GRP_CHICK
ID GRP_CHICK Reviewed; 164 AA.
AC P01295; A0A3Q2U7K9;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 25-MAY-2022, sequence version 2.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Gastrin-releasing peptide;
DE Short=GRP;
DE AltName: Full=Proventricular peptide;
DE Contains:
DE RecName: Full=Neuromedin-C;
DE AltName: Full=GRP-10;
DE Flags: Precursor;
GN Name=GRP;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1] {ECO:0000312|Proteomes:UP000000539}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Red jungle fowl {ECO:0000312|Proteomes:UP000000539};
RX PubMed=15592404; DOI=10.1038/nature03154;
RA Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P.,
RA Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B.,
RA Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C.,
RA Fulton R.S., Graves T.A., Kremitzki C., Layman D., Magrini V.,
RA McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O.,
RA Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W.,
RA Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D.,
RA Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K.,
RA Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L.,
RA Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B.,
RA Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M.,
RA Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K.,
RA Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E.,
RA Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M.,
RA Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M.,
RA Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S.,
RA Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M.,
RA Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M.,
RA Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A.,
RA Elnitski L., Eswara P., King D.C., Yang S.-P., Tyekucheva S.,
RA Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J.,
RA Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J.,
RA Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E.,
RA Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M.,
RA Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A.,
RA Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M.,
RA Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O.,
RA Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E.,
RA Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S.,
RA Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E.,
RA Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R.,
RA Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R.,
RA Wilson R.K.;
RT "Sequence and comparative analysis of the chicken genome provide unique
RT perspectives on vertebrate evolution.";
RL Nature 432:695-716(2004).
RN [2]
RP PROTEIN SEQUENCE OF 28-54.
RX PubMed=7215543; DOI=10.1016/0014-5793(80)80398-x;
RA McDonald T.J., Joernvall H., Ghatei M., Bloom S.R., Mutt V.;
RT "Characterization of an avian gastric (proventricular) peptide having
RT sequence homology with the porcine gastrin-releasing peptide and the
RT amphibian peptides bombesin and alytesin.";
RL FEBS Lett. 122:45-48(1980).
RN [3]
RP PROTEIN SEQUENCE OF 28-54, AMIDATION AT MET-54, AND FUNCTION.
RX PubMed=2297533; DOI=10.1016/0167-4781(90)90023-u;
RA Campbell B.J., Young J., Dimaline R., Dockray G.J.;
RT "Isolation, sequence and biosynthetic significance of a novel fragment of
RT gastrin-releasing peptide from chicken proventriculus.";
RL Biochim. Biophys. Acta 1048:66-71(1990).
CC -!- FUNCTION: Stimulates the release of gastrin and other gastrointestinal
CC hormones (By similarity). Stimulates pancreatic protein and fluid
CC secretion, and increases acid secretion from the avian proventriculus
CC (PubMed:2297533). {ECO:0000250|UniProtKB:P63153,
CC ECO:0000269|PubMed:2297533}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P07492}.
CC Cytoplasmic vesicle, secretory vesicle lumen
CC {ECO:0000250|UniProtKB:Q863C3}.
CC -!- SIMILARITY: Belongs to the bombesin/neuromedin-B/ranatensin family.
CC {ECO:0000305}.
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DR EMBL; AC191339; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PIR; A01563; RHCHA.
DR AlphaFoldDB; P01295; -.
DR STRING; 9031.ENSGALP00000041621; -.
DR PaxDb; P01295; -.
DR Ensembl; ENSGALT00000103684; ENSGALP00000070188; ENSGALG00000040959.
DR VEuPathDB; HostDB:geneid_425213; -.
DR eggNOG; ENOG502S4DG; Eukaryota.
DR GeneTree; ENSGT00940000154470; -.
DR HOGENOM; CLU_144892_0_0_1; -.
DR InParanoid; P01295; -.
DR Reactome; R-GGA-375276; Peptide ligand-binding receptors.
DR Reactome; R-GGA-381771; Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).
DR Reactome; R-GGA-416476; G alpha (q) signalling events.
DR Proteomes; UP000000539; Chromosome Z.
DR Bgee; ENSGALG00000040959; Expressed in spermatocyte and 8 other tissues.
DR GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR GO; GO:0034774; C:secretory granule lumen; ISS:UniProtKB.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:InterPro.
DR GO; GO:0090277; P:positive regulation of peptide hormone secretion; ISS:UniProtKB.
DR GO; GO:1900738; P:positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR InterPro; IPR000874; Bombesin.
DR InterPro; IPR015674; Gastrin-RP.
DR PANTHER; PTHR16866; PTHR16866; 1.
DR PANTHER; PTHR16866:SF2; PTHR16866:SF2; 1.
DR Pfam; PF02044; Bombesin; 1.
DR PROSITE; PS00257; BOMBESIN; 1.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; Cytoplasmic vesicle;
KW Direct protein sequencing; Reference proteome; Secreted; Signal.
FT SIGNAL 1..27
FT /evidence="ECO:0000269|PubMed:2297533,
FT ECO:0000269|PubMed:7215543"
FT PEPTIDE 28..54
FT /note="Gastrin-releasing peptide"
FT /evidence="ECO:0000269|PubMed:2297533,
FT ECO:0000269|PubMed:7215543"
FT /id="PRO_0000223263"
FT PEPTIDE 45..54
FT /note="Neuromedin-C"
FT /evidence="ECO:0000269|PubMed:2297533"
FT /id="PRO_0000003045"
FT PROPEP 58..164
FT /evidence="ECO:0000269|PubMed:2297533,
FT ECO:0000269|PubMed:7215543"
FT /id="PRO_0000455541"
FT MOD_RES 54
FT /note="Methionine amide"
FT /evidence="ECO:0000269|PubMed:2297533"
SQ SEQUENCE 164 AA; 17807 MW; BE0365CB506B481A CRC64;
MGGGGPRRPG TLPLLALLAL LAAHGGAAPL QPGGSPALTK IYPRGSHWAV GHLMGKKSTG
DFPYAYEEEN KIPLSASPEN IKQLDDYLQR EEMSKHLLQL LEGNENKSAH FSKGGLPWHT
RNSWETDDSS SWKDVSRTRC VSAFLTVTFC SKVAYQLCPT SALS
