ID   GRPE_CAEEL              Reviewed;         237 AA.
AC   Q18421;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 145.
DE   RecName: Full=GrpE protein homolog, mitochondrial;
DE   Flags: Precursor;
GN   ORFNames=C34C12.8;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Essential component of the PAM complex, a complex required
CC       for the translocation of transit peptide-containing proteins from the
CC       inner membrane into the mitochondrial matrix in an ATP-dependent
CC       manner. Seems to control the nucleotide-dependent binding of
CC       mitochondrial HSP70 to substrate proteins (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Probable component of the PAM complex at least composed of a
CC       mitochondrial HSP70 protein, GrpE, tim-44, tim-16 and tim-14/dnj-21.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GrpE family. {ECO:0000305}.
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DR   EMBL; Z46996; CAA87101.1; -; Genomic_DNA.
DR   PIR; T19702; T19702.
DR   RefSeq; NP_497713.1; NM_065312.4.
DR   AlphaFoldDB; Q18421; -.
DR   SMR; Q18421; -.
DR   BioGRID; 40691; 33.
DR   DIP; DIP-26028N; -.
DR   STRING; 6239.C34C12.8; -.
DR   World-2DPAGE; 0020:Q18421; -.
DR   EPD; Q18421; -.
DR   PaxDb; Q18421; -.
DR   PeptideAtlas; Q18421; -.
DR   EnsemblMetazoa; C34C12.8.1; C34C12.8.1; WBGene00007927.
DR   GeneID; 175449; -.
DR   KEGG; cel:CELE_C34C12.8; -.
DR   UCSC; C34C12.8; c. elegans.
DR   CTD; 175449; -.
DR   WormBase; C34C12.8; CE03057; WBGene00007927; -.
DR   eggNOG; KOG3003; Eukaryota.
DR   GeneTree; ENSGT00390000005589; -.
DR   HOGENOM; CLU_057217_0_1_1; -.
DR   InParanoid; Q18421; -.
DR   OMA; PVGHIEV; -.
DR   OrthoDB; 1525208at2759; -.
DR   PhylomeDB; Q18421; -.
DR   PRO; PR:Q18421; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00007927; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0005739; C:mitochondrion; HDA:WormBase.
DR   GO; GO:0001405; C:PAM complex, Tim23 associated import motor; IBA:GO_Central.
DR   GO; GO:0000774; F:adenyl-nucleotide exchange factor activity; IBA:GO_Central.
DR   GO; GO:0051087; F:chaperone binding; IEA:InterPro.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR   GO; GO:0006457; P:protein folding; IEA:InterPro.
DR   GO; GO:0030150; P:protein import into mitochondrial matrix; IBA:GO_Central.
DR   CDD; cd00446; GrpE; 1.
DR   Gene3D; 2.30.22.10; -; 1.
DR   Gene3D; 3.90.20.20; -; 1.
DR   HAMAP; MF_01151; GrpE; 1.
DR   InterPro; IPR000740; GrpE.
DR   InterPro; IPR013805; GrpE_coiled_coil.
DR   InterPro; IPR009012; GrpE_head.
DR   PANTHER; PTHR21237; PTHR21237; 1.
DR   Pfam; PF01025; GrpE; 1.
DR   PRINTS; PR00773; GRPEPROTEIN.
DR   SUPFAM; SSF51064; SSF51064; 1.
DR   SUPFAM; SSF58014; SSF58014; 1.
DR   PROSITE; PS01071; GRPE; 1.
PE   3: Inferred from homology;
KW   Chaperone; Mitochondrion; Reference proteome; Transit peptide.
FT   TRANSIT         1..?
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           ?..237
FT                   /note="GrpE protein homolog, mitochondrial"
FT                   /id="PRO_0000013047"
SQ   SEQUENCE   237 AA;  26448 MW;  24C160D76ADD2A26 CRC64;
     MLRKGVSFVG QAVQQTLKTQ KNLRIQRFSA TASQSSEEVN YEIRKDGKRL RGADYEEIVL
     TSIAGEDKTQ IPKGAFDVLL KEYDDLQAES LDFKDKYQRS LAETENVRRR GIKQTDDAKV
     FAIQSFCKDL LEVSDILDIA VKSVKPEDLE SGGKALKDLF EGVSMTRTVM AKTFAKHGLV
     TVDPTNEKFD PNLHEAVFQI PSANAKQPVG HIEVCTKIGY SLKERPIRPA QVGVVSK