ID   GRO1_RABIT              Reviewed;          71 AA.
AC   P30782;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 2.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Permeability factor 2;
DE   AltName: Full=RPF2;
DE   Flags: Fragment;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=New Zealand white; TISSUE=Alveolar macrophage;
RX   PubMed=7828903; DOI=10.1016/0378-1119(94)90684-x;
RA   Johnson M.C., Goodman R.B. II, Kajikawa O., Wong V.A., Mongovin S.M.,
RA   Martin T.R.;
RT   "Cloning of two rabbit GRO homologues and their expression in alveolar
RT   macrophages.";
RL   Gene 151:337-338(1994).
RN   [2]
RP   PROTEIN SEQUENCE OF 1-36.
RC   STRAIN=New Zealand white; TISSUE=Peritoneal cavity;
RX   PubMed=1898341; DOI=10.1042/bj2780493;
RA   Jose P.J., Collins P.D., Perkins J.A., Beaubien B.C., Totty N.F.,
RA   Waterfield M.D., Hsuan J., Williams T.J.;
RT   "Identification of a second neutrophil-chemoattractant cytokine generated
RT   during an inflammatory reaction in the rabbit peritoneal cavity in vivo.
RT   Purification, partial amino acid sequence and structural relationship to
RT   melanoma-growth-stimulatory activity.";
RL   Biochem. J. 278:493-497(1991).
CC   -!- FUNCTION: Has chemotactic activity for neutrophils. {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- INDUCTION: Generated during an inflammatory reaction.
CC   -!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family.
CC       {ECO:0000305}.
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DR   EMBL; L19157; AAA64357.1; -; mRNA.
DR   AlphaFoldDB; P30782; -.
DR   SMR; P30782; -.
DR   STRING; 9986.ENSOCUP00000024741; -.
DR   eggNOG; ENOG502S7MM; Eukaryota.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0008009; F:chemokine activity; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   CDD; cd00273; Chemokine_CXC; 1.
DR   InterPro; IPR001089; Chemokine_CXC.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR033899; CXC_Chemokine_domain.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR10179; PTHR10179; 1.
DR   Pfam; PF00048; IL8; 1.
DR   PRINTS; PR00437; SMALLCYTKCXC.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; SSF54117; 1.
PE   1: Evidence at protein level;
KW   Cytokine; Direct protein sequencing; Disulfide bond; Growth factor;
KW   Inflammatory response; Reference proteome; Secreted.
FT   CHAIN           1..>71
FT                   /note="Permeability factor 2"
FT                   /id="PRO_0000144296"
FT   DISULFID        7..33
FT                   /evidence="ECO:0000250"
FT   DISULFID        9..49
FT                   /evidence="ECO:0000250"
FT   CONFLICT        20
FT                   /note="N -> S (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        23
FT                   /note="N -> S (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   NON_TER         71
SQ   SEQUENCE   71 AA;  7713 MW;  E91387CB382C8008 CRC64;
     ALTELRCQCL QTVQGIHLKN IQNLKVLSPG PHCAQTEVIA TLKSGQEACR NPAAPMVKKF
     LQKRLSNGNS S