ID   GSC_PANPA               Reviewed;         257 AA.
AC   A1YG57;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Homeobox protein goosecoid;
GN   Name=GSC;
OS   Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9597;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Nickel G.C., Tefft D.L., Trevarthen K., Funt J., Adams M.D.;
RT   "Positive selection in transcription factor genes on the human lineage.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulates chordin (CHRD). May play a role in spatial
CC       programing within discrete embryonic fields or lineage compartments
CC       during organogenesis. In concert with NKX3-2, plays a role in defining
CC       the structural components of the middle ear; required for the
CC       development of the entire tympanic ring (By similarity). Probably
CC       involved in the regulatory networks that define neural crest cell fate
CC       specification and determine mesoderm cell lineages in mammals (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily.
CC       {ECO:0000305}.
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DR   EMBL; DQ977221; ABM54282.1; -; Genomic_DNA.
DR   RefSeq; XP_003832877.1; XM_003832829.2.
DR   AlphaFoldDB; A1YG57; -.
DR   BMRB; A1YG57; -.
DR   SMR; A1YG57; -.
DR   STRING; 9597.XP_003832877.1; -.
DR   Ensembl; ENSPPAT00000058864; ENSPPAP00000035974; ENSPPAG00000040766.
DR   GeneID; 100995285; -.
DR   KEGG; pps:100995285; -.
DR   CTD; 145258; -.
DR   eggNOG; KOG0490; Eukaryota.
DR   GeneTree; ENSGT00940000160635; -.
DR   OMA; AGPPCCG; -.
DR   OrthoDB; 1270742at2759; -.
DR   Proteomes; UP000240080; Chromosome 14.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005667; C:transcription regulator complex; IEA:Ensembl.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0061629; F:RNA polymerase II-specific DNA-binding transcription factor binding; IEA:Ensembl.
DR   GO; GO:0021904; P:dorsal/ventral neural tube patterning; IEA:Ensembl.
DR   GO; GO:0048704; P:embryonic skeletal system morphogenesis; IEA:Ensembl.
DR   GO; GO:0030900; P:forebrain development; IEA:Ensembl.
DR   GO; GO:0042474; P:middle ear morphogenesis; ISS:UniProtKB.
DR   GO; GO:0048644; P:muscle organ morphogenesis; IEA:Ensembl.
DR   GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IEA:Ensembl.
DR   GO; GO:0014036; P:neural crest cell fate specification; ISS:UniProtKB.
DR   GO; GO:0023019; P:signal transduction involved in regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:Ensembl.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..257
FT                   /note="Homeobox protein goosecoid"
FT                   /id="PRO_0000285443"
FT   DNA_BIND        160..219
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          213..257
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        218..257
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   257 AA;  28110 MW;  A9586CFFE128FA1E CRC64;
     MPASMFSIDN ILAARPRCKD SVLPVAPSAA APVVFPALHG DSLYGASGGA SSDYGAFYPR
     PVAPGGAGLP AAVSGSRLGY NNYFYGQLHV QAAPVGPACC GAVPPLGAQQ CSCVPTPPGY
     EGPGSVLVSP VPHQMLPYMN VGTLSRTELQ LLNQLHCRRK RRHRTIFTDE QLEALENLFQ
     ETKYPDVGTR EQLARKVHLR EEKVEVWFKN RRAKWRRQKR SSSEESENAE KWNKTSSSKA
     SPEKREEEGK SDLDSDS