ID   GRTP1_RAT               Reviewed;         289 AA.
AC   Q4QQU7;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Growth hormone-regulated TBC protein 1;
GN   Name=Grtp1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May act as a GTPase-activating protein for Rab family
CC       protein(s).
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DR   EMBL; BC097985; AAH97985.1; -; mRNA.
DR   RefSeq; NP_001026983.1; NM_001031813.2.
DR   AlphaFoldDB; Q4QQU7; -.
DR   SMR; Q4QQU7; -.
DR   GeneID; 361180; -.
DR   KEGG; rno:361180; -.
DR   UCSC; RGD:1309210; rat.
DR   CTD; 79774; -.
DR   RGD; 1309210; Grtp1.
DR   VEuPathDB; HostDB:ENSRNOG00000019504; -.
DR   HOGENOM; CLU_005350_1_0_1; -.
DR   InParanoid; Q4QQU7; -.
DR   PRO; PR:Q4QQU7; -.
DR   Proteomes; UP000002494; Chromosome 16.
DR   Bgee; ENSRNOG00000061995; Expressed in adult mammalian kidney and 18 other tissues.
DR   ExpressionAtlas; Q4QQU7; baseline.
DR   Genevisible; Q4QQU7; RN.
DR   GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR   GO; GO:0090630; P:activation of GTPase activity; IBA:GO_Central.
DR   InterPro; IPR000195; Rab-GTPase-TBC_dom.
DR   InterPro; IPR035969; Rab-GTPase_TBC_sf.
DR   Pfam; PF00566; RabGAP-TBC; 1.
DR   SMART; SM00164; TBC; 1.
DR   SUPFAM; SSF47923; SSF47923; 2.
DR   PROSITE; PS50086; TBC_RABGAP; 1.
PE   2: Evidence at transcript level;
KW   GTPase activation; Reference proteome.
FT   CHAIN           1..289
FT                   /note="Growth hormone-regulated TBC protein 1"
FT                   /id="PRO_0000288710"
FT   DOMAIN          41..211
FT                   /note="Rab-GAP TBC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00163"
SQ   SEQUENCE   289 AA;  32929 MW;  443EEF24301CB523 CRC64;
     MDPAERAQAA RARVPRIDPY GFERPEDFDY AAYEEFFSTY LVILTKRAIK WSKLLKGSGG
     VRKSVTDLNR TFPDNVMFRK TADPCLQKTL YNVLLAYGLH NQDVGYCQGM NFIAGYLILI
     TKNEEESFWL LDALVGRILP DYYSPAMLGL KTDQEVLAEL VRMKLPAVAA LMDGHGVLWT
     LLVSRWFICL FVDILPVETV LRIWDCLFNE GSKIIFRVAL TLIKQHQEFI LEASSVPDIC
     DKFKQITKGD FVTECHTFMQ KIFSEPGSLS MATITRLRES CRAALQAQS