ID   GSC_DANRE               Reviewed;         240 AA.
AC   P53544;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Homeobox protein goosecoid;
DE   AltName: Full=ZGSC;
GN   Name=gsc;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Embryo;
RX   PubMed=8104775; DOI=10.1242/dev.117.4.1261;
RA   Stachel S.E., Grunwald D.J., Myers P.Z.;
RT   "Lithium perturbation and goosecoid expression identify a dorsal
RT   specification pathway in the pregastrula zebrafish.";
RL   Development 117:1261-1274(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: Maternally expressed in oocytes and after
CC       fertilization, expressed in early embryos.
CC   -!- DEVELOPMENTAL STAGE: Expression is activated at, or just after the
CC       midblastula stage, about 2 hours before the appearance of the embryonic
CC       shield. In early gastrulation, expression marks the anterior shield and
CC       by late gastrulation, expression is restricted to the rostral crescent
CC       and medial strip. Levels of GSC then decline and disappear at 12 hours
CC       post-fertilization.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L03394; AAA50028.1; -; mRNA.
DR   EMBL; L03395; AAA50030.1; -; mRNA.
DR   EMBL; BC081381; AAH81381.1; -; mRNA.
DR   RefSeq; NP_571092.1; NM_131017.1.
DR   AlphaFoldDB; P53544; -.
DR   SMR; P53544; -.
DR   STRING; 7955.ENSDARP00000076522; -.
DR   PaxDb; P53544; -.
DR   Ensembl; ENSDART00000189469; ENSDARP00000147175; ENSDARG00000111184.
DR   GeneID; 30212; -.
DR   KEGG; dre:30212; -.
DR   CTD; 145258; -.
DR   ZFIN; ZDB-GENE-980528-2060; gsc.
DR   eggNOG; KOG0490; Eukaryota.
DR   InParanoid; P53544; -.
DR   OrthoDB; 1270742at2759; -.
DR   PRO; PR:P53544; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009948; P:anterior/posterior axis specification; IDA:ZFIN.
DR   GO; GO:0007420; P:brain development; IGI:ZFIN.
DR   GO; GO:0009950; P:dorsal/ventral axis specification; IEP:ZFIN.
DR   GO; GO:0009953; P:dorsal/ventral pattern formation; IDA:ZFIN.
DR   GO; GO:0021999; P:neural plate anterior/posterior regionalization; IGI:ZFIN.
DR   GO; GO:0060234; P:neuroblast delamination; IMP:ZFIN.
DR   GO; GO:0071599; P:otic vesicle development; IMP:ZFIN.
DR   GO; GO:0010717; P:regulation of epithelial to mesenchymal transition; IMP:ZFIN.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..240
FT                   /note="Homeobox protein goosecoid"
FT                   /id="PRO_0000048887"
FT   DNA_BIND        146..205
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          199..240
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        204..240
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   240 AA;  26981 MW;  7F22CFC2390CC3C6 CRC64;
     MPAGMFSIDS ILAGRPSCKD SVLLHRNAPV VFSNLTESLY TAAGDFNGLY SHTGPPAPNL
     QSVNGRIGYN NYYYGQLHVQ GPTGPACCGA IPTLGSQQCP CIPTGYDSAG SVLISPVPHQ
     MMSYMNVGTL SRTELQLLNQ LHCRRKRRHR TIFTDEQLEA LENLFQETKY PDVGTREQLA
     RKVHLREEKV EVWFKNRRAK WRRQKRSSSE ESENSQKWNK STKTTSEKIE EGKSDVDSDS