ID   GRN2_CYPCA              Reviewed;          57 AA.
AC   P81014;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Granulin-2;
OS   Cyprinus carpio (Common carp).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Cyprininae; Cyprinus.
OX   NCBI_TaxID=7962;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Kidney;
RX   PubMed=8486624; DOI=10.1016/s0021-9258(18)98340-7;
RA   Belcourt D.R., Lazure C., Bennett H.P.;
RT   "Isolation and primary structure of the three major forms of granulin-like
RT   peptides from hematopoietic tissues of a teleost fish (Cyprinus carpio).";
RL   J. Biol. Chem. 268:9230-9237(1993).
CC   -!- FUNCTION: Granulins have possible cytokine-like activity. They may play
CC       a role in inflammation, wound repair, and tissue remodeling.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Ubiquitous.
CC   -!- PTM: Granulins are disulfide bridged.
CC   -!- SIMILARITY: Belongs to the granulin family. {ECO:0000305}.
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DR   PIR; B46654; B46654.
DR   AlphaFoldDB; P81014; -.
DR   SMR; P81014; -.
DR   PRIDE; P81014; -.
DR   Proteomes; UP000694384; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.25.160; -; 1.
DR   InterPro; IPR000118; Granulin.
DR   InterPro; IPR039036; Granulin_fam.
DR   InterPro; IPR037277; Granulin_sf.
DR   PANTHER; PTHR12274; PTHR12274; 1.
DR   Pfam; PF00396; Granulin; 1.
DR   SMART; SM00277; GRAN; 1.
PE   1: Evidence at protein level;
KW   Cytokine; Direct protein sequencing; Disulfide bond; Reference proteome;
KW   Secreted.
FT   CHAIN           1..57
FT                   /note="Granulin-2"
FT                   /id="PRO_0000150131"
FT   DISULFID        4..16
FT                   /evidence="ECO:0000250"
FT   DISULFID        10..26
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   57 AA;  6536 MW;  CE81711AED039C44 CRC64;
     VVYCNARTTC PSRTTCCRSP FGVWYCCPFL MGQCCRDGRH CCRHGYRCDS TSTLCLR