GRP_ZYMMA
ID GRP_ZYMMA Reviewed; 164 AA.
AC F8DT92; P74996; Q5NQC4;
DT 14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT 21-SEP-2011, sequence version 1.
DT 03-AUG-2022, entry version 58.
DE RecName: Full=Glutamate uptake regulatory protein;
GN Name=grp; OrderedLocusNames=Zmob_0988;
OS Zymomonas mobilis subsp. mobilis (strain ATCC 10988 / DSM 424 / LMG 404 /
OS NCIMB 8938 / NRRL B-806 / ZM1).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Sphingomonadales;
OC Zymomonadaceae; Zymomonas.
OX NCBI_TaxID=555217;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC STRAIN=ATCC 10988 / DSM 424 / CCUG 17860 / LMG 404 / NCIMB 8938 / NRRL
RC B-806 / ZM1;
RX PubMed=7665494; DOI=10.1128/jb.177.17.5140-5147.1995;
RA Peekhaus N., Tolner B., Poolman B., Kramer R.;
RT "The glutamate uptake regulatory protein (Grp) of Zymomonas mobilis and its
RT relation to the global regulator Lrp of Escherichia coli.";
RL J. Bacteriol. 177:5140-5147(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10988 / DSM 424 / CCUG 17860 / LMG 404 / NCIMB 8938 / NRRL
RC B-806 / ZM1;
RX PubMed=21725006; DOI=10.1128/jb.05395-11;
RA Pappas K.M., Kouvelis V.N., Saunders E., Brettin T.S., Bruce D., Detter C.,
RA Balakireva M., Han C.S., Savvakis G., Kyrpides N.C., Typas M.A.;
RT "Genome sequence of the ethanol-producing Zymomonas mobilis subsp. mobilis
RT lectotype strain ATCC 10988.";
RL J. Bacteriol. 193:5051-5052(2011).
CC -!- FUNCTION: Represses the secondary, H(+)-coupled glutamate uptake system
CC (Gluemp) genes. {ECO:0000269|PubMed:7665494}.
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DR EMBL; X84019; CAA58841.1; -; Genomic_DNA.
DR EMBL; CP002850; AEH62823.1; -; Genomic_DNA.
DR PIR; S52279; S52279.
DR AlphaFoldDB; F8DT92; -.
DR SMR; F8DT92; -.
DR STRING; 555217.Zmob_0988; -.
DR EnsemblBacteria; AEH62823; AEH62823; Zmob_0988.
DR KEGG; zmm:Zmob_0988; -.
DR eggNOG; COG1522; Bacteria.
DR HOGENOM; CLU_091233_0_2_5; -.
DR OMA; VEFHRMA; -.
DR Proteomes; UP000001494; Chromosome.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProt.
DR CDD; cd00090; HTH_ARSR; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR011991; ArsR-like_HTH.
DR InterPro; IPR000485; AsnC-type_HTH_dom.
DR InterPro; IPR011008; Dimeric_a/b-barrel.
DR InterPro; IPR019888; Tscrpt_reg_AsnC-like.
DR InterPro; IPR019887; Tscrpt_reg_AsnC/Lrp_C.
DR InterPro; IPR019885; Tscrpt_reg_HTH_AsnC-type_CS.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF01037; AsnC_trans_reg; 1.
DR PRINTS; PR00033; HTHASNC.
DR SMART; SM00344; HTH_ASNC; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF54909; SSF54909; 1.
DR PROSITE; PS00519; HTH_ASNC_1; 1.
DR PROSITE; PS50956; HTH_ASNC_2; 1.
PE 4: Predicted;
KW DNA-binding; Repressor; Transcription; Transcription regulation.
FT CHAIN 1..164
FT /note="Glutamate uptake regulatory protein"
FT /id="PRO_0000414235"
FT DOMAIN 5..66
FT /note="HTH asnC-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00319"
FT DNA_BIND 24..43
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00319"
FT CONFLICT 14
FT /note="D -> V (in Ref. 1; CAA58841)"
FT /evidence="ECO:0000305"
FT CONFLICT 18
FT /note="H -> D (in Ref. 1; CAA58841)"
FT /evidence="ECO:0000305"
FT CONFLICT 74..80
FT /note="RCAEHSQ -> TVRNIPN (in Ref. 1; CAA58841)"
FT /evidence="ECO:0000305"
FT CONFLICT 121
FT /note="D -> H (in Ref. 1; CAA58841)"
FT /evidence="ECO:0000305"
FT CONFLICT 164
FT /note="V -> A (in Ref. 1; CAA58841)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 164 AA; 18751 MW; 2404FE33D4E7F17C CRC64;
MIRKLDDFDI KILDLLQHDA TATMAELSEK TGLSANACWR RIRLLEADGV IKNRVTLLDP
QKIGLGITVF VCIRCAEHSQ DWLDNFLQIV NESPEVIEFY RLAGDIDYLL KLQVASISEY
DRLYKKLVSR VKLTDVSAIF SMEELKHSTI LPLPETSDKA ERKV
