ID   GROA_CRIGR              Reviewed;         101 AA.
AC   P09340;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Growth-regulated alpha protein;
DE   AltName: Full=C-X-C motif chemokine 1;
DE   Flags: Precursor;
GN   Name=CXCL1; Synonyms=GRO, SCYB1;
OS   Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2890161; DOI=10.1073/pnas.84.20.7188;
RA   Anisowicz A., Bardwell L., Sager R.;
RT   "Constitutive overexpression of a growth-regulated gene in transformed
RT   Chinese hamster and human cells.";
RL   Proc. Natl. Acad. Sci. U.S.A. 84:7188-7192(1987).
CC   -!- FUNCTION: Has chemotactic activity for neutrophils.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family.
CC       {ECO:0000305}.
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DR   EMBL; J03560; AAA36985.1; -; mRNA.
DR   PIR; B28414; B28414.
DR   RefSeq; NP_001230973.1; NM_001244044.1.
DR   AlphaFoldDB; P09340; -.
DR   SMR; P09340; -.
DR   STRING; 10029.NP_001230973.1; -.
DR   GeneID; 100689059; -.
DR   KEGG; cge:100689059; -.
DR   CTD; 2919; -.
DR   eggNOG; ENOG502S7MM; Eukaryota.
DR   OrthoDB; 1617719at2759; -.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0008009; F:chemokine activity; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   CDD; cd00273; Chemokine_CXC; 1.
DR   InterPro; IPR001089; Chemokine_CXC.
DR   InterPro; IPR018048; Chemokine_CXC_CS.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR033899; CXC_Chemokine_domain.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR10179; PTHR10179; 1.
DR   Pfam; PF00048; IL8; 1.
DR   PRINTS; PR00437; SMALLCYTKCXC.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; SSF54117; 1.
DR   PROSITE; PS00471; SMALL_CYTOKINES_CXC; 1.
PE   3: Inferred from homology;
KW   Cytokine; Disulfide bond; Growth factor; Inflammatory response; Secreted;
KW   Signal.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..101
FT                   /note="Growth-regulated alpha protein"
FT                   /id="PRO_0000005048"
FT   DISULFID        37..63
FT                   /evidence="ECO:0000250"
FT   DISULFID        39..79
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   101 AA;  10893 MW;  666FB7E9CC512019 CRC64;
     MAPATRSLLR APLLLLLLLL ATSRLATGAP VANELRCQCL QTMTGVHLKN IQSLKVTPPG
     PHCTQTEVIA TLKNGQEACL NPEAPMVQKI VQKMLKSGIR K