GSG1_RAT
ID GSG1_RAT Reviewed; 325 AA.
AC Q6AYL2;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 2.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Germ cell-specific gene 1 protein;
GN Name=Gsg1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May cause the redistribution of PAPOLB from the cytosol to
CC the endoplasmic reticulum. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with PAPOLB. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}. Note=Colocalizes with PAPOLB
CC in the endoplasmic reticulum. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6AYL2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6AYL2-2; Sequence=VSP_033002, VSP_033003;
CC -!- SIMILARITY: Belongs to the GSG1 family. {ECO:0000305}.
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DR EMBL; AABR03032696; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC079000; AAH79000.1; -; mRNA.
DR RefSeq; NP_001013184.2; NM_001013166.1. [Q6AYL2-2]
DR RefSeq; XP_017448153.1; XM_017592664.1. [Q6AYL2-1]
DR RefSeq; XP_017448154.1; XM_017592665.1.
DR AlphaFoldDB; Q6AYL2; -.
DR SMR; Q6AYL2; -.
DR Ensembl; ENSRNOT00000011295; ENSRNOP00000011295; ENSRNOG00000008518. [Q6AYL2-2]
DR GeneID; 312793; -.
DR KEGG; rno:312793; -.
DR UCSC; RGD:1306546; rat. [Q6AYL2-1]
DR CTD; 83445; -.
DR RGD; 1306546; Gsg1.
DR VEuPathDB; HostDB:ENSRNOG00000008518; -.
DR GeneTree; ENSGT01050000244814; -.
DR HOGENOM; CLU_063057_0_0_1; -.
DR InParanoid; Q6AYL2; -.
DR OMA; GAQITYI; -.
DR OrthoDB; 957556at2759; -.
DR PhylomeDB; Q6AYL2; -.
DR TreeFam; TF331388; -.
DR PRO; PR:Q6AYL2; -.
DR Proteomes; UP000002494; Chromosome 4.
DR Bgee; ENSRNOG00000008518; Expressed in testis and 13 other tissues.
DR Genevisible; Q6AYL2; RN.
DR GO; GO:0005783; C:endoplasmic reticulum; ISO:RGD.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0070063; F:RNA polymerase binding; ISO:RGD.
DR InterPro; IPR012478; GSG-1.
DR Pfam; PF07803; GSG-1; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Endoplasmic reticulum; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..325
FT /note="Germ cell-specific gene 1 protein"
FT /id="PRO_0000329463"
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..147
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..185
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 208..228
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 306..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 307..325
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1
FT /note="M -> MSDSCQLTQNVCLTQEM (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_033002"
FT VAR_SEQ 123
FT /note="E -> GEKGLLEFATLQGSCHPTLRFGGEWLMEMASLLYLPWGPLAK (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_033003"
SQ SEQUENCE 325 AA; 36057 MW; EE683BE0F8E3F512 CRC64;
MEFQKGPSDQ RTFVSAILNM LSLGLSTASL LSSEWFVGAQ KVPKPLCGQS LAAKCFDMPM
SLDGGITNAS AQEVVQYTWE AGDDRFSFLT FRSGMWLSCE ETVEEPGEKC RRFIELTPPA
QREVLWLSLG AQTAYIGLQF ISFLLLLTDL LLTSNPGCGL KLSAFAAVSL VLSGLLGMVA
HMLYLQVFQA TANLGPEDWR PHSWNYGWAF YTAWVSFTCC MVSAVTTFNT YTRMVLEFKC
RHGTSFNTNP SCRAQHHRCF LPPLTCAVHA GEPSTSCHQH PSHPIRSVSE SIDLYSAAAL
QDKKFQQENS QELKEATESS VEEQC
