GRTP1_MOUSE
ID GRTP1_MOUSE Reviewed; 359 AA.
AC Q9D3N8; Q8BUR0; Q8VI03; Q9D3Q5; Q9D8L8;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Growth hormone-regulated TBC protein 1;
DE AltName: Full=TBC1 domain family member 6;
GN Name=Grtp1; Synonyms=Tbc1d6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RX PubMed=11564724; DOI=10.1210/endo.142.10.8527;
RA Lu C., Kasik J., Stephan D.A., Yang S., Sperling M.A., Menon R.K.;
RT "Grtp1, a novel gene regulated by growth hormone.";
RL Endocrinology 142:4568-4571(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4).
RC STRAIN=C57BL/6J;
RC TISSUE=Embryonic stem cell, Head, Ovary, Pancreas, Retina, and Uterus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May act as a GTPase-activating protein for Rab family
CC protein(s).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q9D3N8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9D3N8-2; Sequence=VSP_025757;
CC Name=3;
CC IsoId=Q9D3N8-3; Sequence=VSP_025756, VSP_025757;
CC Name=4;
CC IsoId=Q9D3N8-4; Sequence=VSP_025757, VSP_025758;
CC -!- TISSUE SPECIFICITY: Highly expressed in testes, expression greatly
CC increased at postnatal day 20 and remained high up to day 90.
CC Moderately expressed in kidney and liver, weakly expressed in
CC intestine, lung, ovaries and stomach. Expression of Growth hormone
CC increased the expression in testis but decreased expression in liver
CC and kidney. {ECO:0000269|PubMed:11564724}.
CC -!- DEVELOPMENTAL STAGE: Weakly expressed in the testis of the embryo and
CC neonate. {ECO:0000269|PubMed:11564724}.
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DR EMBL; AF329833; AAL67673.1; -; mRNA.
DR EMBL; AK007905; BAB25339.1; -; mRNA.
DR EMBL; AK017197; BAB30630.1; -; mRNA.
DR EMBL; AK017251; BAB30653.1; -; mRNA.
DR EMBL; AK082863; BAC38658.1; -; mRNA.
DR EMBL; AK149322; BAE28813.1; -; mRNA.
DR EMBL; BC029096; AAH29096.1; -; mRNA.
DR CCDS; CCDS22107.1; -. [Q9D3N8-2]
DR CCDS; CCDS90375.1; -. [Q9D3N8-1]
DR RefSeq; NP_080044.2; NM_025768.2. [Q9D3N8-2]
DR RefSeq; XP_006508914.1; XM_006508851.3. [Q9D3N8-4]
DR RefSeq; XP_017168426.1; XM_017312937.1. [Q9D3N8-3]
DR AlphaFoldDB; Q9D3N8; -.
DR SMR; Q9D3N8; -.
DR IntAct; Q9D3N8; 1.
DR STRING; 10090.ENSMUSP00000130324; -.
DR iPTMnet; Q9D3N8; -.
DR PhosphoSitePlus; Q9D3N8; -.
DR MaxQB; Q9D3N8; -.
DR PaxDb; Q9D3N8; -.
DR PeptideAtlas; Q9D3N8; -.
DR PRIDE; Q9D3N8; -.
DR ProteomicsDB; 271461; -. [Q9D3N8-1]
DR ProteomicsDB; 271462; -. [Q9D3N8-2]
DR ProteomicsDB; 271463; -. [Q9D3N8-3]
DR ProteomicsDB; 271464; -. [Q9D3N8-4]
DR Antibodypedia; 25922; 125 antibodies from 25 providers.
DR DNASU; 66790; -.
DR Ensembl; ENSMUST00000165605; ENSMUSP00000130324; ENSMUSG00000038515. [Q9D3N8-1]
DR Ensembl; ENSMUST00000210317; ENSMUSP00000148042; ENSMUSG00000038515. [Q9D3N8-2]
DR Ensembl; ENSMUST00000211128; ENSMUSP00000147337; ENSMUSG00000038515. [Q9D3N8-4]
DR GeneID; 66790; -.
