ID   GSC2_MOUSE              Reviewed;         201 AA.
AC   P56916; A2RTU1; Q05A98;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   23-FEB-2022, sequence version 2.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Homeobox protein goosecoid-2;
DE            Short=GSC-2;
DE   AltName: Full=Homeobox protein goosecoid-like;
DE            Short=GSC-L;
GN   Name=Gsc2; Synonyms=Gscl;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9037598; DOI=10.1101/gr.7.1.17;
RA   Galili N., Baldwin H.S., Lund J., Reeves R., Gong W., Wang Z., Roe B.A.,
RA   Emanuel B.S., Nayak S., Mickanin C., Budarf M.L., Buck C.A.;
RT   "A region of mouse chromosome 16 is syntenic to the DiGeorge,
RT   velocardiofacial syndrome minimal critical region.";
RL   Genome Res. 7:17-26(1997).
RN   [2]
RP   ERRATUM OF PUBMED:9037598.
RX   PubMed=9110179;
RA   Galili N., Baldwin H.S., Lund J., Reeves R., Gong W., Wang Z., Roe B.A.,
RA   Emanuel B.S., Nayak S., Mickanin C., Budarf M.L., Buck C.A.;
RL   Genome Res. 7:399-399(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   TISSUE SPECIFICITY.
RX   PubMed=9441739; DOI=10.1006/geno.1997.5046;
RA   Funke B., St Jore B., Puech A., Sirotkin H., Edelmann L., Carlson C.,
RA   Raft S., Pandita R.K., Kucherlapati R., Skoultchi A., Morrow B.E.;
RT   "Characterization and mutation analysis of goosecoid-like (GSCL), a
RT   homeodomain-containing gene that maps to the critical region for VCFS/DGS
RT   on 22q11.";
RL   Genomics 46:364-372(1997).
CC   -!- FUNCTION: May have a role in development. May regulate its own
CC       transcription. May bind the bicoid consensus sequence TAATCC.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- TISSUE SPECIFICITY: Expressed in adult testis.
CC       {ECO:0000269|PubMed:9441739}.
CC   -!- DEVELOPMENTAL STAGE: Has a biphasic expression. Present in embryos in
CC       8.5-10.5 dpc, reduced levels in 11.5 dpc and 13.5 dpc and absent in
CC       15.5 dpc. Found in some adult tissues.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI32638.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AC003063; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC005817; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC004412; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; GL456175; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC125356; AAI25357.1; -; mRNA.
DR   EMBL; BC132637; AAI32638.2; ALT_INIT; mRNA.
DR   CCDS; CCDS49786.2; -.
DR   RefSeq; NP_083745.1; NM_029469.1.
DR   AlphaFoldDB; P56916; -.
DR   SMR; P56916; -.
DR   STRING; 10090.ENSMUSP00000012279; -.
DR   PaxDb; P56916; -.
DR   PRIDE; P56916; -.
DR   Antibodypedia; 7476; 72 antibodies from 21 providers.
DR   DNASU; 195333; -.
DR   Ensembl; ENSMUST00000012279; ENSMUSP00000012279; ENSMUSG00000022738.
DR   GeneID; 195333; -.
DR   KEGG; mmu:195333; -.
DR   UCSC; uc012aby.1; mouse.
DR   CTD; 2928; -.
DR   MGI; MGI:892006; Gsc2.
DR   VEuPathDB; HostDB:ENSMUSG00000022738; -.
DR   eggNOG; KOG0490; Eukaryota.
DR   GeneTree; ENSGT00940000162536; -.
DR   HOGENOM; CLU_122191_0_0_1; -.
DR   InParanoid; P56916; -.
DR   OMA; DTRFPWP; -.
DR   OrthoDB; 1270742at2759; -.
DR   TreeFam; TF351613; -.
DR   BioGRID-ORCS; 195333; 0 hits in 72 CRISPR screens.
DR   PRO; PR:P56916; -.
DR   Proteomes; UP000000589; Chromosome 16.
DR   RNAct; P56916; protein.
DR   Bgee; ENSMUSG00000022738; Expressed in gastrula and 42 other tissues.
DR   GO; GO:0005634; C:nucleus; IDA:MGI.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISO:MGI.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISO:MGI.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISO:MGI.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..201
FT                   /note="Homeobox protein goosecoid-2"
FT                   /id="PRO_0000048892"
FT   DNA_BIND        123..182
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..55
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          95..124
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          179..201
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   201 AA;  22022 MW;  82303BAFE9AA7723 CRC64;
     MATAGSAASR RDPGRPCPFS IEHILSSLPE RRPATRPPQP VGGRNPAELD EPEAPVPAAP
     CACCCCCNPR AATRGTPETS SGPGLRLAWP LRLAPATPSP LTAPRAGSPA LTGTSGPGPQ
     RRTRRHRTIF SEEQLQALEA LFVQNQYPDV GTRERLAVRI RLREERVEVW FKNRRAKWRH
     QKRASSSRLL PGTKKTPKES C