ID   GSG1L_DANRE             Reviewed;         304 AA.
AC   Q4V922;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Germ cell-specific gene 1-like protein;
DE            Short=GSG1-like protein;
GN   Name=gsg1l; ORFNames=zgc:114039;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: As a component of the AMPAR complex, modifies AMPA receptor
CC       (AMPAR) gating. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the AMPAR complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}. Synapse {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the GSG1 family. {ECO:0000305}.
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DR   EMBL; BC097105; AAH97105.1; -; mRNA.
DR   RefSeq; NP_001035065.1; NM_001039976.1.
DR   AlphaFoldDB; Q4V922; -.
DR   SMR; Q4V922; -.
DR   STRING; 7955.ENSDARP00000054407; -.
DR   PaxDb; Q4V922; -.
DR   Ensembl; ENSDART00000054408; ENSDARP00000054407; ENSDARG00000037390.
DR   GeneID; 664746; -.
DR   KEGG; dre:664746; -.
DR   CTD; 146395; -.
DR   ZFIN; ZDB-GENE-050913-27; gsg1l.
DR   eggNOG; ENOG502QRSH; Eukaryota.
DR   GeneTree; ENSGT01050000244814; -.
DR   HOGENOM; CLU_063057_0_0_1; -.
DR   InParanoid; Q4V922; -.
DR   OMA; REPWESD; -.
DR   OrthoDB; 957556at2759; -.
DR   PhylomeDB; Q4V922; -.
DR   TreeFam; TF331388; -.
DR   PRO; PR:Q4V922; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 3.
DR   Bgee; ENSDARG00000037390; Expressed in brain and 5 other tissues.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR   InterPro; IPR012478; GSG-1.
DR   Pfam; PF07803; GSG-1; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Reference proteome; Synapse; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..304
FT                   /note="Germ cell-specific gene 1-like protein"
FT                   /id="PRO_0000329465"
FT   TOPO_DOM        1..8
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        30..112
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        113..133
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        134..153
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        154..174
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        175..197
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        198..218
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        219..304
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          266..304
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        266..281
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   304 AA;  34481 MW;  24FF6C521D10AB6F CRC64;
     MKTTRKCRAL LSVGLNLLAL LFSTTAFITT YWCEGTQRVP KPNCSKDRRH NCIDYGVNET
     DPSKVHYSWE TGDDRFLFRH FHTGIWYSCE ENIHGGGEKC RSFIDLAPAS ERGVLWLSVV
     SEVLYIMLLV VGFSLMCLEL FHSSNVIDGL KLNAFAAVFT VLSGLLGMVA HMMYTQVFQI
     TVSLGPEDWR PHTWDYGWSF CMAWGSFTCC MAASVTTLNS YTKTVIEFRH KRKLFEQGLR
     EEQTFLDPET FHYFRDRSVQ SISSSVDVYP SHGSSHGNSR GKMRSPPAPV DQGDNTESLG
     EEQC