GRP1_PINMA
ID GRP1_PINMA Reviewed; 423 AA.
AC P86966;
DT 19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT 19-OCT-2011, sequence version 1.
DT 02-JUN-2021, entry version 12.
DE RecName: Full=Glycine-rich protein 1;
DE AltName: Full=Nacre uncharacterized shell protein 4;
DE Short=NUSP4;
DE Flags: Precursor; Fragment;
OS Pinctada maxima (Silver-lipped pearl oyster) (White-lipped pearl oyster).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Pterioida; Pterioidea; Pteriidae; Pinctada.
OX NCBI_TaxID=104660;
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA], AND IDENTIFICATION.
RC TISSUE=Mantle {ECO:0000269|PubMed:19915030};
RX PubMed=19915030; DOI=10.1093/molbev/msp278;
RA Jackson D.J., McDougall C., Woodcroft B., Moase P., Rose R.A., Kube M.,
RA Reinhardt R., Rokhsar D.S., Montagnani C., Joubert C., Piquemal D.,
RA Degnan B.M.;
RT "Parallel evolution of nacre building gene sets in molluscs.";
RL Mol. Biol. Evol. 27:591-608(2010).
RN [2]
RP PROTEIN SEQUENCE OF 24-35, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC TISSUE=Shell;
RX PubMed=23213212; DOI=10.1073/pnas.1210552109;
RA Marie B., Joubert C., Tayale A., Zanella-Cleon I., Belliard C.,
RA Piquemal D., Cochennec-Laureau N., Marin F., Gueguen Y., Montagnani C.;
RT "Different secretory repertoires control the biomineralization processes of
RT prism and nacre deposition of the pearl oyster shell.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:20986-20991(2012).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23213212}.
CC -!- TISSUE SPECIFICITY: Nacreous layer of shell (at protein level).
CC {ECO:0000269|PubMed:23213212}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EZ420205; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=GT279245; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; GT277781; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT278277; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT279245; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT279877; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT281073; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT281112; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT282648; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT283139; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT283279; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT284077; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; EZ420205; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; EZ420206; -; NOT_ANNOTATED_CDS; mRNA.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..423
FT /note="Glycine-rich protein 1"
FT /evidence="ECO:0000255"
FT /id="PRO_0000413072"
FT REGION 78..132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 154..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 236..288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..113
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..180
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 254..285
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 76
FT /note="N -> D (in Ref. 1; GT279877/GT277781)"
FT /evidence="ECO:0000305"
FT CONFLICT 97
FT /note="T -> S (in Ref. 1; GT283279)"
FT /evidence="ECO:0000305"
FT CONFLICT 149
FT /note="N -> K (in Ref. 1; GT279877/GT277781)"
FT /evidence="ECO:0000305"
FT CONFLICT 181..182
FT /note="SG -> FS (in Ref. 1; GT282648)"
FT /evidence="ECO:0000305"
FT CONFLICT 182
FT /note="G -> S (in Ref. 1; GT279877)"
FT /evidence="ECO:0000305"
FT CONFLICT 196
FT /note="G -> R (in Ref. 1; GT279877)"
FT /evidence="ECO:0000305"
FT CONFLICT 198
FT /note="G -> R (in Ref. 1; GT279877)"
FT /evidence="ECO:0000305"
FT CONFLICT 201
FT /note="A -> P (in Ref. 1; GT279877)"
FT /evidence="ECO:0000305"
FT CONFLICT 217
FT /note="A -> T (in Ref. 1; GT278277)"
FT /evidence="ECO:0000305"
FT CONFLICT 225
FT /note="A -> T (in Ref. 1; GT278277)"
FT /evidence="ECO:0000305"
FT CONFLICT 229
FT /note="A -> T (in Ref. 1; GT278277)"
FT /evidence="ECO:0000305"
FT CONFLICT 233
FT /note="A -> T (in Ref. 1; GT278277)"
FT /evidence="ECO:0000305"
FT CONFLICT 235
FT /note="A -> P (in Ref. 1; GT278277)"
FT /evidence="ECO:0000305"
FT CONFLICT 237
FT /note="A -> T (in Ref. 1; GT278277)"
FT /evidence="ECO:0000305"
FT CONFLICT 366
FT /note="A -> V (in Ref. 1; GT279245)"
FT /evidence="ECO:0000305"
FT CONFLICT 372..373
FT /note="SS -> IF (in Ref. 1; GT279245)"
FT /evidence="ECO:0000305"
FT NON_TER 423
FT /evidence="ECO:0000305"
SQ SEQUENCE 423 AA; 38266 MW; 7E9DCC7D2C5ACAC6 CRC64;
MKKICLTFVF LLSLFPIYSS QNKQAAGTIE SGSSKSSGSS VGNAGPATPE FKSYKEEFSY
WYTYYSVYYD VLNALNDDDD NKDKKKNDED GKTETITSAK KQNGDDVKSD NSKSTAIKKS
GGGKTDGEAS KKNNSANSWK IILKLLGFNV VDKENGNGKG GSANNGGEGG ATSAGSAGAT
SGAGANGGDA GETEAGEGNG ASSDGAGGES GGAGAGAGAG AGAGAGGGAG AGAGAGASAG
AGAGGAQGDA EAASAGSTAG STSSGGAAAS GASSGAGSSD SGQGASAGGA AAGASAASAA
GGGGAAIGGS ASAASGSAAS SGSSAGASAA ASGSAAGGNK FTKLIKIVQM ASMMGGVENL
MENPLALQMI MSSSGASAGA SAAGSSAAGS SAAGAGGGAG AAGAAGASAX AGAGAGASAR
AGV
