ID   GS1_NEUCR               Reviewed;         532 AA.
AC   P38678; Q7RVC7;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Glucan synthesis regulatory protein;
DE   AltName: Full=Colonial temperature-sensitive protein 2;
GN   Name=cot-2; Synonyms=gs-1; ORFNames=B13O20.130, NCU04189;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PRELIMINARY FUNCTION.
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=7937796; DOI=10.1073/pnas.91.20.9500;
RA   Enderlin C.S., Selitrennikoff C.P.;
RT   "Cloning and characterization of a Neurospora crassa gene required for
RT   (1,3) beta-glucan synthase activity and cell wall formation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 91:9500-9504(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12655011; DOI=10.1093/nar/gkg293;
RA   Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA   Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT   "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT   genome sequence.";
RL   Nucleic Acids Res. 31:1944-1954(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Involved in the regulation of 1,3-beta-glucan synthase
CC       activity and cell-wall formation.
CC   -!- SIMILARITY: Belongs to the KNR4/SMI1 family. {ECO:0000305}.
CC   -!- CAUTION: Was originally thought to be a glucan synthase.
CC       {ECO:0000305|PubMed:7937796}.
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DR   EMBL; U09275; AAA50440.1; -; mRNA.
DR   EMBL; AL451015; CAC18203.1; -; Genomic_DNA.
DR   EMBL; CM002240; EAA31913.3; -; Genomic_DNA.
DR   PIR; T46649; T46649.
DR   RefSeq; XP_961149.3; XM_956056.3.
DR   AlphaFoldDB; P38678; -.
DR   SMR; P38678; -.
DR   STRING; 5141.EFNCRP00000003789; -.
DR   EnsemblFungi; EAA31913; EAA31913; NCU04189.
DR   GeneID; 3877315; -.
DR   KEGG; ncr:NCU04189; -.
DR   VEuPathDB; FungiDB:NCU04189; -.
DR   HOGENOM; CLU_024700_0_0_1; -.
DR   InParanoid; P38678; -.
DR   Proteomes; UP000001805; Chromosome 2, Linkage Group V.
DR   GO; GO:0032153; C:cell division site; IEA:EnsemblFungi.
DR   GO; GO:0097708; C:intracellular vesicle; IEA:EnsemblFungi.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:EnsemblFungi.
DR   GO; GO:0042546; P:cell wall biogenesis; IEA:InterPro.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0032995; P:regulation of fungal-type cell wall biogenesis; IBA:GO_Central.
DR   Gene3D; 3.40.1580.10; -; 1.
DR   InterPro; IPR009203; Knr4/Smi1.
DR   InterPro; IPR018958; Knr4/Smi1-like_dom.
DR   InterPro; IPR037883; Knr4/Smi1-like_sf.
DR   Pfam; PF09346; SMI1_KNR4; 1.
DR   PIRSF; PIRSF017023; KNR4; 1.
DR   SMART; SM00860; SMI1_KNR4; 1.
DR   SUPFAM; SSF160631; SSF160631; 1.
PE   2: Evidence at transcript level;
KW   Cell wall biogenesis/degradation; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..532
FT                   /note="Glucan synthesis regulatory protein"
FT                   /id="PRO_0000209871"
FT   REGION          374..532
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        380..408
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        474..532
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   532 AA;  58939 MW;  A36C00CA96F2F21B CRC64;
     MAGLFKDIWH AMTSYDRHAG IDSPYRTGRH VPLNRNSGLA GVTTASDSRA DINSPYLQGD
     GRGSTMSFDT AYGGRAISPM PSPANGGPYS PGLVSQRQSV HQDAFDVHSP TGEIPMQNFQ
     NGGPPPPPVA SSWEKIDRWA EENYPELFDQ LGEGCTVNDL NELEYQLDCT LPQDLRQSLQ
     IHDGQERGGL PTGIIFSSML LDCEEMVQEW ENWKTVNQEF MLDPVLVKRQ SQAFAAQASS
     SKDAPNRNQN WRQELLNKQD SVPPAAIQKA YAHPAWIPLV RDWGGNNLAV DLAPGPKGHW
     GQIILFGRDY DTKYVVARSW AHFLAMVAED LSSGRWFVDE DTNELKLREF KATRVEPSYF
     EILRWRMDQK YGRTANKRKS MAPSMASASG MRSPPTPGSP YQSPTEHNEP RGRSLHRLTG
     TSPMSSPIRP GYGKPSPLAR VAEEAPPTTS LTASNASLEA KAADNLMELN TPRTSGEHSK
     EDIKVNEDSP AKERTSEDKE KKPETEANGK ATESKGKQTT VEDAEDMKDI EI