GRPL2_HUMAN
ID GRPL2_HUMAN Reviewed; 344 AA.
AC Q4G1C9; Q6MZS1; Q8N6N0; Q8NA43;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 2.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=GLIPR1-like protein 2;
GN Name=GLIPR1L2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Lymph node;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1-308 (ISOFORM 1).
RC TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP ALTERNATIVE SPLICING (ISOFORMS 1; 2; 4; 5 AND 6), TISSUE SPECIFICITY, AND
RP INDUCTION BY DOXYCYCLINE.
RX PubMed=16714093; DOI=10.1016/j.ygeno.2006.03.021;
RA Ren C., Ren C.-H., Li L., Goltsov A.A., Thompson T.C.;
RT "Identification and characterization of RTVP1/GLIPR1-like genes, a novel
RT p53 target gene cluster.";
RL Genomics 88:163-172(2006).
CC -!- INTERACTION:
CC Q4G1C9-2; P16284: PECAM1; NbExp=3; IntAct=EBI-20835942, EBI-716404;
CC Q4G1C9-2; P61086: UBE2K; NbExp=3; IntAct=EBI-20835942, EBI-473850;
CC Q4G1C9-2; P08670: VIM; NbExp=3; IntAct=EBI-20835942, EBI-353844;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=6;
CC Name=1; Synonyms=delta;
CC IsoId=Q4G1C9-1; Sequence=Displayed;
CC Name=2; Synonyms=alpha;
CC IsoId=Q4G1C9-2; Sequence=VSP_032246;
CC Name=3;
CC IsoId=Q4G1C9-3; Sequence=VSP_032242, VSP_032243;
CC Name=4; Synonyms=epsilon;
CC IsoId=Q4G1C9-4; Sequence=VSP_032244, VSP_032245;
CC Name=5; Synonyms=gamma;
CC IsoId=Q4G1C9-5; Sequence=VSP_032239;
CC Name=6; Synonyms=beta;
CC IsoId=Q4G1C9-6; Sequence=VSP_032240, VSP_032241;
CC -!- TISSUE SPECIFICITY: Highly expressed in testis. Detected in prostate,
CC kidney, bladder, lung and bone marrow. {ECO:0000269|PubMed:16714093}.
CC -!- INDUCTION: Up-regulated by doxycycline. {ECO:0000269|PubMed:16714093}.
CC -!- SIMILARITY: Belongs to the CRISP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH16749.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
CC Sequence=BAC04085.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
CC Sequence=CAE45957.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK093175; BAC04085.1; ALT_SEQ; mRNA.
DR EMBL; BX640916; CAE45957.1; ALT_INIT; mRNA.
DR EMBL; AC121761; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471054; EAW97305.1; -; Genomic_DNA.
DR EMBL; BC016749; AAH16749.1; ALT_SEQ; mRNA.
DR EMBL; BC029557; AAH29557.1; -; mRNA.
DR CCDS; CCDS58258.1; -. [Q4G1C9-1]
DR CCDS; CCDS9010.1; -. [Q4G1C9-2]
DR RefSeq; NP_001257325.1; NM_001270396.1. [Q4G1C9-1]
DR RefSeq; NP_689649.1; NM_152436.2. [Q4G1C9-2]
DR RefSeq; XP_011536251.1; XM_011537949.2. [Q4G1C9-5]
DR RefSeq; XP_011536252.1; XM_011537950.2. [Q4G1C9-5]
DR RefSeq; XP_016874338.1; XM_017018849.1. [Q4G1C9-5]
DR AlphaFoldDB; Q4G1C9; -.
DR SMR; Q4G1C9; -.
DR BioGRID; 126842; 23.
DR IntAct; Q4G1C9; 12.
DR STRING; 9606.ENSP00000448248; -.
DR iPTMnet; Q4G1C9; -.
DR PhosphoSitePlus; Q4G1C9; -.
DR BioMuta; GLIPR1L2; -.
DR DMDM; 172046790; -.
DR EPD; Q4G1C9; -.
DR MassIVE; Q4G1C9; -.
DR PaxDb; Q4G1C9; -.
DR PeptideAtlas; Q4G1C9; -.
DR PRIDE; Q4G1C9; -.
DR ProteomicsDB; 62160; -. [Q4G1C9-1]
DR ProteomicsDB; 62161; -. [Q4G1C9-2]
DR ProteomicsDB; 62162; -. [Q4G1C9-3]
DR ProteomicsDB; 62163; -. [Q4G1C9-4]
DR ProteomicsDB; 62164; -. [Q4G1C9-5]
DR ProteomicsDB; 62165; -. [Q4G1C9-6]
DR TopDownProteomics; Q4G1C9-6; -. [Q4G1C9-6]
DR Antibodypedia; 29602; 102 antibodies from 21 providers.
DR DNASU; 144321; -.
DR Ensembl; ENST00000320460.8; ENSP00000317385.4; ENSG00000180481.11. [Q4G1C9-2]
DR Ensembl; ENST00000378692.7; ENSP00000367963.3; ENSG00000180481.11. [Q4G1C9-5]
DR Ensembl; ENST00000547164.1; ENSP00000447980.1; ENSG00000180481.11. [Q4G1C9-4]
DR Ensembl; ENST00000550916.6; ENSP00000448248.1; ENSG00000180481.11. [Q4G1C9-1]
DR GeneID; 144321; -.
