ID   GRWD1_DICDI             Reviewed;         482 AA.
AC   Q54ED4;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Glutamate-rich WD repeat-containing protein 1;
GN   Name=grwd1; ORFNames=DDB_G0291566;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
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DR   EMBL; AAFI02000177; EAL61767.1; -; Genomic_DNA.
DR   RefSeq; XP_635306.1; XM_630214.1.
DR   AlphaFoldDB; Q54ED4; -.
DR   SMR; Q54ED4; -.
DR   STRING; 44689.DDB0267050; -.
DR   PaxDb; Q54ED4; -.
DR   EnsemblProtists; EAL61767; EAL61767; DDB_G0291566.
DR   GeneID; 8628250; -.
DR   KEGG; ddi:DDB_G0291566; -.
DR   dictyBase; DDB_G0291566; grwd1.
DR   eggNOG; KOG0302; Eukaryota.
DR   HOGENOM; CLU_025272_2_1_1; -.
DR   InParanoid; Q54ED4; -.
DR   OMA; DWSPLQP; -.
DR   PhylomeDB; Q54ED4; -.
DR   PRO; PR:Q54ED4; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0042254; P:ribosome biogenesis; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR022052; Histone-bd_RBBP4_N.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF12265; CAF1C_H4-bd; 1.
DR   Pfam; PF00400; WD40; 3.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..482
FT                   /note="Glutamate-rich WD repeat-containing protein 1"
FT                   /id="PRO_0000328718"
FT   REPEAT          191..231
FT                   /note="WD 1"
FT   REPEAT          294..334
FT                   /note="WD 2"
FT   REPEAT          337..377
FT                   /note="WD 3"
FT   REPEAT          383..423
FT                   /note="WD 4"
FT   REPEAT          446..482
FT                   /note="WD 5"
FT   REGION          1..75
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          148..180
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        28..60
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        61..75
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        158..180
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   482 AA;  54567 MW;  07F10F6A0C90024B CRC64;
     MSSKKRSFGD IEFGESDEVG GTNVDVNGED DFENDDEVES FEDDEQSFEE IEEGGEEGGD
     NDGEDKGPKK VWRAGVDPLE EDEVLDYDST AYDMMHSMSV EWPCLSFHPI KDELGAQRNK
     YPHTMYLVAG TQADEAKNNK VIIMKAKQLH KTKHDDEDSD DDEDSDDDEE SDDEDDEDKD
     VDPELQLAFI NHNGAVNRIR SMDQQSNIVA TWSDNRSVYI WNIANHLKAL DNETVAPKQT
     APLHTISNHS IEGYALDWSP KIAGRLATGD CNNSIFVTNA SESTWKTDTQ AFKGHTESVE
     DIQWSPSEEK VFASCSIDQT VRIWDIRKPK PAITVKAHTA DVNVISWSRN VEYLLVSGCD
     DGSFRVWDLR AFKDNSPVSD FKYHTGPITS IEWNPYEESQ VIVSSSDDQV TIWDFSLEED
     TEEFTNANAN PDDDFQYPPQ LFFIHQGQHD IKEVHWHPQI PHVAISTSID GFNIFKSSNS
     EE