ID   GRTP1_XENTR             Reviewed;         342 AA.
AC   Q6GL87;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Growth hormone-regulated TBC protein 1;
GN   Name=grtp1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act as a GTPase-activating protein for Rab family
CC       protein(s).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC074617; AAH74617.1; -; mRNA.
DR   RefSeq; NP_001005632.1; NM_001005632.1.
DR   AlphaFoldDB; Q6GL87; -.
DR   SMR; Q6GL87; -.
DR   PaxDb; Q6GL87; -.
DR   DNASU; 448089; -.
DR   Ensembl; ENSXETT00000004220; ENSXETP00000004220; ENSXETG00000001972.
DR   GeneID; 448089; -.
DR   KEGG; xtr:448089; -.
DR   CTD; 79774; -.
DR   Xenbase; XB-GENE-950226; grtp1.
DR   eggNOG; KOG2058; Eukaryota.
DR   HOGENOM; CLU_005350_1_0_1; -.
DR   InParanoid; Q6GL87; -.
DR   OMA; YGFERRH; -.
DR   OrthoDB; 1162786at2759; -.
DR   PhylomeDB; Q6GL87; -.
DR   TreeFam; TF105771; -.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000001972; Expressed in mesonephros and 13 other tissues.
DR   ExpressionAtlas; Q6GL87; baseline.
DR   GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR   GO; GO:0090630; P:activation of GTPase activity; IBA:GO_Central.
DR   InterPro; IPR000195; Rab-GTPase-TBC_dom.
DR   InterPro; IPR035969; Rab-GTPase_TBC_sf.
DR   Pfam; PF00566; RabGAP-TBC; 1.
DR   SMART; SM00164; TBC; 1.
DR   SUPFAM; SSF47923; SSF47923; 2.
DR   PROSITE; PS50086; TBC_RABGAP; 1.
PE   2: Evidence at transcript level;
KW   GTPase activation; Reference proteome.
FT   CHAIN           1..342
FT                   /note="Growth hormone-regulated TBC protein 1"
FT                   /id="PRO_0000288713"
FT   DOMAIN          72..263
FT                   /note="Rab-GAP TBC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00163"
SQ   SEQUENCE   342 AA;  39602 MW;  C0AB6A93C63B816A CRC64;
     MDEANETAQD SVPRIDGYGF VRPAEFDYAF YEEFIARYHV VLTRRAIKWS KLLQQSAAVE
     KNMKVKRYIR KGIPNEHRSH VWMVVSGAQA QMDMNTGYFR RMFTEGEKNP KLLDLVITDL
     NRTFPDNVLF QKNANPSLQK DLYNVLVAYG QHNKTVGYCQ GMNFIAGYLI LVTKDEEKAF
     WLMDALIGQI LPDYYSPAMT GLKTDQEVLG DLVKKKIPSV AQLIETHGVM WTLLVSRWFI
     CLFIDILPVE TVLRIWDCLF FEGSKVIFRV ALTLIKQSQA SIMEARNFPD ICDKFKEITK
     GEFVTDCHYF MQKIFAEPGS LSKTTIDKLR EKQRLKLISE EK