DR KEGG; hsa:144321; -.
DR MANE-Select; ENST00000550916.6; ENSP00000448248.1; NM_001270396.2; NP_001257325.1.
DR UCSC; uc001sxp.3; human. [Q4G1C9-1]
DR CTD; 144321; -.
DR GeneCards; GLIPR1L2; -.
DR HGNC; HGNC:28592; GLIPR1L2.
DR HPA; ENSG00000180481; Tissue enriched (testis).
DR MIM; 610394; gene.
DR neXtProt; NX_Q4G1C9; -.
DR OpenTargets; ENSG00000180481; -.
DR PharmGKB; PA145008279; -.
DR VEuPathDB; HostDB:ENSG00000180481; -.
DR eggNOG; KOG3017; Eukaryota.
DR GeneTree; ENSGT00940000162357; -.
DR HOGENOM; CLU_035730_2_0_1; -.
DR InParanoid; Q4G1C9; -.
DR OMA; YYQFWYP; -.
DR OrthoDB; 1528782at2759; -.
DR PhylomeDB; Q4G1C9; -.
DR TreeFam; TF316148; -.
DR PathwayCommons; Q4G1C9; -.
DR SignaLink; Q4G1C9; -.
DR BioGRID-ORCS; 144321; 19 hits in 1074 CRISPR screens.
DR ChiTaRS; GLIPR1L2; human.
DR GenomeRNAi; 144321; -.
DR Pharos; Q4G1C9; Tdark.
DR PRO; PR:Q4G1C9; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q4G1C9; protein.
DR Bgee; ENSG00000180481; Expressed in left testis and 95 other tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0007339; P:binding of sperm to zona pellucida; IBA:GO_Central.
DR CDD; cd05385; CAP_GLIPR1-like; 1.
DR Gene3D; 3.40.33.10; -; 1.
DR InterPro; IPR014044; CAP_domain.
DR InterPro; IPR035940; CAP_sf.
DR InterPro; IPR001283; CRISP-related.
DR InterPro; IPR034121; SCP_GLIPR-1-like.
DR PANTHER; PTHR10334; PTHR10334; 1.
DR Pfam; PF00188; CAP; 1.
DR PRINTS; PR00837; V5TPXLIKE.
DR SMART; SM00198; SCP; 1.
DR SUPFAM; SSF55797; SSF55797; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..344
FT /note="GLIPR1-like protein 2"
FT /id="PRO_0000324387"
FT TRANSMEM 254..274
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 58..192
FT /note="SCP"
FT REGION 292..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 315..344
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..107
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000305"
FT /id="VSP_032239"
FT VAR_SEQ 1..77
FT /note="Missing (in isoform 6)"
FT /evidence="ECO:0000305"
FT /id="VSP_032240"
FT VAR_SEQ 78
FT /note="M -> MLITMILHRARTK (in isoform 6)"
FT /evidence="ECO:0000305"
FT /id="VSP_032241"
FT VAR_SEQ 79..106
FT /note="TWDVALSRTARAWGKKCLFTHNIYLQDV -> LWYCCDSDGSRFIIGFPNLS
FT PRTPSAPL (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_032242"
FT VAR_SEQ 107..344
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_032243"
FT VAR_SEQ 161
FT /note="L -> RNTDEKTL (in isoform 4)"
FT /evidence="ECO:0000305"
FT /id="VSP_032244"
FT VAR_SEQ 162..344
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000305"
FT /id="VSP_032245"
FT VAR_SEQ 225..344
FT /note="NADRDQATYYRFWYPKWEMPRPVVCDPLCTFILLLRILCFILCVITVLIVQS
FT QFPNILLEQQMIFTPEESEAGNEEEEKEEEKKEKEEMEMEIMEMEEEKEEREEEEEETQ
FT KEKMEEEEK -> KIKKINMKKMHNGLDKKNKRLNTSFLWSC (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_032246"
SQ SEQUENCE 344 AA; 40179 MW; 8D19B8CB2CEC5786 CRC64;
MEAARPFARE WRAQSLPLAV GGVLKLRLCE LWLLLLGSSL NARFLPDEED VDFINEYVNL
HNELRGDVIP RGSNLRFMTW DVALSRTARA WGKKCLFTHN IYLQDVQMVH PKFYGIGENM
WVGPENEFTA SIAIRSWHAE KKMYNFENGS CSGDCSNYIQ LVWDHSYKVG CAVTPCSKIG
HIIHAAIFIC NYAPGGTLTR RPYEPGIFCT RCGRRDKCTD FLCSNADRDQ ATYYRFWYPK
WEMPRPVVCD PLCTFILLLR ILCFILCVIT VLIVQSQFPN ILLEQQMIFT PEESEAGNEE
EEKEEEKKEK EEMEMEIMEM EEEKEEREEE EEETQKEKME EEEK
