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AMPD1_CHICK
ID   AMPD1_CHICK             Reviewed;          26 AA.
AC   P81073;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=AMP deaminase 1;
DE            EC=3.5.4.6;
DE   AltName: Full=AMP deaminase isoform M;
DE   AltName: Full=Myoadenylate deaminase;
DE   Flags: Fragment;
GN   Name=AMPD1;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Mammary gland;
RX   PubMed=9114497; DOI=10.1016/s0305-0491(96)00270-2;
RA   Chilson O.P., Kelly-Chilson A.E., Siegel N.R.;
RT   "AMP-deaminases from chicken and rabbit muscle: partial primary sequences
RT   of homologous 17-kDa CNBr fragments: autorecognition by rabbit anti-
RT   [chicken AMPD].";
RL   Comp. Biochem. Physiol. 116B:371-377(1997).
CC   -!- FUNCTION: AMP deaminase plays a critical role in energy metabolism.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=AMP + H(+) + H2O = IMP + NH4(+); Xref=Rhea:RHEA:14777,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:58053, ChEBI:CHEBI:456215; EC=3.5.4.6;
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via salvage pathway; IMP
CC       from AMP: step 1/1.
CC   -!- SUBUNIT: Homotetramer.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenosine and AMP deaminases family. {ECO:0000305}.
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DR   AlphaFoldDB; P81073; -.
DR   STRING; 9031.ENSGALP00000003242; -.
DR   PaxDb; P81073; -.
DR   eggNOG; KOG1096; Eukaryota.
DR   HOGENOM; CLU_003782_4_0_1; -.
DR   InParanoid; P81073; -.
DR   OrthoDB; 49756at2759; -.
DR   BRENDA; 3.5.4.6; 1306.
DR   UniPathway; UPA00591; UER00663.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0003876; F:AMP deaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0032264; P:IMP salvage; IEA:UniProtKB-UniPathway.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hydrolase; Nucleotide metabolism;
KW   Reference proteome.
FT   CHAIN           <1..>26
FT                   /note="AMP deaminase 1"
FT                   /id="PRO_0000194406"
FT   NON_TER         1
FT   NON_TER         26
SQ   SEQUENCE   26 AA;  3195 MW;  B03E296D63BB6E75 CRC64;
     MNQKHLLRFI KKSYRVDADR VVYDAK
 
 
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