ID   GRPE_CHLTR              Reviewed;         190 AA.
AC   P36424; O84400;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 2.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=Protein GrpE {ECO:0000255|HAMAP-Rule:MF_01151};
DE   AltName: Full=HSP-70 cofactor {ECO:0000255|HAMAP-Rule:MF_01151};
GN   Name=grpE {ECO:0000255|HAMAP-Rule:MF_01151}; OrderedLocusNames=CT_395;
OS   Chlamydia trachomatis (strain D/UW-3/Cx).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=272561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=E/UW-5/Cx;
RX   PubMed=8045424; DOI=10.1016/0378-1119(94)90322-0;
RA   Schmiel D.H., Wyrick P.B.;
RT   "Another putative heat-shock gene and aminoacyl-tRNA synthetase gene are
RT   located upstream from the grpE-like and dnaK-like genes in Chlamydia
RT   trachomatis.";
RL   Gene 145:57-63(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=D/UW-3/Cx;
RX   PubMed=9784136; DOI=10.1126/science.282.5389.754;
RA   Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L.,
RA   Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.;
RT   "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia
RT   trachomatis.";
RL   Science 282:754-759(1998).
CC   -!- FUNCTION: Participates actively in the response to hyperosmotic and
CC       heat shock by preventing the aggregation of stress-denatured proteins,
CC       in association with DnaK and GrpE. It is the nucleotide exchange factor
CC       for DnaK and may function as a thermosensor. Unfolded proteins bind
CC       initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK
CC       hydrolyzes its bound ATP, resulting in the formation of a stable
CC       complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the
CC       release of the substrate protein, thus completing the reaction cycle.
CC       Several rounds of ATP-dependent interactions between DnaJ, DnaK and
CC       GrpE are required for fully efficient folding. {ECO:0000255|HAMAP-
CC       Rule:MF_01151}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01151}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01151}.
CC   -!- SIMILARITY: Belongs to the GrpE family. {ECO:0000255|HAMAP-
CC       Rule:MF_01151}.
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DR   EMBL; L25105; AAA23163.1; -; Genomic_DNA.
DR   EMBL; AE001273; AAC67992.1; -; Genomic_DNA.
DR   PIR; A71521; A71521.
DR   RefSeq; NP_219905.1; NC_000117.1.
DR   RefSeq; WP_009872625.1; NC_000117.1.
DR   AlphaFoldDB; P36424; -.
DR   SMR; P36424; -.
DR   STRING; 813.O172_02150; -.
DR   EnsemblBacteria; AAC67992; AAC67992; CT_395.
DR   GeneID; 884720; -.
DR   KEGG; ctr:CT_395; -.
DR   PATRIC; fig|272561.5.peg.425; -.
DR   HOGENOM; CLU_057217_5_2_0; -.
DR   InParanoid; P36424; -.
DR   OMA; YAYEKIA; -.
DR   Proteomes; UP000000431; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000774; F:adenyl-nucleotide exchange factor activity; IBA:GO_Central.
DR   GO; GO:0051087; F:chaperone binding; IEA:InterPro.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:InterPro.
DR   GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR   GO; GO:0006457; P:protein folding; IEA:InterPro.
DR   CDD; cd00446; GrpE; 1.
DR   Gene3D; 2.30.22.10; -; 1.
DR   Gene3D; 3.90.20.20; -; 1.
DR   HAMAP; MF_01151; GrpE; 1.
DR   InterPro; IPR000740; GrpE.
DR   InterPro; IPR013805; GrpE_coiled_coil.
DR   InterPro; IPR009012; GrpE_head.
DR   PANTHER; PTHR21237; PTHR21237; 1.
DR   Pfam; PF01025; GrpE; 1.
DR   PRINTS; PR00773; GRPEPROTEIN.
DR   SUPFAM; SSF51064; SSF51064; 1.
DR   SUPFAM; SSF58014; SSF58014; 1.
DR   PROSITE; PS01071; GRPE; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Reference proteome; Stress response.
FT   CHAIN           1..190
FT                   /note="Protein GrpE"
FT                   /id="PRO_0000113771"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         80
FT                   /note="P -> S (in strain: E/UW-5/Cx)"
FT   VARIANT         185
FT                   /note="S -> G (in strain: E/UW-5/Cx)"
SQ   SEQUENCE   190 AA;  21668 MW;  9BB97B8F44AD92B5 CRC64;
     MTETPNTSSE EIQTSEPSPD NELQVLQQEN ANLKAELQEQ NDRYLMALAE AENSRKRLQK
     ERTEMMQYAV ENALMDFLPP IESMEKALGF ASQTSEEVKN WAIGFQMILQ QFKQIFEEKG
     VVEYSSKGEL FNPYLHEAVE IEETTTIPEG TILEEFTKGY KIGDRPIRVA KVKVAKLPAK
     GNSDSNEEKE