ID   GSFR1_PENAE             Reviewed;         688 AA.
AC   D7PI12;
DT   06-JUL-2016, integrated into UniProtKB/Swiss-Prot.
DT   10-AUG-2010, sequence version 1.
DT   25-MAY-2022, entry version 16.
DE   RecName: Full=Probable transcription factor gsfR1 {ECO:0000303|PubMed:20534346};
DE   AltName: Full=Griseofulvin synthesis protein R1 {ECO:0000303|PubMed:20534346};
GN   Name=gsfR1 {ECO:0000303|PubMed:20534346};
OS   Penicillium aethiopicum.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX   NCBI_TaxID=36650;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=IBT 5753;
RX   PubMed=20534346; DOI=10.1016/j.chembiol.2010.03.015;
RA   Chooi Y.H., Cacho R., Tang Y.;
RT   "Identification of the viridicatumtoxin and griseofulvin gene clusters from
RT   Penicillium aethiopicum.";
RL   Chem. Biol. 17:483-494(2010).
RN   [2]
RP   BIOTECHNOLOGY.
RX   PubMed=13577889; DOI=10.1038/182476a0;
RA   Gentles J.C.;
RT   "Experimental ringworm in guinea pigs: oral treatment with griseofulvin.";
RL   Nature 182:476-477(1958).
RN   [3]
RP   BIOTECHNOLOGY.
RX   PubMed=4583105; DOI=10.1038/244292a0;
RA   Gull K., Trinci A.P.;
RT   "Griseofulvin inhibits fungal mitosis.";
RL   Nature 244:292-294(1973).
RN   [4]
RP   FUNCTION.
RX   PubMed=23978092; DOI=10.1021/cb400541z;
RA   Cacho R.A., Chooi Y.H., Zhou H., Tang Y.;
RT   "Complexity generation in fungal polyketide biosynthesis: a spirocycle-
RT   forming P450 in the concise pathway to the antifungal drug griseofulvin.";
RL   ACS Chem. Biol. 8:2322-2330(2013).
CC   -!- FUNCTION: Probable transcription factor that regulates expression of
CC       the gene cluster that mediates the biosynthesis of Griseofulvin, an
CC       important antifungal drug that has been in use for a long time for
CC       treating dermatophyte infections (PubMed:20534346).
CC       {ECO:0000269|PubMed:20534346}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- BIOTECHNOLOGY: Griseofulvin is a spirocyclic fungal natural product
CC       used in treatment of fungal dermatophytes (PubMed:13577889,
CC       PubMed:4583105). {ECO:0000269|PubMed:13577889,
CC       ECO:0000269|PubMed:4583105}.
CC   -!- CAUTION: The Zn(2)-C6 fungal-type DNA-binding domain is highly
CC       degenerated, the transcriptional regulation activity of gsfR1 is
CC       therefore doubtful. {ECO:0000305}.
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DR   EMBL; GU574478; ADI24950.1; -; Genomic_DNA.
DR   AlphaFoldDB; D7PI12; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   SMART; SM00906; Fungal_trans; 1.
PE   1: Evidence at protein level;
KW   Nucleus; Transcription; Transcription regulation.
FT   CHAIN           1..688
FT                   /note="Probable transcription factor gsfR1"
FT                   /id="PRO_0000436727"
FT   REGION          1..95
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        22..36
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        56..70
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        71..95
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   688 AA;  75545 MW;  AB47AABE50FB5553 CRC64;
     MSDGPETAEG DTDDAVQDAA VNSRVASESS ARSQPRATVV GCLPPTPFAI HTTPAPSEHS
     KEKNVSRRLP TEKTPSRLAT PQFPPTPVSS RGSIAEPSAY PSITQALRSC LPPQKDIEIL
     LSNLSSMSIF CYKSSFKLCS SWPSEMTEEQ IPIANLLYSE THPVLLARHM LLFAVGLQHL
     SPTKAIPGLT RHHRAIMEQL ADSAIKLVNT DDVLLGTLEG LENLILESFY HIDGGNIRRA
     WITMRRAVMT AQLLGLHRPG HYRFKTVNKQ NDLDPAVMWA CIVSTEQFLC LLLGLPTSTS
     GASFTIPRAT SACVESGNLP VLIPDVVRKI IERNQTHVPQ EALDMTQKID HELLGVVKQW
     PPAFWRPLQL SGLEVDSADA FWETRRAWDH IFYYSLVNQL HLPYMLNPSH VSQKVYSRIA
     CASASREILI RQIAIRTFNP VTAGCRMGDF VALIAGMTLM LAHILSHCSK GTENLLVHQR
     VGDRATVERA LECMESMSEQ HEDILTAKCA ALLKNLLDIE AGPAEARSDD GQKDDQNVLV
     VKVPHVGAIK IARDGISITP FDTEQEQVSH DGVTIGGFGS IHVSTPHDSD RDGDHQADVV
     TPNDTASQAT TQVVRPASAR KQWRPVSQRS SGDVFTLPEE TFPDASAGME EWLFQGLDTA
     FFDVLISGAG EQPLNSTDTE GWNFVMSP