; EAL61895; DDB_G0291095.
DR GeneID; 8627984; -.
DR KEGG; ddi:DDB_G0291095; -.
DR dictyBase; DDB_G0291095; grlP.
DR eggNOG; KOG1055; Eukaryota.
DR HOGENOM; CLU_253936_0_0_1; -.
DR InParanoid; Q54F54; -.
DR OMA; TITHYCS; -.
DR PhylomeDB; Q54F54; -.
DR Reactome; R-DDI-418594; G alpha (i) signalling events.
DR Reactome; R-DDI-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
DR Reactome; R-DDI-977444; GABA B receptor activation.
DR PRO; PR:Q54F54; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0038039; C:G protein-coupled receptor heterodimeric complex; IBA:GO_Central.
DR GO; GO:0004965; F:G protein-coupled GABA receptor activity; IBA:GO_Central.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
DR GO; GO:0007214; P:gamma-aminobutyric acid signaling pathway; IBA:GO_Central.
DR Gene3D; 2.160.20.10; -; 1.
DR InterPro; IPR002455; GPCR3_GABA-B.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR012334; Pectin_lyas_fold.
DR InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR PANTHER; PTHR10519; PTHR10519; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR SUPFAM; SSF51126; SSF51126; 2.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Repeat; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..1407
FT /note="Metabotropic glutamate receptor-like protein P"
FT /id="PRO_0000370359"
FT TOPO_DOM 1..696
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 697..717
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 718..731
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 732..752
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 753..758
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 759..779
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 780..806
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 807..827
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 828..853
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 854..874
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 875..890
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 891..911
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 912..919
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 920..940
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 941..1407
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 93..118
FT /note="PbH1 1"
FT REPEAT 129..150
FT /note="PbH1 2"
FT REPEAT 254..279
FT /note="PbH1 3"
FT REPEAT 452..476
FT /note="PbH1 4"
FT REGION 991..1072
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1084..1248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1267..1351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1369..1407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1315..1344
FT /evidence="ECO:0000255"
FT COMPBIAS 991..1070
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1093..1219
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1227..1248
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1274..1351
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 43
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 58
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 162
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 179
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 182
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 230
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 241
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 270
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 368
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 391
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 464
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 512
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 539
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 544
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 554
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 571
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 627
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 646
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1407 AA; 155811 MW; 3B53774B8937754F CRC64;
MKFKKKNIYW VSPTKGVESM GCGLVKEFPC KDIGSIIDKI TPNVSTIINL MEGVYRGNFS
YLMTNFVILF KGEGRDKTII DLEGRQRFTL CTISDIHFKD LTIKNGFGNA ISGIFDGGAI
YAYDSQIHFV NVALIDNTCS ASGGGIFLYN CYFNVEHSLF QNNTANSGGG FILLLSASNI
TNSSFLHNRV FQEGKGGAIQ VFISFMSIEL SLFAYNIAPY SGAIDMVGGN LTSKYSKFIE
NHSNIGGGFG LYFISNVIFE SCEFIGNRAN STGGLSFLTA QSMLRFSLCI FKDNFAPNCG
IVESHSISPL LFESCSFTGD VPTAVQIALY DNYCFLKVQN CHFSEIQGVL MYADSISNII
IDSSSFTNVS NRIIDVGNEA DILIISSTFY NITIDEYLVS LSNGNFLAYN MDFNNNIVLA
LIKSSVGGSV TIVSSSMSNN YVSTSLISLS NGYSVYIENC EVKNNTGLFK GCFIDTDHTG
SETIVQSLFE NNRSPFGPIL YFSNPETMLS TNYSSNFRDI LFSNNFAAYS GALVYFSQNV
SLPNISCTNC IYDNNTAVFG ELVNSAFYSF NVSITPVIYP FQDLIIEIFA LDFFGNLVRG
TSDLGFFAIP CSDAYVEGNL FAVLNENGSA IFSNIKLSSN PNSICNLTFL SVPIVSENGP
ITIPITFSYC SQDRELVMIK SIYYCLKTIK VTSFVKFLVG TLAAILLIIL IISGFISLKY
RKKRVIRYSN PLFLCIILVG CIIFLITIPV LFGSTSATCK IRFPIIVIGS CLVTSSVFIK
QFRIWRLIKD IQLLRETNVE NKYLLKFISI LMVIPIIIVI CSFFIFPTHE KYTFNQRDIT
ITHYCSDGSY LAYVIIFLVY QMAILLFGCY LVIVCRKFRS IPGTFNEATY IGILIYNYTV
VLIVAIPLAY VFNKNPLANF LIFSISIIVF VLSTIILLFI PKFHFLLRKK VIISSLEKLI
KEQEAIVQRN KDILYFYDMY LAEERTGIQQ QQRQGNLYNN NSLGRSISSN TRKRSNNNIN
NNNNNNSFNM TGFSDSSSTI SNPNLTSFTS SPSSLNSSSD SDSTPDFNDP NFLEYYNERV
KNYGKRKSIE KNKINNSIPN SPKSTTSLPT SLPSSSSSSS SSSSSSSSSS SSSSSSSSIT
PKSNTPILSP SSQSSKTINK GGSGSGNSSS IPNYQNIKSP NTPKSNKSSP NLSIPVNKNS
KVSKLSSNQI SSPKSIKSDK SPITIKDFDN SSDLSDSSNS LKSDSSIGSE QFNEKVINRI
FNIHQDKKVK TTKQQSDSTL SSIGSDSSPN FNENINNPNI NPNNNNNPNN NNNNNNNNNN
NNNNNNNINN NNNNANNNNS DTDDSSPNFN ENIEKKNVVK TKTNFLNQFH QKKQKDSDNR
KNYNISPINI SDEKVPPLSP INLSKRK
