ID   GRPB_RAT                Reviewed;         247 AA.
AC   P08462;
DT   01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1988, sequence version 1.
DT   25-MAY-2022, entry version 108.
DE   RecName: Full=Submandibular gland secretory Glx-rich protein CB;
DE            Short=GRP-CB;
DE   AltName: Full=Contiguous repeat polypeptide;
DE            Short=CRP;
DE   Flags: Precursor;
GN   Name=Grpcb;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RX   PubMed=3558393; DOI=10.1016/s0021-9258(18)61183-4;
RA   Heinrich G., Habener J.F.;
RT   "Genes encoding proteins with homologous contiguous repeat sequences are
RT   highly expressed in the serous cells of the rat submandibular gland.";
RL   J. Biol. Chem. 262:5262-5270(1987).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Wistar;
RX   PubMed=1995617; DOI=10.1016/s0021-9258(19)67828-2;
RA   Cooper L.F., Elia D.M., Tabak L.A.;
RT   "Secretagogue-coupled changes in the expression of glutamine/glutamic acid-
RT   rich proteins (GRPs). Isoproterenol induces changes in GRP transcript
RT   expression and changes in isoforms secreted.";
RL   J. Biol. Chem. 266:3532-3539(1991).
CC   -!- FUNCTION: GRP proteins have a marked affinity for hydroxyapatite. They
CC       may play a role in the formation of the protective acquired pellicle at
CC       the saliva-tooth interface.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Submandibular gland acinar cells.
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DR   EMBL; M31032; AAA40969.1; -; mRNA.
DR   EMBL; M58654; AAA41279.1; ALT_SEQ; mRNA.
DR   PIR; A29545; A29545.
DR   PIR; B38647; B38647.
DR   RefSeq; NP_852105.1; NM_181440.1.
DR   RefSeq; NP_976077.1; NM_203332.1.
DR   AlphaFoldDB; P08462; -.
DR   STRING; 10116.ENSRNOP00000007659; -.
DR   PRIDE; P08462; -.
DR   GeneID; 192266; -.
DR   GeneID; 360395; -.
DR   KEGG; rno:360395; -.
DR   UCSC; RGD:735181; rat.
DR   CTD; 11272; -.
DR   CTD; 5554; -.
DR   RGD; 735181; Grpcb.
DR   OrthoDB; 327524at32523; -.
DR   PRO; PR:P08462; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0031214; P:biomineral tissue development; IEA:UniProtKB-KW.
DR   InterPro; IPR026086; Pro-rich.
DR   PANTHER; PTHR23203; PTHR23203; 4.
DR   Pfam; PF15240; Pro-rich; 1.
DR   SMART; SM01412; Pro-rich; 1.
PE   2: Evidence at transcript level;
KW   Biomineralization; Reference proteome; Repeat; Secreted; Signal.
FT   SIGNAL          1..18
FT   CHAIN           19..247
FT                   /note="Submandibular gland secretory Glx-rich protein CB"
FT                   /id="PRO_0000013037"
FT   REPEAT          67..89
FT                   /note="1"
FT   REPEAT          90..112
FT                   /note="2"
FT   REPEAT          113..135
FT                   /note="3"
FT   REPEAT          136..158
FT                   /note="4"
FT   REPEAT          159..181
FT                   /note="5"
FT   REGION          14..219
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          67..181
FT                   /note="5 X 23 AA tandem repeats"
FT   COMPBIAS        14..44
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        72..196
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        202..216
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   247 AA;  26948 MW;  72A5075BCCC314E4 CRC64;
     MLVVLLTAAL LALSSAQGTD EEVNNAETSD VPADSEQQPV DSGSDPPSAD ADAENVQEGE
     SAPPANEEPP ATSGSEEEQQ QQEPTQAENQ EPPATSGSEE EQQQQEPTQA ENQEPPATSG
     SEEEQQQQQP TQAENQEPPA TSGSEEEQQQ QESTQAENQE PSDSAGEGQE TQPEEGNVES
     PPSSPENSQE QPQQTNPEEK PPAPKTQEEP QHYRGRPPKK IFPFFIYRGR PVVVFRLEPR
     NPFARRF