GSAML_HUMAN
ID GSAML_HUMAN Reviewed; 135 AA.
AC Q5JQS6; B2R4Y5; B3KX46; Q5JQT3;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Germinal center-associated signaling and motility-like protein;
GN Name=GCSAML; Synonyms=C1orf150;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Cerebellum, and Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Bone marrow;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q5JQS6; Q96JC9: EAF1; NbExp=3; IntAct=EBI-17857617, EBI-769261;
CC Q5JQS6; Q8N9N8: EIF1AD; NbExp=3; IntAct=EBI-17857617, EBI-750700;
CC Q5JQS6; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-17857617, EBI-6658203;
CC Q5JQS6; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-17857617, EBI-741158;
CC Q5JQS6; O43741: PRKAB2; NbExp=3; IntAct=EBI-17857617, EBI-1053424;
CC Q5JQS6; Q96FJ0: STAMBPL1; NbExp=3; IntAct=EBI-17857617, EBI-745021;
CC Q5JQS6; Q9BZL1: UBL5; NbExp=3; IntAct=EBI-17857617, EBI-607755;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5JQS6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5JQS6-2; Sequence=VSP_026612;
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK126682; BAG54358.1; -; mRNA.
DR EMBL; AK311994; BAG34932.1; -; mRNA.
DR EMBL; AL606804; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471148; EAW77193.1; -; Genomic_DNA.
DR EMBL; BC024174; AAH24174.1; -; mRNA.
DR CCDS; CCDS1635.1; -. [Q5JQS6-1]
DR CCDS; CCDS60470.1; -. [Q5JQS6-2]
DR RefSeq; NP_001268763.1; NM_001281834.1. [Q5JQS6-2]
DR RefSeq; NP_001268764.1; NM_001281835.1. [Q5JQS6-2]
DR RefSeq; NP_001268765.1; NM_001281836.1.
DR RefSeq; NP_001268766.1; NM_001281837.1.
DR RefSeq; NP_001268782.1; NM_001281853.1. [Q5JQS6-1]
DR RefSeq; NP_660321.1; NM_145278.4. [Q5JQS6-1]
DR RefSeq; XP_016855888.1; XM_017000399.1.
DR AlphaFoldDB; Q5JQS6; -.
DR BioGRID; 127173; 12.
DR IntAct; Q5JQS6; 7.
DR STRING; 9606.ENSP00000446460; -.
DR iPTMnet; Q5JQS6; -.
DR PhosphoSitePlus; Q5JQS6; -.
DR SwissPalm; Q5JQS6; -.
DR BioMuta; GCSAML; -.
DR MassIVE; Q5JQS6; -.
DR PaxDb; Q5JQS6; -.
DR PeptideAtlas; Q5JQS6; -.
DR PRIDE; Q5JQS6; -.
DR ProteomicsDB; 63057; -. [Q5JQS6-1]
DR ProteomicsDB; 63058; -. [Q5JQS6-2]
DR Antibodypedia; 34727; 97 antibodies from 18 providers.
DR DNASU; 148823; -.
DR Ensembl; ENST00000366488.5; ENSP00000355444.4; ENSG00000169224.13. [Q5JQS6-1]
DR Ensembl; ENST00000366489.5; ENSP00000355445.1; ENSG00000169224.13. [Q5JQS6-2]
DR Ensembl; ENST00000366491.6; ENSP00000355447.2; ENSG00000169224.13. [Q5JQS6-2]
DR Ensembl; ENST00000536561.5; ENSP00000446460.2; ENSG00000169224.13. [Q5JQS6-1]
DR GeneID; 148823; -.
DR KEGG; hsa:148823; -.
DR MANE-Select; ENST00000366488.5; ENSP00000355444.4; NM_145278.5; NP_660321.1.
DR UCSC; uc001ida.6; human. [Q5JQS6-1]
DR CTD; 148823; -.
DR DisGeNET; 148823; -.
DR GeneCards; GCSAML; -.
DR HGNC; HGNC:29583; GCSAML.
DR HPA; ENSG00000169224; Tissue enhanced (brain, prostate).
DR neXtProt; NX_Q5JQS6; -.
DR OpenTargets; ENSG00000169224; -.
DR PharmGKB; PA142672467; -.
DR VEuPathDB; HostDB:ENSG00000169224; -.
DR eggNOG; ENOG502T9FX; Eukaryota.
DR GeneTree; ENSGT00940000158134; -.
DR HOGENOM; CLU_155984_0_0_1; -.
DR InParanoid; Q5JQS6; -.
DR OMA; CLRNNQK; -.
DR PhylomeDB; Q5JQS6; -.
DR TreeFam; TF338596; -.
DR PathwayCommons; Q5JQS6; -.
DR SignaLink; Q5JQS6; -.
DR BioGRID-ORCS; 148823; 17 hits in 1070 CRISPR screens.
DR ChiTaRS; GCSAML; human.
DR GenomeRNAi; 148823; -.
DR Pharos; Q5JQS6; Tdark.
DR PRO; PR:Q5JQS6; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5JQS6; protein.
DR Bgee; ENSG00000169224; Expressed in buccal mucosa cell and 97 other tissues.
DR ExpressionAtlas; Q5JQS6; baseline and differential.
DR Genevisible; Q5JQS6; HS.
DR GO; GO:0050855; P:regulation of B cell receptor signaling pathway; IEA:InterPro.
DR GO; GO:2000401; P:regulation of lymphocyte migration; IEA:InterPro.
DR InterPro; IPR031364; GC_assoc_lym.
DR PANTHER; PTHR35351; PTHR35351; 1.
DR Pfam; PF15666; HGAL; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..135
FT /note="Germinal center-associated signaling and motility-
FT like protein"
FT /id="PRO_0000294242"
FT REGION 1..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 26..50
FT /evidence="ECO:0000255"
FT COMPBIAS 13..46
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..67
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 10..29
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_026612"
SQ SEQUENCE 135 AA; 15712 MW; 51875AF9D14FBD53 CRC64;
MGNYLLRKLS CLGENQKKPK KGNPDEERKR QEMTTFERKL QDQDKKSQEV SSTSNQENEN
GSGSEEVCYT VINHIPHQRS SLSSNDDGYE NIDSLTRKVR QFRERSETEY ALLRTSVSRP
CSCTHEHDYE VVFPH
