ID   GROA_BOVIN              Reviewed;         104 AA.
AC   O46676;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Growth-regulated protein homolog alpha;
DE            Short=GRO-alpha;
DE   Flags: Precursor;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10028286; DOI=10.1093/oxfordjournals.molbev.a026101;
RA   Modi W.S., Yoshimura T.;
RT   "Isolation of novel GRO genes and a phylogenetic analysis of the CXC
RT   chemokine subfamily in mammals.";
RL   Mol. Biol. Evol. 16:180-193(1999).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U95812; AAB93928.1; -; mRNA.
DR   PIR; S50035; S50035.
DR   RefSeq; NP_783631.1; NM_175700.1.
DR   AlphaFoldDB; O46676; -.
DR   SMR; O46676; -.
DR   GeneID; 281212; -.
DR   KEGG; bta:281212; -.
DR   CTD; 281212; -.
DR   OrthoDB; 1617719at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
DR   GO; GO:0045236; F:CXCR chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IBA:GO_Central.
DR   GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
DR   GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR   CDD; cd00273; Chemokine_CXC; 1.
DR   InterPro; IPR001089; Chemokine_CXC.
DR   InterPro; IPR018048; Chemokine_CXC_CS.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR033899; CXC_Chemokine_domain.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR10179; PTHR10179; 1.
DR   Pfam; PF00048; IL8; 1.
DR   PRINTS; PR00437; SMALLCYTKCXC.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; SSF54117; 1.
DR   PROSITE; PS00471; SMALL_CYTOKINES_CXC; 1.
PE   3: Inferred from homology;
KW   Cytokine; Disulfide bond; Growth factor; Inflammatory response;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000255"
FT   CHAIN           31..104
FT                   /note="Growth-regulated protein homolog alpha"
FT                   /id="PRO_0000005058"
FT   DISULFID        40..66
FT                   /evidence="ECO:0000250"
FT   DISULFID        42..82
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   104 AA;  10984 MW;  1002CAC064DB1F76 CRC64;
     MAPAATAAAP RLLRAAMLFL LLVAAGRRAA GAPVVNELRC QCLQTLQGIH LKNIQSVKVT
     TPGPHCDQTE VIASLKTGQE VCLNPTAPMV KKIIDKMLNK ASAN