ID   GROA_CAVPO              Reviewed;         104 AA.
AC   O55235;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Growth-regulated alpha protein;
DE   AltName: Full=C-X-C motif chemokine 1;
DE   Flags: Precursor;
GN   Name=CXCL1; Synonyms=GRO, SCYB1;
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=NIH 2;
RX   PubMed=10394101; DOI=10.1159/000024184;
RA   Yoshimura T., Takeya M., Ogata H., Yamashiro S., Modi W.S., Gillitzer R.;
RT   "Molecular cloning of the guinea pig GRO gene and its rapid expression in
RT   the tissues of lipopolysaccharide-injected guinea pigs.";
RL   Int. Arch. Allergy Immunol. 119:101-111(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC   STRAIN=Hartley; TISSUE=Spleen;
RA   Yoshimura T., Takeya M., Ogata H., Gillitzer R.;
RT   "Genomic structure of the guinea pig GRO gene and its expression in the
RT   lungs of LPS-injected guinea pigs.";
RL   Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Has chemotactic activity for neutrophils.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family.
CC       {ECO:0000305}.
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DR   EMBL; U95809; AAB93925.1; -; mRNA.
DR   EMBL; U95810; AAB93926.1; -; mRNA.
DR   EMBL; AF052004; AAC06227.1; -; mRNA.
DR   EMBL; AF052005; AAC06228.1; -; Genomic_DNA.
DR   RefSeq; NP_001166409.1; NM_001172938.1.
DR   AlphaFoldDB; O55235; -.
DR   SMR; O55235; -.
DR   STRING; 10141.ENSCPOP00000013707; -.
DR   Ensembl; ENSCPOT00000023735; ENSCPOP00000015321; ENSCPOG00000015206.
DR   GeneID; 100135510; -.
DR   KEGG; cpoc:100135510; -.
DR   CTD; 2919; -.
DR   eggNOG; ENOG502S7MM; Eukaryota.
DR   GeneTree; ENSGT00940000155233; -.
DR   HOGENOM; CLU_143902_1_1_1; -.
DR   InParanoid; O55235; -.
DR   OMA; EKMLNCD; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   Bgee; ENSCPOG00000015206; Expressed in liver and 11 other tissues.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0008009; F:chemokine activity; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   CDD; cd00273; Chemokine_CXC; 1.
DR   InterPro; IPR001089; Chemokine_CXC.
DR   InterPro; IPR018048; Chemokine_CXC_CS.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR033899; CXC_Chemokine_domain.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR10179; PTHR10179; 1.
DR   Pfam; PF00048; IL8; 1.
DR   PRINTS; PR00437; SMALLCYTKCXC.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; SSF54117; 1.
DR   PROSITE; PS00471; SMALL_CYTOKINES_CXC; 1.
PE   3: Inferred from homology;
KW   Cytokine; Disulfide bond; Growth factor; Inflammatory response;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000255"
FT   CHAIN           32..104
FT                   /note="Growth-regulated alpha protein"
FT                   /id="PRO_0000005047"
FT   DISULFID        40..66
FT                   /evidence="ECO:0000250"
FT   DISULFID        42..82
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   104 AA;  11069 MW;  DAFD96D9F4041D5A CRC64;
     MAGAAPKTLR FAPLLLLLLL LVLGTSRRAA GAPAASELRC RCLRPVRGLH PKNIQSVAVT
     APGPHCHQTE VLATLKDGRE ACLDPEAPMV QKVLQRMLKG SKAT