ID   GSC_CHICK               Reviewed;         245 AA.
AC   P53545;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Homeobox protein goosecoid;
GN   Name=GSC;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Limb bud;
RX   PubMed=7916659; DOI=10.1016/0092-8674(93)90512-o;
RA   Izpisua-Belmonte J.-C., De Robertis E.M., Storey K.G., Stern C.D.;
RT   "The homeobox gene goosecoid and the origin of organizer cells in the early
RT   chick blastoderm.";
RL   Cell 74:645-659(1993).
CC   -!- FUNCTION: Involved in the development of the organizer region in the
CC       gastrula (Hensen node in chicken).
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DEVELOPMENTAL STAGE: Is first expressed in the Koller's sickle (a
CC       crescent shaped thickening located at the edge of the posterior
CC       marginal zone), and then it is detected in Hensen node which is
CC       considered as the chick organizer. Later expression is seen in the
CC       anterior most region of the head process (cells that contribute to the
CC       prechordal plate at the midline of the pharyngeal mesendoderm).
CC   -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily.
CC       {ECO:0000305}.
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DR   EMBL; X70471; CAA49897.1; -; mRNA.
DR   PIR; A47539; A47539.
DR   RefSeq; NP_990662.1; NM_205331.1.
DR   AlphaFoldDB; P53545; -.
DR   SMR; P53545; -.
DR   STRING; 9031.ENSGALP00000017857; -.
DR   PaxDb; P53545; -.
DR   GeneID; 396273; -.
DR   KEGG; gga:396273; -.
DR   CTD; 145258; -.
DR   VEuPathDB; HostDB:geneid_396273; -.
DR   eggNOG; KOG0490; Eukaryota.
DR   InParanoid; P53545; -.
DR   OrthoDB; 1270742at2759; -.
DR   PhylomeDB; P53545; -.
DR   PRO; PR:P53545; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..245
FT                   /note="Homeobox protein goosecoid"
FT                   /id="PRO_0000048888"
FT   DNA_BIND        150..209
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          203..245
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        208..245
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   245 AA;  27269 MW;  5F32787785F7547D CRC64;
     MPASMFSIDN ILAARPRCKD SVLLPPSAPV VFPSLHGDSL YGAASDYGGF YSRAVAPGSA
     LPAVGRSRLG YNNYYYGQLH VATSPVGPSC CGAVPPLGAQ QCSCVPPAGY EGAGSVLMSP
     VPHQMLPYMN VGTLSRTELQ LLNQLHCRRK RRHRTIFTDE QLEALENLFQ ETKYPDVGTR
     EQLARKVHLR EEKVEVWFKN RRAKWRRQKR SSSEESENAQ KWNKASKTSP EKRQEDGKSD
     LDSDS