ID   GRP_ALLMI               Reviewed;          28 AA.
AC   P31886;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Gastrin-releasing peptide;
DE            Short=GRP;
DE   Contains:
DE     RecName: Full=Neuromedin-C;
DE     AltName: Full=GRP-10;
GN   Name=GRP;
OS   Alligator mississippiensis (American alligator).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC   Alligator.
OX   NCBI_TaxID=8496;
RN   [1]
RP   PROTEIN SEQUENCE, AND AMIDATION AT MET-28.
RC   TISSUE=Stomach;
RX   PubMed=8101369; DOI=10.1016/0196-9781(93)90147-9;
RA   Wang Y., Conlon J.M.;
RT   "Neuroendocrine peptides (NPY, GRP, VIP, somatostatin) from the brain and
RT   stomach of the alligator.";
RL   Peptides 14:573-579(1993).
CC   -!- FUNCTION: Stimulates the release of gastrin and other gastrointestinal
CC       hormones. {ECO:0000250|UniProtKB:P63153}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P07492}.
CC       Cytoplasmic vesicle, secretory vesicle lumen
CC       {ECO:0000250|UniProtKB:Q863C3}.
CC   -!- SIMILARITY: Belongs to the bombesin/neuromedin-B/ranatensin family.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; P31886; -.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0034774; C:secretory granule lumen; ISS:UniProtKB.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:InterPro.
DR   GO; GO:0090277; P:positive regulation of peptide hormone secretion; ISS:UniProtKB.
DR   GO; GO:1900738; P:positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR   InterPro; IPR000874; Bombesin.
DR   Pfam; PF02044; Bombesin; 1.
DR   PROSITE; PS00257; BOMBESIN; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cytoplasmic vesicle; Direct protein sequencing; Secreted.
FT   PEPTIDE         1..28
FT                   /note="Gastrin-releasing peptide"
FT                   /evidence="ECO:0000269|PubMed:8101369"
FT                   /id="PRO_0000045916"
FT   PEPTIDE         19..28
FT                   /note="Neuromedin-C"
FT                   /evidence="ECO:0000269|PubMed:8101369"
FT                   /id="PRO_0000003046"
FT   MOD_RES         28
FT                   /note="Methionine amide"
FT                   /evidence="ECO:0000269|PubMed:8101369"
SQ   SEQUENCE   28 AA;  2786 MW;  A74DB0487D844963 CRC64;
     APAPSGGGSA PLAKIYPRGS HWAVGHLM