ID   GRP_SCYCA               Reviewed;          25 AA.
AC   P09472;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Gastrin-releasing peptide;
DE            Short=GRP;
GN   Name=grp;
OS   Scyliorhinus canicula (Small-spotted catshark) (Squalus canicula).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Elasmobranchii; Galeomorphii; Galeoidea; Carcharhiniformes; Scyliorhinidae;
OC   Scyliorhinus.
OX   NCBI_TaxID=7830;
RN   [1]
RP   PROTEIN SEQUENCE, AND AMIDATION AT MET-25.
RX   PubMed=3436516; DOI=10.1016/0016-6480(87)90080-3;
RA   Conlon J.M., Henderson I.W., Thim L.;
RT   "Gastrin-releasing peptide from the intestine of the elasmobranch fish,
RT   Scyliorhinus canicula (common dogfish).";
RL   Gen. Comp. Endocrinol. 68:415-420(1987).
CC   -!- FUNCTION: Stimulates the release of gastrin and other gastrointestinal
CC       hormones. {ECO:0000250|UniProtKB:P63153}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P07492}.
CC       Cytoplasmic vesicle, secretory vesicle lumen
CC       {ECO:0000250|UniProtKB:Q863C3}.
CC   -!- SIMILARITY: Belongs to the bombesin/neuromedin-B/ranatensin family.
CC       {ECO:0000305}.
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DR   PIR; S06263; S06263.
DR   AlphaFoldDB; P09472; -.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0034774; C:secretory granule lumen; ISS:UniProtKB.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:InterPro.
DR   GO; GO:0090277; P:positive regulation of peptide hormone secretion; ISS:UniProtKB.
DR   GO; GO:1900738; P:positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR   InterPro; IPR000874; Bombesin.
DR   Pfam; PF02044; Bombesin; 1.
DR   PROSITE; PS00257; BOMBESIN; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cytoplasmic vesicle; Direct protein sequencing; Secreted.
FT   PEPTIDE         1..25
FT                   /note="Gastrin-releasing peptide"
FT                   /evidence="ECO:0000269|PubMed:3436516"
FT                   /id="PRO_0000043498"
FT   MOD_RES         25
FT                   /note="Methionine amide"
FT                   /evidence="ECO:0000269|PubMed:3436516"
SQ   SEQUENCE   25 AA;  2781 MW;  B735F911B89007F8 CRC64;
     APVENQGSFP KMFPRGSHWA VGHLM