ID   GRWD1_BOVIN             Reviewed;         446 AA.
AC   Q1JQD2;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2006, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Glutamate-rich WD repeat-containing protein 1;
GN   Name=GRWD1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Ascending colon;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Histone binding-protein that regulates chromatin dynamics and
CC       minichromosome maintenance (MCM) loading at replication origins,
CC       possibly by promoting chromatin openness.
CC       {ECO:0000250|UniProtKB:Q9BQ67}.
CC   -!- SUBUNIT: Interacts with METTL18. Interacts with CDT1; origin binding of
CC       GRWD1 is dependent on CDT1. Interacts with CDC6; origin binding of
CC       GRWD1 is dependent on CDC6. Binds to histone H2A-H2B and H3-H4
CC       complexes. {ECO:0000250|UniProtKB:Q9BQ67}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q9BQ67}. Nucleus {ECO:0000250|UniProtKB:Q9BQ67}.
CC       Chromosome {ECO:0000250|UniProtKB:Q9BQ67}. Note=Present in the nucleus
CC       throughout interphase and is detached from chromatin at the onset of
CC       mitosis and rebinds at telophase when the pre-replication complexes
CC       (pre-RC) is formed. {ECO:0000250|UniProtKB:Q9BQ67}.
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DR   EMBL; BC116037; AAI16038.1; -; mRNA.
DR   RefSeq; NP_001069707.1; NM_001076239.1.
DR   AlphaFoldDB; Q1JQD2; -.
DR   SMR; Q1JQD2; -.
DR   STRING; 9913.ENSBTAP00000000088; -.
DR   PaxDb; Q1JQD2; -.
DR   PRIDE; Q1JQD2; -.
DR   Ensembl; ENSBTAT00000000088; ENSBTAP00000000088; ENSBTAG00000000080.
DR   GeneID; 540739; -.
DR   KEGG; bta:540739; -.
DR   CTD; 83743; -.
DR   VEuPathDB; HostDB:ENSBTAG00000000080; -.
DR   VGNC; VGNC:29669; GRWD1.
DR   eggNOG; KOG0302; Eukaryota.
DR   GeneTree; ENSGT00550000075124; -.
DR   HOGENOM; CLU_025272_1_1_1; -.
DR   InParanoid; Q1JQD2; -.
DR   OMA; DWSPLQP; -.
DR   OrthoDB; 831322at2759; -.
DR   TreeFam; TF312982; -.
DR   Proteomes; UP000009136; Chromosome 18.
DR   Bgee; ENSBTAG00000000080; Expressed in conceptus and 106 other tissues.
DR   ExpressionAtlas; Q1JQD2; baseline and differential.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR   GO; GO:0003682; F:chromatin binding; ISS:UniProtKB.
DR   GO; GO:0003688; F:DNA replication origin binding; ISS:UniProtKB.
DR   GO; GO:0042393; F:histone binding; ISS:UniProtKB.
DR   GO; GO:0006260; P:DNA replication; ISS:UniProtKB.
DR   GO; GO:0006334; P:nucleosome assembly; ISS:UniProtKB.
DR   GO; GO:0006337; P:nucleosome disassembly; ISS:UniProtKB.
DR   GO; GO:0042254; P:ribosome biogenesis; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR022052; Histone-bd_RBBP4_N.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF12265; CAF1C_H4-bd; 1.
DR   Pfam; PF00400; WD40; 3.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Chromosome; Nucleus; Phosphoprotein; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..446
FT                   /note="Glutamate-rich WD repeat-containing protein 1"
FT                   /id="PRO_0000328717"
FT   REPEAT          212..252
FT                   /note="WD 1"
FT   REPEAT          259..299
FT                   /note="WD 2"
FT   REPEAT          306..345
FT                   /note="WD 3"
FT   REPEAT          351..391
FT                   /note="WD 4"
FT   REPEAT          412..445
FT                   /note="WD 5"
FT   REGION          1..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          110..141
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        121..137
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         10
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BQ67"
FT   MOD_RES         122
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BQ67"
FT   MOD_RES         344
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BQ67"
SQ   SEQUENCE   446 AA;  49463 MW;  2EDEE592CF598AFD CRC64;
     MAALKGRRRT CEPGESMETE SQETGSKGQA QVYLPGRGPP LREGEELVMD EEAYVLYHRA
     QTGAPCLSFD IVRDHLGDNR TELPLTLYLC AGTQAESSQS NRLMMLRMHN LHGTKPPPPE
     GSDDEEEEDD EEDEEERKPQ LELAMVPHYG GINRVRVSWL GEEPVAGVWS EKGQVEVFAL
     RRLLQVVDDP QALATFLRDE QTRMKPIFAF SGHMGEGFAL DWSPRVPGRL LTGDCQKNIH
     LWTPTDGGSW HVDQRPFVGH TRSVEDLQWS PTEDTVFASC SADASIRIWD IRAAPSKACM
     LTTATAHDGD VNVINWSHRE PFLLSGGDDG ALKVWDLRQF KSGSPVATFK QHVAPVTSVE
     WHPQDSGVFA ASGADNQITQ WDLAVERDPE AGDAETDPGL ADLPQQLLFV HQGETDLKEL
     HWHPQCPGVL VSTALSGFTV FRTISV