GRP1_USTMA
ID GRP1_USTMA Reviewed; 175 AA.
AC A0A0D1C8Z4; A0A0D1CTT4;
DT 23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2015, sequence version 1.
DT 03-AUG-2022, entry version 28.
DE RecName: Full=Glycine-rich RNA-binding protein 1 {ECO:0000303|PubMed:30552148};
GN Name=GRP1 {ECO:0000303|PubMed:30552148}; ORFNames=UMAG_02412;
OS Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Ustilago.
OX NCBI_TaxID=237631;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=521 / FGSC 9021;
RX PubMed=17080091; DOI=10.1038/nature05248;
RA Kaemper J., Kahmann R., Boelker M., Ma L.-J., Brefort T., Saville B.J.,
RA Banuett F., Kronstad J.W., Gold S.E., Mueller O., Perlin M.H.,
RA Woesten H.A.B., de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G.,
RA Snetselaar K., McCann M., Perez-Martin J., Feldbruegge M., Basse C.W.,
RA Steinberg G., Ibeas J.I., Holloman W., Guzman P., Farman M.L.,
RA Stajich J.E., Sentandreu R., Gonzalez-Prieto J.M., Kennell J.C., Molina L.,
RA Schirawski J., Mendoza-Mendoza A., Greilinger D., Muench K., Roessel N.,
RA Scherer M., Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B.,
RA Meng S., Ho E.C.H., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J.,
RA Deelstra H.J., Ortiz-Castellanos L., Li W., Sanchez-Alonso P.,
RA Schreier P.H., Haeuser-Hahn I., Vaupel M., Koopmann E., Friedrich G.,
RA Voss H., Schlueter T., Margolis J., Platt D., Swimmer C., Gnirke A.,
RA Chen F., Vysotskaia V., Mannhaupt G., Gueldener U., Muensterkoetter M.,
RA Haase D., Oesterheld M., Mewes H.-W., Mauceli E.W., DeCaprio D., Wade C.M.,
RA Butler J., Young S.K., Jaffe D.B., Calvo S.E., Nusbaum C., Galagan J.E.,
RA Birren B.W.;
RT "Insights from the genome of the biotrophic fungal plant pathogen Ustilago
RT maydis.";
RL Nature 444:97-101(2006).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=521 / FGSC 9021;
RA Gueldener U., Muensterkoetter M., Walter M.C., Mannhaupt G., Kahmann R.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP FUNCTION, DISRUPTION PHENOTYPE, SUBUNIT, SUBCELLULAR LOCATION, AND
RP MRNA-BINDING.
RX PubMed=30552148; DOI=10.15252/embr.201846588;
RA Olgeiser L., Haag C., Boerner S., Ule J., Busch A., Koepke J., Koenig J.,
RA Feldbruegge M., Zarnack K.;
RT "The key protein of endosomal mRNP transport Rrm4 binds translational
RT landmark sites of cargo mRNAs.";
RL EMBO Rep. 20:0-0(2019).
CC -!- FUNCTION: Component of endosomal mRNA transport that regulates polarity
CC of the infectious hyphae by transporting a broad spectrum of cargo
CC mRNAs from the nucleus to cell poles. {ECO:0000269|PubMed:30552148}.
CC -!- SUBUNIT: Part of large ribonucleoprotein complexes (mRNPs) containing
CC RNA-binding proteins RRM4 and PAB1, endosome-binding protein UPA1, core
CC scaffold protein UPA2 and associated factor GRP1.
CC {ECO:0000269|PubMed:30552148}.
CC -!- SUBCELLULAR LOCATION: Endosome {ECO:0000269|PubMed:30552148}. Note=The
CC endosomal localization of GRP1 depends on RRM4.
CC {ECO:0000269|PubMed:30552148}.
CC -!- DISRUPTION PHENOTYPE: In the yeast form, results in slower
CC proliferation as well as increased cell size (PubMed:30552148). Does
CC not cause an increased amount of bipolar cells and leads to
CC significantly longer hyphae and empty sections at the basal pole
CC (PubMed:30552148). {ECO:0000269|PubMed:30552148}.
CC -!- SIMILARITY: Belongs to the glycine-rich RNA-binding protein family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=KIS69898.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; CM003144; KIS69898.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CM003144; KIS69897.1; -; Genomic_DNA.
DR RefSeq; XP_011388704.1; XM_011390402.1.
DR RefSeq; XP_011388705.1; XM_011390403.1.
DR STRING; 5270.UM02412P0; -.
DR EnsemblFungi; KIS69897; KIS69897; UMAG_02412.
DR EnsemblFungi; KIS69898; KIS69898; UMAG_02412.
DR GeneID; 23563163; -.
DR KEGG; uma:UMAG_02412; -.
DR VEuPathDB; FungiDB:UMAG_02412; -.
DR eggNOG; KOG0118; Eukaryota.
DR OMA; GWEDRSY; -.
DR OrthoDB; 1579773at2759; -.
DR Proteomes; UP000000561; Chromosome 5.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 1: Evidence at protein level;
KW Endosome; mRNA transport; Reference proteome; RNA-binding; Transport.
FT CHAIN 1..175
FT /note="Glycine-rich RNA-binding protein 1"
FT /id="PRO_0000454343"
FT DOMAIN 3..81
FT /note="RRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 114..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..153
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 175 AA; 18115 MW; 73F24B76655FA661 CRC64;
MAAKVYVGNL SWNTTDDSLA HAFSTYGQLT DYIVMKDRET GRSRGFGFVT FATQAEADAA
IAALNEQELD GRRIRVNMAN SRPAGGMGGG YGGVTGQYGA NAYGAQGGYG GYGGQPGGFQ
QPGGFQQQGG YPQQGGYGGY QQPGFQPQQG GYGAPQQGYG APQQGGYGGY NGQSQ