ID   GRT1A_DANRE             Reviewed;         356 AA.
AC   Q6PBU5;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Growth hormone-regulated TBC protein 1-A;
GN   Name=grtp1a; Synonyms=grtp1;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Retina;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act as a GTPase-activating protein for Rab family
CC       protein(s).
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DR   EMBL; BC059581; AAH59581.1; -; mRNA.
DR   RefSeq; NP_998567.1; NM_213402.1.
DR   AlphaFoldDB; Q6PBU5; -.
DR   SMR; Q6PBU5; -.
DR   STRING; 7955.ENSDARP00000045883; -.
DR   PaxDb; Q6PBU5; -.
DR   PRIDE; Q6PBU5; -.
DR   GeneID; 406711; -.
DR   KEGG; dre:406711; -.
DR   CTD; 406711; -.
DR   ZFIN; ZDB-GENE-040426-2733; grtp1a.
DR   eggNOG; KOG2058; Eukaryota.
DR   InParanoid; Q6PBU5; -.
DR   OrthoDB; 1162786at2759; -.
DR   PhylomeDB; Q6PBU5; -.
DR   PRO; PR:Q6PBU5; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR   GO; GO:0090630; P:activation of GTPase activity; IBA:GO_Central.
DR   InterPro; IPR000195; Rab-GTPase-TBC_dom.
DR   InterPro; IPR035969; Rab-GTPase_TBC_sf.
DR   Pfam; PF00566; RabGAP-TBC; 1.
DR   SMART; SM00164; TBC; 1.
DR   SUPFAM; SSF47923; SSF47923; 2.
DR   PROSITE; PS50086; TBC_RABGAP; 1.
PE   2: Evidence at transcript level;
KW   GTPase activation; Reference proteome.
FT   CHAIN           1..356
FT                   /note="Growth hormone-regulated TBC protein 1-A"
FT                   /id="PRO_0000288711"
FT   DOMAIN          87..277
FT                   /note="Rab-GAP TBC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00163"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        12..26
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   356 AA;  41623 MW;  3226AF2EFCBAF081 CRC64;
     MEERDRTGRT GQPQHRINQP STARERANSV DAYGFQRSDD FDYETHEQLM SEYLAVLTRR
     SIRWAKLLQG RRRVDRNLKV KRYVRKGVPN EHRPLVWMVC SGAQEQMDRN PGYYQSLLDT
     HHEPKLEESI RTDLHRTFPD NIYFRKSAEP CLQQALYNVL VAYGHHNKAV GYCQGMNFIA
     GYLILVSKDE ETSFWLMEAL LSRILPDYYT PAMLGLKTDQ EVLGELVRLK APAVWKLMQD
     QGVMWTLVVS RWFICLFIDV LPVETVLRIW DCLFYEGSKI LFRVALTLIR HHQQEIAEAQ
     NLPDVCERFK RITRGAFVED CHTFMQKIFQ EPGSLSMATV SKLRESCRAR IIADES