ID   GS1L2_HUMAN             Reviewed;         293 AA.
AC   A8MUP6; K7EL98;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2015, sequence version 3.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Germ cell-specific gene 1-like protein 2 {ECO:0000305};
DE            Short=GSG1-like protein 2 {ECO:0000305};
GN   Name=GSG1L2 {ECO:0000312|HGNC:HGNC:51826};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA   Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA   Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA   LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA   Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA   Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA   Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT   human lineage.";
RL   Nature 440:1045-1049(2006).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the GSG1 family. {ECO:0000305}.
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DR   EMBL; AC026591; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC027045; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS82072.1; -.
DR   RefSeq; NP_001297148.1; NM_001310219.1.
DR   AlphaFoldDB; A8MUP6; -.
DR   SMR; A8MUP6; -.
DR   GlyGen; A8MUP6; 2 sites.
DR   BioMuta; GSG1L2; -.
DR   PaxDb; A8MUP6; -.
DR   PeptideAtlas; A8MUP6; -.
DR   PRIDE; A8MUP6; -.
DR   Antibodypedia; 71262; 3 antibodies from 3 providers.
DR   DNASU; 644070; -.
DR   Ensembl; ENST00000399363.5; ENSP00000465978.1; ENSG00000214978.8.
DR   GeneID; 644070; -.
DR   KEGG; hsa:644070; -.
DR   MANE-Select; ENST00000399363.5; ENSP00000465978.1; NM_001310219.2; NP_001297148.1.
DR   UCSC; uc060bew.1; human.
DR   CTD; 644070; -.
DR   GeneCards; GSG1L2; -.
DR   HGNC; HGNC:51826; GSG1L2.
DR   HPA; ENSG00000214978; Tissue enhanced (brain).
DR   neXtProt; NX_A8MUP6; -.
DR   OpenTargets; ENSG00000214978; -.
DR   VEuPathDB; HostDB:ENSG00000214978; -.
DR   eggNOG; ENOG502QVKM; Eukaryota.
DR   GeneTree; ENSGT01050000244814; -.
DR   OMA; QHSFLEP; -.
DR   OrthoDB; 957556at2759; -.
DR   PhylomeDB; A8MUP6; -.
DR   TreeFam; TF331388; -.
DR   BioGRID-ORCS; 644070; 1 hit in 15 CRISPR screens.
DR   GenomeRNAi; 644070; -.
DR   Pharos; A8MUP6; Tdark.
DR   PRO; PR:A8MUP6; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; A8MUP6; protein.
DR   Bgee; ENSG00000214978; Expressed in anterior cingulate cortex and 10 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   InterPro; IPR012478; GSG-1.
DR   Pfam; PF07803; GSG-1; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..293
FT                   /note="Germ cell-specific gene 1-like protein 2"
FT                   /id="PRO_0000343701"
FT   TOPO_DOM        1..8
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        30..120
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        121..141
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        142..160
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        161..181
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        182..204
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        205..225
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        226..293
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   CARBOHYD        59
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        67
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   293 AA;  32443 MW;  5B379C0A0EA62815 CRC64;
     MDRAKQQQAL LLLPVCLALT FSLTAVVSSH WCEGTRRVVK PLCQDQPGGQ HCIHFKRDNS
     SNGRMDNNSQ AVLYIWELGD DKFIQRGFHV GLWQSCEESL NGEDEKCRSF RSVVPAEEQG
     VLWLSIGGEV LDIVLILTSA ILLGSRVSCR SPGFHWLRVD ALVAIFMVLA GLLGMVAHMM
     YTTIFQITVN LGPEDWKPQT WDYGWSYCLA WGSFALCLAV SVSAMSRFTA ARLEFTEKQQ
     AQNGSRHSQH SFLEPEASES IWKTGAAPCP AEQAFRNVSG HLPPGAPGKV SIC