ID   GRO2_RABIT              Reviewed;         104 AA.
AC   P47854;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Growth-regulated protein homolog;
DE            Short=GRO homolog;
DE   Flags: Precursor;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Schwartz D., Chaverri-Alamada L., Berliner J., Kirchgessner T.,
RA   Quisomoro D., Fang J., Tekamp-Olson P., Lusis J., Fogelman A., Territo M.;
RL   Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in monocyte adhesion to the endothelium.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family.
CC       {ECO:0000305}.
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DR   EMBL; U12310; AAA20487.1; -; mRNA.
DR   RefSeq; NP_001075811.1; NM_001082342.1.
DR   AlphaFoldDB; P47854; -.
DR   SMR; P47854; -.
DR   PRIDE; P47854; -.
DR   GeneID; 100009192; -.
DR   KEGG; ocu:100009192; -.
DR   CTD; 100009192; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0008009; F:chemokine activity; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   CDD; cd00273; Chemokine_CXC; 1.
DR   InterPro; IPR001089; Chemokine_CXC.
DR   InterPro; IPR018048; Chemokine_CXC_CS.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR033899; CXC_Chemokine_domain.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR10179; PTHR10179; 1.
DR   Pfam; PF00048; IL8; 1.
DR   PRINTS; PR00437; SMALLCYTKCXC.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; SSF54117; 1.
DR   PROSITE; PS00471; SMALL_CYTOKINES_CXC; 1.
PE   3: Inferred from homology;
KW   Cytokine; Disulfide bond; Growth factor; Inflammatory response;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000305"
FT   CHAIN           32..104
FT                   /note="Growth-regulated protein homolog"
FT                   /id="PRO_0000005056"
FT   DISULFID        40..66
FT                   /evidence="ECO:0000250"
FT   DISULFID        42..82
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   104 AA;  10900 MW;  10B9D07B65C77F67 CRC64;
     MAPAATAAAP RLLRAALLLL LLVAAGRRAA GAPVVNELRC QCLQTLQGIH LKNIQSVKVT
     TPGPHCDQTE VIASLKTGQE VCLNPTAPVV KKIIDKMLNK ASAN