ID   GRP_ONCMY               Reviewed;          23 AA.
AC   Q9PS30;
DT   11-FEB-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=Gastrin-releasing peptide;
DE            Short=GRP;
GN   Name=grp;
OS   Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8022;
RN   [1]
RP   PROTEIN SEQUENCE, AND AMIDATION AT MET-23.
RC   TISSUE=Stomach;
RX   PubMed=1480521; DOI=10.1016/0196-9781(92)90061-7;
RA   Jensen J., Conlon J.M.;
RT   "Isolation and primary structure of gastrin-releasing peptide from a
RT   teleost fish, the trout (Oncorhynchus mykiss).";
RL   Peptides 13:995-999(1992).
CC   -!- FUNCTION: Stimulates the release of gastrin and other gastrointestinal
CC       hormones. {ECO:0000250|UniProtKB:P63153}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P07492}.
CC       Cytoplasmic vesicle, secretory vesicle lumen
CC       {ECO:0000250|UniProtKB:Q863C3}.
CC   -!- SIMILARITY: Belongs to the bombesin/neuromedin-B/ranatensin family.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; Q9PS30; -.
DR   GO; GO:0044297; C:cell body; IDA:AgBase.
DR   GO; GO:0070852; C:cell body fiber; IDA:AgBase.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0034774; C:secretory granule lumen; ISS:UniProtKB.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:InterPro.
DR   GO; GO:0090277; P:positive regulation of peptide hormone secretion; ISS:UniProtKB.
DR   GO; GO:1900738; P:positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR   InterPro; IPR000874; Bombesin.
DR   Pfam; PF02044; Bombesin; 1.
DR   PROSITE; PS00257; BOMBESIN; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cytoplasmic vesicle; Direct protein sequencing; Secreted.
FT   PEPTIDE         1..23
FT                   /note="Gastrin-releasing peptide"
FT                   /evidence="ECO:0000269|PubMed:1480521"
FT                   /id="PRO_0000043497"
FT   MOD_RES         23
FT                   /note="Methionine amide"
FT                   /evidence="ECO:0000269|PubMed:1480521"
SQ   SEQUENCE   23 AA;  2479 MW;  94CD79F70E3DB637 CRC64;
     SENTGAIGKV FPRGNHWAVG HLM