GRM2B_MOUSE
ID GRM2B_MOUSE Reviewed; 445 AA.
AC Q6PEM6; E9Q8C6;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=GRAM domain-containing protein 2B;
DE AltName: Full=GRAM domain-containing protein 3;
GN Name=Gramd2b; Synonyms=Gramd3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-238; SER-255 AND SER-265, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
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DR EMBL; AC120797; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC162035; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC057978; AAH57978.1; -; mRNA.
DR CCDS; CCDS89243.1; -.
DR RefSeq; XP_006525557.1; XM_006525494.1.
DR AlphaFoldDB; Q6PEM6; -.
DR SMR; Q6PEM6; -.
DR BioGRID; 223187; 1.
DR STRING; 10090.ENSMUSP00000068453; -.
DR iPTMnet; Q6PEM6; -.
DR PhosphoSitePlus; Q6PEM6; -.
DR jPOST; Q6PEM6; -.
DR MaxQB; Q6PEM6; -.
DR PaxDb; Q6PEM6; -.
DR PRIDE; Q6PEM6; -.
DR ProteomicsDB; 269637; -.
DR Antibodypedia; 2140; 216 antibodies from 25 providers.
DR Ensembl; ENSMUST00000237422; ENSMUSP00000157609; ENSMUSG00000001700.
DR UCSC; uc008eyk.1; mouse.
DR MGI; MGI:1914815; Gramd3.
DR VEuPathDB; HostDB:ENSMUSG00000001700; -.
DR eggNOG; KOG1032; Eukaryota.
DR GeneTree; ENSGT00940000156980; -.
DR InParanoid; Q6PEM6; -.
DR OrthoDB; 944155at2759; -.
DR BioGRID-ORCS; 107022; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Gramd3; mouse.
DR PRO; PR:Q6PEM6; -.
DR Proteomes; UP000000589; Chromosome 18.
DR RNAct; Q6PEM6; protein.
DR Bgee; ENSMUSG00000001700; Expressed in small intestine Peyer's patch and 237 other tissues.
DR ExpressionAtlas; Q6PEM6; baseline and differential.
DR GO; GO:0005881; C:cytoplasmic microtubule; ISS:UniProtKB.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR011993; PH-like_dom_sf.
DR Pfam; PF02893; GRAM; 1.
DR SMART; SM00568; GRAM; 1.
PE 1: Evidence at protein level;
KW Acetylation; Phosphoprotein; Reference proteome.
FT CHAIN 1..445
FT /note="GRAM domain-containing protein 2B"
FT /id="PRO_0000087578"
FT DOMAIN 123..190
FT /note="GRAM"
FT REGION 1..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 233..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 277..331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..43
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..93
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..114
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 233..250
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 277..311
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q96HH9"
FT MOD_RES 238
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 255
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 265
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CONFLICT 232
FT /note="N -> K (in Ref. 2; AAH57978)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 445 AA; 49272 MW; B06E579CA0095E0A CRC64;
MVKKRLSSSD NVFKFEIPSN SKTSAEAPHS STDSPSSVFL SSEAENGAED RRRVSKSPTA
QSPTSSVEAE SPDQKRSLGL WSKSSFDGSS LLSDKNDCKT ESKTDSKTER KKSSSSSQYK
ANMHFHKLFL DVPTEEPLRQ SFTCALQKEI LYQGKLFVSE NWICFHSKVF GKDTKISIPA
FSVTLIKKTK TALLVPNALI IATVTDRYIF VSLLSRDSTY KLIKSVCGHL ENTSVGNSPN
PSSAENSFRA DRPSSLPLDF NDEFSDLDGV VRQRRQDLEG YSSSGSQTPE SENSRDFHVT
ESQTVLNVTK GETKPPRTDA HGSRAPDGKA KILPAHGQSE TIGILHKMES RKCPTLHHIL
IVYAIIVCAL IISTFYMRYR INTLEERLGT LTSIMDPHST EQTAPSGLGS QMQLNVEVLC
QELTANIVKL EKIQNNLQKL LENGD
