ID   GROG_BOVIN              Reviewed;          98 AA.
AC   O46675;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Growth-regulated protein homolog gamma;
DE            Short=GRO-gamma;
DE   Flags: Precursor;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10028286; DOI=10.1093/oxfordjournals.molbev.a026101;
RA   Modi W.S., Yoshimura T.;
RT   "Isolation of novel GRO genes and a phylogenetic analysis of the CXC
RT   chemokine subfamily in mammals.";
RL   Mol. Biol. Evol. 16:180-193(1999).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family.
CC       {ECO:0000305}.
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DR   EMBL; U95811; AAB93927.1; -; mRNA.
DR   RefSeq; NP_776724.1; NM_174299.3.
DR   RefSeq; XP_005208119.1; XM_005208062.3.
DR   AlphaFoldDB; O46675; -.
DR   SMR; O46675; -.
DR   STRING; 9913.ENSBTAP00000039327; -.
DR   PaxDb; O46675; -.
DR   Ensembl; ENSBTAT00000039536; ENSBTAP00000039327; ENSBTAG00000027513.
DR   GeneID; 281214; -.
DR   KEGG; bta:281214; -.
DR   CTD; 2920; -.
DR   VEuPathDB; HostDB:ENSBTAG00000027513; -.
DR   eggNOG; ENOG502S7MM; Eukaryota.
DR   GeneTree; ENSGT00940000155233; -.
DR   HOGENOM; CLU_143902_1_0_1; -.
DR   InParanoid; O46675; -.
DR   OMA; PHCSNLE; -.
DR   OrthoDB; 1618797at2759; -.
DR   TreeFam; TF333433; -.
DR   Reactome; R-BTA-6798695; Neutrophil degranulation.
DR   Proteomes; UP000009136; Chromosome 6.
DR   Bgee; ENSBTAG00000027513; Expressed in intramuscular adipose tissue and 57 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
DR   GO; GO:0045236; F:CXCR chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; IBA:GO_Central.
DR   GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
DR   GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR   CDD; cd00273; Chemokine_CXC; 1.
DR   InterPro; IPR001089; Chemokine_CXC.
DR   InterPro; IPR018048; Chemokine_CXC_CS.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   InterPro; IPR033899; CXC_Chemokine_domain.
DR   InterPro; IPR036048; Interleukin_8-like_sf.
DR   PANTHER; PTHR10179; PTHR10179; 1.
DR   Pfam; PF00048; IL8; 1.
DR   PRINTS; PR00437; SMALLCYTKCXC.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; SSF54117; 1.
DR   PROSITE; PS00471; SMALL_CYTOKINES_CXC; 1.
PE   3: Inferred from homology;
KW   Cytokine; Disulfide bond; Growth factor; Inflammatory response;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..98
FT                   /note="Growth-regulated protein homolog gamma"
FT                   /id="PRO_0000005060"
FT   DISULFID        39..65
FT                   /evidence="ECO:0000250"
FT   DISULFID        41..81
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   98 AA;  10393 MW;  942CD6897C21EDE9 CRC64;
     MAPAASSAPR LLRAAMLLLL LVAAGRRAAG APVVNELRCQ CLQTLQGIHL KNIQSVKVTT
     PGPHCDQTEV IATLKTGQEV CLNPAAPMVK KIIDKMLN