AMPD1_CHICK
ID AMPD1_CHICK Reviewed; 26 AA.
AC P81073;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=AMP deaminase 1;
DE EC=3.5.4.6;
DE AltName: Full=AMP deaminase isoform M;
DE AltName: Full=Myoadenylate deaminase;
DE Flags: Fragment;
GN Name=AMPD1;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP PROTEIN SEQUENCE.
RC TISSUE=Mammary gland;
RX PubMed=9114497; DOI=10.1016/s0305-0491(96)00270-2;
RA Chilson O.P., Kelly-Chilson A.E., Siegel N.R.;
RT "AMP-deaminases from chicken and rabbit muscle: partial primary sequences
RT of homologous 17-kDa CNBr fragments: autorecognition by rabbit anti-
RT [chicken AMPD].";
RL Comp. Biochem. Physiol. 116B:371-377(1997).
CC -!- FUNCTION: AMP deaminase plays a critical role in energy metabolism.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=AMP + H(+) + H2O = IMP + NH4(+); Xref=Rhea:RHEA:14777,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:58053, ChEBI:CHEBI:456215; EC=3.5.4.6;
CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via salvage pathway; IMP
CC from AMP: step 1/1.
CC -!- SUBUNIT: Homotetramer.
CC -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC Adenosine and AMP deaminases family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; P81073; -.
DR STRING; 9031.ENSGALP00000003242; -.
DR PaxDb; P81073; -.
DR eggNOG; KOG1096; Eukaryota.
DR HOGENOM; CLU_003782_4_0_1; -.
DR InParanoid; P81073; -.
DR OrthoDB; 49756at2759; -.
DR BRENDA; 3.5.4.6; 1306.
DR UniPathway; UPA00591; UER00663.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0003876; F:AMP deaminase activity; IEA:UniProtKB-EC.
DR GO; GO:0032264; P:IMP salvage; IEA:UniProtKB-UniPathway.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Hydrolase; Nucleotide metabolism;
KW Reference proteome.
FT CHAIN <1..>26
FT /note="AMP deaminase 1"
FT /id="PRO_0000194406"
FT NON_TER 1
FT NON_TER 26
SQ SEQUENCE 26 AA; 3195 MW; B03E296D63BB6E75 CRC64;
MNQKHLLRFI KKSYRVDADR VVYDAK