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GSIC_ECOLI
ID   GSIC_ECOLI              Reviewed;         306 AA.
AC   P75798;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 153.
DE   RecName: Full=Glutathione transport system permease protein GsiC {ECO:0000305};
GN   Name=gsiC {ECO:0000303|PubMed:16109926}; Synonyms=yliC;
GN   OrderedLocusNames=b0831, JW0815;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=8905232; DOI=10.1093/dnares/3.3.137;
RA   Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A., Ikemoto K.,
RA   Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K., Kimura S.,
RA   Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K., Mori H.,
RA   Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N., Sampei G.,
RA   Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y., Yano M.,
RA   Horiuchi T.;
RT   "A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to
RT   the 12.7-28.0 min region on the linkage map.";
RL   DNA Res. 3:137-155(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [4]
RP   FUNCTION IN GLUTATHIONE TRANSPORT, AND SUBUNIT.
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=16109926; DOI=10.1128/jb.187.17.5861-5867.2005;
RA   Suzuki H., Koyanagi T., Izuka S., Onishi A., Kumagai H.;
RT   "The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel
RT   glutathione importer with an ATP-binding cassette.";
RL   J. Bacteriol. 187:5861-5867(2005).
RN   [5]
RP   TOPOLOGY [LARGE SCALE ANALYSIS], AND SUBCELLULAR LOCATION.
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=15919996; DOI=10.1126/science.1109730;
RA   Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT   "Global topology analysis of the Escherichia coli inner membrane
RT   proteome.";
RL   Science 308:1321-1323(2005).
RN   [6]
RP   INTERACTION WITH GSIB.
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=30515393; DOI=10.1155/2018/3429569;
RA   Wang Z., Xia X., Zhang M., Fang J., Li Y., Zhang M.;
RT   "Purification and characterization of glutathione binding protein GsiB from
RT   Escherichia coli.";
RL   Biomed. Res. Int. 2018:3429569-3429569(2018).
CC   -!- FUNCTION: Part of the ABC transporter complex GsiABCD involved in
CC       glutathione import. Probably responsible for the translocation of the
CC       substrate across the membrane. {ECO:0000305|PubMed:16109926}.
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (GsiA),
CC       two transmembrane proteins (GsiC and GsiD) and a solute-binding protein
CC       (GsiB) (Probable). In the presence of glutathione, interacts with the
CC       glutathione-binding protein GsiB (PubMed:30515393).
CC       {ECO:0000269|PubMed:30515393, ECO:0000305|PubMed:16109926}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC       permease family. {ECO:0000305}.
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DR   EMBL; U00096; AAC73918.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAA35526.1; -; Genomic_DNA.
DR   PIR; G64820; G64820.
DR   RefSeq; NP_415352.1; NC_000913.3.
DR   RefSeq; WP_000936043.1; NZ_STEB01000019.1.
DR   AlphaFoldDB; P75798; -.
DR   SMR; P75798; -.
DR   BioGRID; 4259983; 14.
DR   ComplexPortal; CPX-4325; Glutathione ABC transporter complex.
DR   IntAct; P75798; 2.
DR   STRING; 511145.b0831; -.
DR   TCDB; 3.A.1.5.11; the atp-binding cassette (abc) superfamily.
DR   PaxDb; P75798; -.
DR   PRIDE; P75798; -.
DR   EnsemblBacteria; AAC73918; AAC73918; b0831.
DR   EnsemblBacteria; BAA35526; BAA35526; BAA35526.
DR   GeneID; 66670895; -.
DR   GeneID; 945460; -.
DR   KEGG; ecj:JW0815; -.
DR   KEGG; eco:b0831; -.
DR   PATRIC; fig|1411691.4.peg.1447; -.
DR   EchoBASE; EB3247; -.
DR   eggNOG; COG0601; Bacteria.
DR   HOGENOM; CLU_036879_0_0_6; -.
DR   InParanoid; P75798; -.
DR   OMA; MQEDYMR; -.
DR   PhylomeDB; P75798; -.
DR   BioCyc; EcoCyc:YLIC-MON; -.
DR   BioCyc; MetaCyc:YLIC-MON; -.
DR   BRENDA; 7.4.2.10; 2026.
DR   PRO; PR:P75798; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0055052; C:ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing; IC:ComplexPortal.
DR   GO; GO:0005887; C:integral component of plasma membrane; ISM:EcoCyc.
DR   GO; GO:0016020; C:membrane; IC:ComplexPortal.
DR   GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR   GO; GO:0034634; F:glutathione transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0034775; P:glutathione transmembrane transport; IBA:GO_Central.
DR   CDD; cd06261; TM_PBP2; 1.
DR   Gene3D; 1.10.3720.10; -; 1.
DR   InterPro; IPR045621; BPD_transp_1_N.
DR   InterPro; IPR000515; MetI-like.
DR   InterPro; IPR035906; MetI-like_sf.
DR   Pfam; PF00528; BPD_transp_1; 1.
DR   Pfam; PF19300; BPD_transp_1_N; 1.
DR   SUPFAM; SSF161098; SSF161098; 1.
DR   PROSITE; PS50928; ABC_TM1; 1.
PE   1: Evidence at protein level;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..306
FT                   /note="Glutathione transport system permease protein GsiC"
FT                   /id="PRO_0000060261"
FT   TOPO_DOM        1..8
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TOPO_DOM        30..102
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        103..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TOPO_DOM        124..134
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TOPO_DOM        156..168
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        169..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TOPO_DOM        190..228
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        229..249
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TOPO_DOM        250..277
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        278..298
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   TOPO_DOM        299..306
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000269|PubMed:15919996"
FT   DOMAIN          95..292
FT                   /note="ABC transmembrane type-1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
SQ   SEQUENCE   306 AA;  34066 MW;  B74F4D9F2527AECE CRC64;
     MLNYVIKRLL GLIPTLFIVS VLVFLFVHML PGDPARLIAG PEADAQVIEL VRQQLGLDQP
     LYHQFWHYIS NAVQGDFGLS MVSRRPVADE IASRFMPTLW LTITSMVWAV IFGMAAGIIA
     AVWRNRWPDR LSMTIAVSGI SFPAFALGML LIQVFSVELG WLPTVGADSW QHYILPSLTL
     GAAVAAVMAR FTRASFVDVL SEDYMRTARA KGVSETWVVL KHGLRNAMIP VVTMMGLQFG
     FLLGGSIVVE KVFNWPGLGR LLVDSVEMRD YPVIQAEILL FSLEFILINL VVDVLYAAIN
     PAIRYK
 
 
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