ID   GRN_DICDI               Reviewed;         130 AA.
AC   Q54QR7;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Granulin;
DE   Flags: Precursor;
GN   Name=grn; ORFNames=DDB_G0283671;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- PTM: Granulins are disulfide bridged. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the granulin family. {ECO:0000305}.
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DR   EMBL; AAFI02000056; EAL65602.1; -; Genomic_DNA.
DR   RefSeq; XP_638956.1; XM_633864.1.
DR   AlphaFoldDB; Q54QR7; -.
DR   STRING; 44689.DDB0238428; -.
DR   PaxDb; Q54QR7; -.
DR   EnsemblProtists; EAL65602; EAL65602; DDB_G0283671.
DR   GeneID; 8624196; -.
DR   KEGG; ddi:DDB_G0283671; -.
DR   dictyBase; DDB_G0283671; grn.
DR   eggNOG; KOG4296; Eukaryota.
DR   HOGENOM; CLU_1942028_0_0_1; -.
DR   InParanoid; Q54QR7; -.
DR   OMA; DGSYACC; -.
DR   PhylomeDB; Q54QR7; -.
DR   PRO; PR:Q54QR7; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.10.25.160; -; 1.
DR   InterPro; IPR000118; Granulin.
DR   InterPro; IPR039036; Granulin_fam.
DR   InterPro; IPR037277; Granulin_sf.
DR   PANTHER; PTHR12274; PTHR12274; 1.
DR   Pfam; PF00396; Granulin; 1.
DR   SMART; SM00277; GRAN; 1.
DR   PROSITE; PS00799; GRANULINS; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..130
FT                   /note="Granulin"
FT                   /id="PRO_0000386629"
FT   DISULFID        67..79
FT                   /evidence="ECO:0000250"
FT   DISULFID        73..89
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   130 AA;  14278 MW;  5AAC23141C580E8A CRC64;
     MNYSKIFIFG IISLILMALF SSTVESVSLK NLKIKNNNNN NNNIENKHKT KKSLELTETQ
     DFGSVKCPDG SLCPNSNTCC SASDGSYACC PTPNAQCCSD KQHCCPYQFT CGNGGNICKP
     QQGLRFSFNR