GRLQ_DICDI
ID GRLQ_DICDI Reviewed; 1187 AA.
AC Q54K09;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 14-APR-2009, sequence version 2.
DT 25-MAY-2022, entry version 71.
DE RecName: Full=Metabotropic glutamate receptor-like protein Q;
GN Name=grlQ; ORFNames=DDB_G0287905;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP NOMENCLATURE.
RX PubMed=16735079; DOI=10.1016/j.ejcb.2006.04.003;
RA Prabhu Y., Eichinger L.;
RT "The Dictyostelium repertoire of seven transmembrane domain receptors.";
RL Eur. J. Cell Biol. 85:937-946(2006).
RN [3]
RP DEVELOPMENTAL STAGE.
RX PubMed=17501984; DOI=10.1186/1471-213x-7-44;
RA Prabhu Y., Mueller R., Anjard C., Noegel A.A.;
RT "GrlJ, a Dictyostelium GABAB-like receptor with roles in post-aggregation
RT development.";
RL BMC Dev. Biol. 7:44-44(2007).
RN [4]
RP INDUCTION [LARGE SCALE ANALYSIS].
RX PubMed=18590548; DOI=10.1186/1471-2180-8-109;
RA Carilla-Latorre S., Calvo-Garrido J., Bloomfield G., Skelton J., Kay R.R.,
RA Ivens A., Martinez J.L., Escalante R.;
RT "Dictyostelium transcriptional responses to Pseudomonas aeruginosa: common
RT and specific effects from PAO1 and PA14 strains.";
RL BMC Microbiol. 8:109-109(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Increasingly expressed from early aggregation.
CC {ECO:0000269|PubMed:17501984}.
CC -!- INDUCTION: Up-regulated by P.aeruginosa, PAO1 strain and PA14 strain
CC infection. {ECO:0000269|PubMed:18590548}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. GABA-B
CC receptor subfamily. {ECO:0000305}.
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DR EMBL; AAFI02000104; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAFI02000103; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; Q54K09; -.
DR dictyBase; DDB_G0287905; grlQ.
DR InParanoid; Q54K09; -.
DR OMA; PGTFYES; -.
DR PhylomeDB; Q54K09; -.
DR Reactome; R-DDI-418594; G alpha (i) signalling events.
DR Reactome; R-DDI-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
DR Reactome; R-DDI-977444; GABA B receptor activation.
DR PRO; PR:Q54K09; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0038039; C:G protein-coupled receptor heterodimeric complex; IBA:GO_Central.
DR GO; GO:0004965; F:G protein-coupled GABA receptor activity; IBA:GO_Central.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
DR GO; GO:0007214; P:gamma-aminobutyric acid signaling pathway; IBA:GO_Central.
DR Gene3D; 2.160.20.10; -; 1.
DR InterPro; IPR002455; GPCR3_GABA-B.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR012334; Pectin_lyas_fold.
DR InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR PANTHER; PTHR10519; PTHR10519; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR SUPFAM; SSF51126; SSF51126; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 2: Evidence at transcript level;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..1187
FT /note="Metabotropic glutamate receptor-like protein Q"
FT /id="PRO_0000370360"
FT TOPO_DOM 1..735
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 736..756
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 757..768
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 769..789
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 790..796
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 797..817
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 818..843
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 844..864
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 865..888
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 889..909
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 910..925
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 926..946
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 947..955
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 956..976
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 977..1095
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1074..1187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1074..1110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1125..1178
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 35
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 44
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 55
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 177
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 258
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 275
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 397
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 402
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 462
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 526
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 527
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 557
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 562
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 684
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 794
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1187 AA; 134886 MW; 37B0966F92127673 CRC64;
MRLFFKFFYL SNEGFDNELC GNFKSPCKNI GYLFNNSRVD KNFNSTFYFS PGIYNLSSSI
IIIDFQVGIN LIGIGENKKI IITTHKGTRG VISYNSNLII RGITFDNCKV KKNEFPLYVP
ETLTDYSDDK LDYLTLNYYI GTGGALQIVY SKVYISNCVF SNNKGRNGGA IFTVLSNITI
SDCIFYSNQA LMRSEDGGNG GAIFFGLSTN AIILKSIFKN NMAITGGVIV QSNSELRVED
TVFAYNQASN GGVFLIFNDS KIESTRCSFY ANYANISAIA NIQNSFAFQK SCLYQENMAS
AMGGVFSLVD RTILFVTLSI FNDNYAPSSL IVENHGSGLA MFTNCEFTFS DNFKRQIIQS
LFSISNYNFL LLKDSRVSNS KGNVIWCTSN AIIVVYNTTF YNVSSKVINI HSQGYFFSIS
TTFIECKAED YLVVLRNGAR GILFRNNFID NNGILMVFTT YNSSMIIIES KFFNNIVRNE
LIAVRNEYTL QIYNSIFKNN IGKTRGCIIS VDQLGKLTST NNYFINNTSV YGTIINFVKK
RFNYWHTDFQ CFSTFKNDTI VNNTALVSGA IVYYRDKIIG TKYTCESCLF LNNIAHFGNN
INSGFHSFSV IQASKVHSNE HFPALIYAFD QFDNLIRGKN DIRFHVSSCD DIHLTGVTSS
TIQLNGVTAL YNLKVNSPEN HFCNLSYKSN PKKGDVKLPI SILNCPQGEE MFDVSYQGKV
FQCLKTIETS NIAKTVMIIT TSILVLLILL CFGITIAYSK EKVINFGNIV FLILMLFSCL
FLCIIIYVSI EPTNFSCQFS AIVFPIGIGI LFTLTLLKQY KIYKLFKYSD FLKINTDNLK
MVKYAGLIMV PVFLLVLIGV IVYPSKPTFI LDLHTKTATK YCISRKYYVF SIVIVVYEVI
ILLTSCFIAM KSKRYHSTPG TFYESLFNSI LIYNYTLVFI VLIPLFYTLQ NNPTTIYLIY
SIGSSILVFA TLSIIFIPKI NFLFRRKQIV STLKKTIETQ ERDIQRNKDL LIFYKMFLIE
KKNNNFNNNP IFNIHETFSS EDEDEDEEDD IGEGIYSLFN HWDQNKRKYN NNQIYPNQIP
KQTTNSPSSQ SIDFLNNPTI PKNKSINNLP NLFKKPKKKL KSKIISKSAN SSPNINNNTI
NNNNNNNNNN NNNNNNNNNN NNINNNNNNN ININTKRRKS MDPSLDS
