ID   GSCA_XENLA              Reviewed;         243 AA.
AC   P29454;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 2.
DT   25-MAY-2022, entry version 108.
DE   RecName: Full=Homeobox protein goosecoid isoform A;
GN   Name=gsc-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Gastrula;
RX   PubMed=1677215; DOI=10.1126/science.1677215;
RA   Blumberg B., Wright C.V.E., De Robertis E.M., Cho K.W.Y.;
RT   "Organizer-specific homeobox genes in Xenopus laevis embryos.";
RL   Science 253:194-196(1991).
RN   [2]
RP   FUNCTION, TISSUE SPECIFICITY, AND INDUCTION.
RX   PubMed=1684739; DOI=10.1016/0092-8674(91)90288-a;
RA   Cho K.W.Y., Blumberg B., Steinbeisser H., De Robertis E.M.;
RT   "Molecular nature of Spemann's organizer: the role of the Xenopus homeobox
RT   gene goosecoid.";
RL   Cell 67:1111-1120(1991).
RN   [3]
RP   INDUCTION.
RX   PubMed=9310324; DOI=10.1242/dev.124.17.3293;
RA   Sampath K., Cheng A.M.S., Frisch A., Wright C.V.E.;
RT   "Functional differences among Xenopus nodal-related genes in left-right
RT   axis determination.";
RL   Development 124:3293-3302(1997).
RN   [4]
RP   INDUCTION.
RX   PubMed=10068640; DOI=10.1242/dev.126.7.1467;
RA   Sun B.I., Bush S.M., Collins-Racie L.A., LaVallie E.R.,
RA   DiBlasio-Smith E.A., Wolfman N.M., McCoy J.M., Sive H.L.;
RT   "derriere: a TGF-beta family member required for posterior development in
RT   Xenopus.";
RL   Development 126:1467-1482(1999).
CC   -!- FUNCTION: Plays a central role in executing Spemann's organizer
CC       phenomenon (the dorsal blastopore lip of the early Xenopus laevis
CC       gastrula can organize a complete secondary body axis when transplanted
CC       to another embryo). {ECO:0000269|PubMed:1684739}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: At the start of gastrulation, it is found in a
CC       patch of cells encompassing 60 degrees of arc on the dorsal marginal
CC       zone. {ECO:0000269|PubMed:1684739}.
CC   -!- INDUCTION: Induced by activin (even in the absence of protein
CC       synthesis), lithium chloride, nodal/nr-1, nodal2/nr-2 and derriere. Not
CC       affected by basic fibroblast growth factor, and repressed by retinoic
CC       acid, and by UV light. {ECO:0000269|PubMed:10068640,
CC       ECO:0000269|PubMed:1684739, ECO:0000269|PubMed:9310324}.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA49744.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; M63872; AAA49744.1; ALT_INIT; mRNA.
DR   PIR; B42768; B42768.
DR   AlphaFoldDB; P29454; -.
DR   SMR; P29454; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..243
FT                   /note="Homeobox protein goosecoid isoform A"
FT                   /id="PRO_0000048889"
FT   DNA_BIND        148..207
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          201..243
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        206..243
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   243 AA;  27397 MW;  16B12AA47B0A086A CRC64;
     MPSGMFSIDN ILAARPRCKE SVLLPQNGPV VFSSLGESLY GPADYSGFYN RAVAPTSTLQ
     GVNGSRLGFN NYYYGQLHVQ THLGPSCCGT VQALGTQQCS CVPPATAYDG AGSVLMPPVP
     HQMLPYMNVG TLSRTELQLL NQLHCRRKRR HRTIFTDEQL EALENLFQET KYPDVGTREQ
     LARRVHLREE KVEVWFKNRR AKWRRQKRSS SEESENAQKW NKSSKNSAEK ADEQVKSDLD
     SDS