ID   GROA_SHEEP              Reviewed;         103 AA.
AC   O46678;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Growth-regulated alpha protein;
DE   AltName: Full=C-X-C motif chemokine 1;
DE   Flags: Precursor;
GN   Name=CXCL1; Synonyms=GRO, SCYB1;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10028286; DOI=10.1093/oxfordjournals.molbev.a026101;
RA   Modi W.S., Yoshimura T.;
RT   "Isolation of novel GRO genes and a phylogenetic analysis of the CXC
RT   chemokine subfamily in mammals.";
RL   Mol. Biol. Evol. 16:180-193(1999).
CC   -!- FUNCTION: Has chemotactic activity for neutrophils.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family.
CC       {ECO:0000305}.
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DR   EMBL; U95814; AAB93930.1; -; mRNA.
DR   RefSeq; NP_001009358.1; NM_001009358.1.
DR   AlphaFoldDB; O46678; -.
DR   SMR; O46678; -.
DR   STRING; 9940.ENSOARP00000015847; -.
DR   Ensembl; ENSOART00020004532; ENSOARP00020003729; ENSOARG00020002942.
DR   GeneID; 443380; -.
DR   KEGG; oas:443380; -.
DR   CTD; 2919; -.
DR   eggNOG; ENOG502S7MM; Eukaryota.
DR   OrthoDB; 1617719at2759; -.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0008009; F:chemokine activity; IEA:InterPro.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   CDD; cd00273; Chemokine_CXC; 1.
DR   InterPro; IPR001089; Chemokine_CXC.
DR   InterPro; IPR018048; Chemokine_CXC_CS.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR033899; CXC_Chemokine_domain.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR10179; PTHR10179; 1.
DR   Pfam; PF00048; IL8; 1.
DR   PRINTS; PR00437; SMALLCYTKCXC.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; SSF54117; 1.
DR   PROSITE; PS00471; SMALL_CYTOKINES_CXC; 1.
PE   3: Inferred from homology;
KW   Cytokine; Disulfide bond; Growth factor; Inflammatory response;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000255"
FT   CHAIN           31..103
FT                   /note="Growth-regulated alpha protein"
FT                   /id="PRO_0000005057"
FT   DISULFID        39..65
FT                   /evidence="ECO:0000250"
FT   DISULFID        41..81
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   103 AA;  10820 MW;  C59857F346716695 CRC64;
     MARAANPAPR LLGAAMLLLL LVAAGRRAAG APVVNELRCQ CLQTVQGIHL KNMQSVKVTP
     PGPHCGQTEV IATLKTGQEV CLNPAAPMVK KIIDKMLNQA SSN