DR KEGG; mmu:66790; -.
DR UCSC; uc009kxc.1; mouse. [Q9D3N8-3]
DR UCSC; uc009kxd.1; mouse. [Q9D3N8-2]
DR UCSC; uc012fzv.1; mouse. [Q9D3N8-1]
DR CTD; 79774; -.
DR MGI; MGI:1914040; Grtp1.
DR VEuPathDB; HostDB:ENSMUSG00000038515; -.
DR eggNOG; KOG2058; Eukaryota.
DR GeneTree; ENSGT00940000154927; -.
DR HOGENOM; CLU_005350_1_0_1; -.
DR InParanoid; Q9D3N8; -.
DR OMA; DTMIQDS; -.
DR OrthoDB; 1162786at2759; -.
DR PhylomeDB; Q9D3N8; -.
DR TreeFam; TF105771; -.
DR BioGRID-ORCS; 66790; 0 hits in 39 CRISPR screens.
DR ChiTaRS; Grtp1; mouse.
DR PRO; PR:Q9D3N8; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q9D3N8; protein.
DR Bgee; ENSMUSG00000038515; Expressed in spermatocyte and 202 other tissues.
DR ExpressionAtlas; Q9D3N8; baseline and differential.
DR Genevisible; Q9D3N8; MM.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0090630; P:activation of GTPase activity; IBA:GO_Central.
DR InterPro; IPR000195; Rab-GTPase-TBC_dom.
DR InterPro; IPR035969; Rab-GTPase_TBC_sf.
DR Pfam; PF00566; RabGAP-TBC; 2.
DR SMART; SM00164; TBC; 1.
DR SUPFAM; SSF47923; SSF47923; 2.
DR PROSITE; PS50086; TBC_RABGAP; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; GTPase activation; Reference proteome.
FT CHAIN 1..359
FT /note="Growth hormone-regulated TBC protein 1"
FT /id="PRO_0000288709"
FT DOMAIN 74..281
FT /note="Rab-GAP TBC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00163"
FT VAR_SEQ 1..84
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:11564724,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_025756"
FT VAR_SEQ 162..178
FT /note="Missing (in isoform 2, isoform 3 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:11564724,
FT ECO:0000303|PubMed:15489334, ECO:0000303|PubMed:16141072"
FT /id="VSP_025757"
FT VAR_SEQ 331..359
FT /note="KIFSEPGSLSMTTITRLRKSCRAALQAQS -> AATTSLLP (in
FT isoform 4)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_025758"
FT CONFLICT 216
FT /note="A -> P (in Ref. 2; BAB30630)"
FT /evidence="ECO:0000305"
FT CONFLICT 273
FT /note="I -> T (in Ref. 1; AAL67673)"
FT /evidence="ECO:0000305"
FT CONFLICT 324
FT /note="E -> G (in Ref. 1; AAL67673)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 359 AA; 40628 MW; 1D5FD2C296B38B18 CRC64;
MDPAERAQAA RARVPRIDPY GFERPEDFDY AAYEEFFSTY LVILTKRAIK WSKLLKGNGG
VRKSVTVKRY VRKGIPLEHR ARVWMAVSGA QARMDQSPGY YHRLLEGESS SSLDEAIRTD
LNRTFPDNVM FRKTADPCLQ KTLYNVLLAY GLHNPDVGYC QCCAQKPGSS AGLRSSLTGM
NFIAGYLILI TKNEEESFWL LDALVGRILP DYYSPAMLGL KTDQEVLAEL VRMKLPAVAA
LMDGHGVLWT LLVSRWFICL FVDILPVETV LRIWDCLFNE GSKIIFRVAL TLIKQHQEFI
LEASSIPDIC DKFKQITKGD FVTECHAFMQ KIFSEPGSLS MTTITRLRKS CRAALQAQS
