ID   AMPD1_RABIT             Reviewed;          26 AA.
AC   P81072;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=AMP deaminase 1;
DE            EC=3.5.4.6;
DE   AltName: Full=AMP deaminase isoform M;
DE   AltName: Full=Myoadenylate deaminase;
DE   Flags: Fragment;
GN   Name=AMPD1;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=9114497; DOI=10.1016/s0305-0491(96)00270-2;
RA   Chilson O.P., Kelly-Chilson A.E., Siegel N.R.;
RT   "AMP-deaminases from chicken and rabbit muscle: partial primary sequences
RT   of homologous 17-kDa CNBr fragments: autorecognition by rabbit anti-
RT   [chicken AMPD].";
RL   Comp. Biochem. Physiol. 116B:371-377(1997).
CC   -!- FUNCTION: AMP deaminase plays a critical role in energy metabolism.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=AMP + H(+) + H2O = IMP + NH4(+); Xref=Rhea:RHEA:14777,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:58053, ChEBI:CHEBI:456215; EC=3.5.4.6;
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000250};
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via salvage pathway; IMP
CC       from AMP: step 1/1.
CC   -!- SUBUNIT: Homotetramer.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenosine and AMP deaminases family. {ECO:0000305}.
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DR   AlphaFoldDB; P81072; -.
DR   STRING; 9986.ENSOCUP00000014118; -.
DR   ChEMBL; CHEMBL2242733; -.
DR   eggNOG; KOG1096; Eukaryota.
DR   InParanoid; P81072; -.
DR   BRENDA; 3.5.4.6; 1749.
DR   UniPathway; UPA00591; UER00663.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0003876; F:AMP deaminase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0032264; P:IMP salvage; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR006329; AMPD.
DR   Pfam; PF19326; AMP_deaminase; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hydrolase; Metal-binding; Nucleotide metabolism;
KW   Reference proteome; Zinc.
FT   CHAIN           <1..>26
FT                   /note="AMP deaminase 1"
FT                   /id="PRO_0000194404"
FT   NON_TER         1
FT   NON_TER         26
SQ   SEQUENCE   26 AA;  3169 MW;  B022467EACBB6E75 CRC64;
     MNQKHLLRFI KKSYQVDADR VVYSTK