GRPL2_MOUSE
ID GRPL2_MOUSE Reviewed; 332 AA.
AC Q9CQ35; Q148R1; Q3TTM5;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=GLIPR1-like protein 2;
GN Name=Glipr1l2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9CQ35-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9CQ35-2; Sequence=VSP_032247, VSP_032248;
CC -!- SIMILARITY: Belongs to the CRISP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAE36300.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK014846; BAB29580.1; -; mRNA.
DR EMBL; AK015834; BAB29994.1; -; mRNA.
DR EMBL; AK161292; BAE36300.1; ALT_SEQ; mRNA.
DR EMBL; BC118017; AAI18018.1; -; mRNA.
DR CCDS; CCDS24171.1; -. [Q9CQ35-1]
DR CCDS; CCDS83755.1; -. [Q9CQ35-2]
DR RefSeq; NP_001334086.1; NM_001347157.1. [Q9CQ35-2]
DR RefSeq; NP_080499.1; NM_026223.2. [Q9CQ35-1]
DR AlphaFoldDB; Q9CQ35; -.
DR SMR; Q9CQ35; -.
DR STRING; 10090.ENSMUSP00000020434; -.
DR GlyGen; Q9CQ35; 1 site.
DR iPTMnet; Q9CQ35; -.
DR PhosphoSitePlus; Q9CQ35; -.
DR PaxDb; Q9CQ35; -.
DR PRIDE; Q9CQ35; -.
DR ProteomicsDB; 271439; -. [Q9CQ35-1]
DR ProteomicsDB; 271440; -. [Q9CQ35-2]
DR Antibodypedia; 29602; 102 antibodies from 21 providers.
DR DNASU; 67537; -.
DR Ensembl; ENSMUST00000020434; ENSMUSP00000020434; ENSMUSG00000020214. [Q9CQ35-1]
DR Ensembl; ENSMUST00000148897; ENSMUSP00000122771; ENSMUSG00000020214. [Q9CQ35-2]
DR GeneID; 67537; -.
DR KEGG; mmu:67537; -.
DR UCSC; uc007hal.1; mouse. [Q9CQ35-1]
DR UCSC; uc011xnh.1; mouse. [Q9CQ35-2]
DR CTD; 144321; -.
DR MGI; MGI:1914787; Glipr1l2.
DR VEuPathDB; HostDB:ENSMUSG00000020214; -.
DR eggNOG; KOG3017; Eukaryota.
DR GeneTree; ENSGT00940000162357; -.
DR HOGENOM; CLU_035730_2_0_1; -.
DR InParanoid; Q9CQ35; -.
DR OMA; YYQFWYP; -.
DR OrthoDB; 1528782at2759; -.
DR PhylomeDB; Q9CQ35; -.
DR TreeFam; TF316148; -.
DR BioGRID-ORCS; 67537; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Glipr1l2; mouse.
DR PRO; PR:Q9CQ35; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q9CQ35; protein.
DR Bgee; ENSMUSG00000020214; Expressed in spermatocyte and 6 other tissues.
DR Genevisible; Q9CQ35; MM.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0007339; P:binding of sperm to zona pellucida; IBA:GO_Central.
DR Gene3D; 3.40.33.10; -; 1.
DR InterPro; IPR014044; CAP_domain.
DR InterPro; IPR035940; CAP_sf.
DR InterPro; IPR001283; CRISP-related.
DR InterPro; IPR002413; V5_allergen-like.
DR PANTHER; PTHR10334; PTHR10334; 1.
DR Pfam; PF00188; CAP; 1.
DR PRINTS; PR00838; V5ALLERGEN.
DR PRINTS; PR00837; V5TPXLIKE.
DR SMART; SM00198; SCP; 1.
DR SUPFAM; SSF55797; SSF55797; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Glycoprotein; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..332
FT /note="GLIPR1-like protein 2"
FT /id="PRO_0000324388"
FT TRANSMEM 253..273
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 57..191
FT /note="SCP"
FT REGION 293..332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..332
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 145
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 224..226
FT /note="NTV -> KTK (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_032247"
FT VAR_SEQ 227..332
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_032248"
SQ SEQUENCE 332 AA; 37784 MW; CEDDBA2A0697FDDC CRC64;
MKASLPWSVV WRAQSNYVRL RRVLKLCELW LLLVGSGLNA KLPLEEDVDF INEYVGLHNE
LRGTVFPPGV NLRFMTWDVA LSRTARAWGK KCMYSRNTHL DKLHESHPVF TEIGENMWVG
PVEDFTVTTA IRSWHEERKS YSYLNDTCVE DQNCSHYIQL VWDSSYKVGC AVTSCARAGG
FTHAALFICN YAPGGTLTRR PYQAGQFCSR CGPGDQCTDY LCSNTVRDEA TYYQFWYPPW
EKPRPVVCNP MCIFILFLRV ASLLLCVIVV LIVQSRFPVI LMETPTIISA EEEGKTEVEI
VMEEGEGEGE GGEGEGEGEE KEEEEMLEED EQ
