ID   GSG1_BOVIN              Reviewed;         323 AA.
AC   Q3SZT1;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   29-APR-2008, sequence version 2.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Germ cell-specific gene 1 protein;
GN   Name=GSG1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford;
RX   PubMed=19390049; DOI=10.1126/science.1169588;
RG   The bovine genome sequencing and analysis consortium;
RT   "The genome sequence of taurine cattle: a window to ruminant biology and
RT   evolution.";
RL   Science 324:522-528(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May cause the redistribution of PAPOLB from the cytosol to
CC       the endoplasmic reticulum. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with PAPOLB. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}. Note=Colocalizes with PAPOLB
CC       in the endoplasmic reticulum. {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q3SZT1-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q3SZT1-2; Sequence=VSP_032990, VSP_032991;
CC   -!- SIMILARITY: Belongs to the GSG1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI02723.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AAFC03054665; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC102722; AAI02723.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001069401.1; NM_001075933.1.
DR   RefSeq; XP_015326740.1; XM_015471254.1.
DR   AlphaFoldDB; Q3SZT1; -.
DR   SMR; Q3SZT1; -.
DR   Ensembl; ENSBTAT00000006198; ENSBTAP00000006198; ENSBTAG00000004721. [Q3SZT1-2]
DR   GeneID; 530502; -.
DR   KEGG; bta:530502; -.
DR   CTD; 83445; -.
DR   VEuPathDB; HostDB:ENSBTAG00000004721; -.
DR   GeneTree; ENSGT01050000244814; -.
DR   HOGENOM; CLU_063057_0_0_1; -.
DR   InParanoid; Q3SZT1; -.
DR   OMA; GAQITYI; -.
DR   OrthoDB; 957556at2759; -.
DR   TreeFam; TF331388; -.
DR   Proteomes; UP000009136; Chromosome 5.
DR   Bgee; ENSBTAG00000004721; Expressed in semen and 31 other tissues.
DR   ExpressionAtlas; Q3SZT1; baseline.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0070063; F:RNA polymerase binding; IEA:Ensembl.
DR   InterPro; IPR012478; GSG-1.
DR   Pfam; PF07803; GSG-1; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Endoplasmic reticulum; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..323
FT                   /note="Germ cell-specific gene 1 protein"
FT                   /id="PRO_0000329460"
FT   TRANSMEM        17..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        133..153
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        164..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        208..228
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          302..323
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1
FT                   /note="M -> MSNSSQLIQNVCLTQKM (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.2"
FT                   /id="VSP_032990"
FT   VAR_SEQ         123
FT                   /note="E -> GEKGLLEFATLQGPRHPTLRFGGKRLMEKASLSHPPLGLVAK (in
FT                   isoform 2)"
FT                   /evidence="ECO:0000303|Ref.2"
FT                   /id="VSP_032991"
FT   CONFLICT        181
FT                   /note="H -> Q (in Ref. 2; AAI02723)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   323 AA;  35634 MW;  FBC761839032E90E CRC64;
     MGLPKGFSSQ RKRLSAVLNM LSLSLSTASL LSNYWFVGTQ KVPKPLCGKG LPAKCFDVPV
     PLDGGGTNAS SPEVVHYSWE TGDDRFTFHA FRSGMWLSCA EIMEEPGERC RSFLELTPPT
     EREILWLSLG AQFAYIGLEL ISFILLLTDL LFTGNPGCSL KLSAFAAISS VLSGLLGMVG
     HMMYSQVFQA TANLGPEDWR PHAWNYGWAF YTAWVSFTCC MASAVTTFNT YTRLVLEFKC
     RHSKSFRGAP GCQPHHHQCF LQQLACTAHP GGPVTSYPQF HCQPIRSISE GVDFYSELHD
     KELQQGSSQE PETKAAGSSV EEC