GSKIP_BOVIN
ID GSKIP_BOVIN Reviewed; 139 AA.
AC Q0P5A3;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 19-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=GSK3B-interacting protein {ECO:0000250|UniProtKB:Q9P0R6};
DE Short=GSKIP {ECO:0000250|UniProtKB:Q9P0R6};
GN Name=GSKIP {ECO:0000250|UniProtKB:Q9P0R6};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Hippocampus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: A-kinase anchoring protein for GSK3B and PKA that regulates
CC or facilitates their kinase activity towards their targets. The ternary
CC complex enhances Wnt-induced signaling by facilitating the GSK3B- and
CC PKA-induced phosphorylation of beta-catenin leading to beta-catenin
CC degradation and stabilization respectively. Upon cAMP activation, the
CC ternary complex contributes to neuroprotection against oxidative
CC stress-induced apoptosis by facilitating the PKA-induced
CC phosphorylation of DML1 and PKA-induced inactivation of GSK3B. During
CC neurite outgrowth promotes neuron proliferation; while increases beta-
CC catenin-induced transcriptional activity through GSK3B kinase activity
CC inhibition, reduces N-cadherin level to promote cell cycle progression
CC (By similarity). May play a role in cleft palate formation and is
CC required for postnatal life through modulation of the activity of GSK3B
CC during development (By similarity). {ECO:0000250|UniProtKB:Q8BGR8,
CC ECO:0000250|UniProtKB:Q9P0R6}.
CC -!- SUBUNIT: Forms a complex composed of PRKAR2A or PRKAR2B, GSK3B and
CC GSKIP through GSKIP interaction; facilitates PKA-induced
CC phosphorylation of GSK3B leading to GSK3B inactivation; recruits DNM1L
CC through GSK3B for PKA-mediated phosphorylation of DNM1L; promotes beta-
CC catenin degradation through GSK3B-induced phosphorylation of beta-
CC catenin; stabilizes beta-catenin and enhances Wnt-induced signaling
CC through PKA-induced phosphorylation of beta-catenin. Interacts with
CC GSK3B; induces GSK3B-mediated phosphorylation of GSKIP and inhibits
CC GSK3B kinase activity. {ECO:0000250|UniProtKB:Q9P0R6}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9P0R6}. Nucleus
CC {ECO:0000250|UniProtKB:Q9P0R6}.
CC -!- PTM: Phosphorylated by GSK3B. {ECO:0000250|UniProtKB:Q9P0R6}.
CC -!- SIMILARITY: Belongs to the GSKIP family. {ECO:0000305}.
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DR EMBL; BC120306; AAI20307.1; -; mRNA.
DR RefSeq; NP_001071524.1; NM_001078056.1.
DR RefSeq; XP_005222300.1; XM_005222243.3.
DR RefSeq; XP_005222301.1; XM_005222244.3.
DR AlphaFoldDB; Q0P5A3; -.
DR SMR; Q0P5A3; -.
DR STRING; 9913.ENSBTAP00000026427; -.
DR PaxDb; Q0P5A3; -.
DR Ensembl; ENSBTAT00000026427; ENSBTAP00000026427; ENSBTAG00000019836.
DR Ensembl; ENSBTAT00000067268; ENSBTAP00000071714; ENSBTAG00000019836.
DR GeneID; 616052; -.
DR KEGG; bta:616052; -.
DR CTD; 51527; -.
DR VEuPathDB; HostDB:ENSBTAG00000019836; -.
DR VGNC; VGNC:29679; GSKIP.
DR eggNOG; KOG3965; Eukaryota.
DR GeneTree; ENSGT00390000009517; -.
DR HOGENOM; CLU_143747_0_0_1; -.
DR InParanoid; Q0P5A3; -.
DR OMA; FAVTEMH; -.
DR OrthoDB; 1508955at2759; -.
DR TreeFam; TF313906; -.
DR Proteomes; UP000009136; Chromosome 21.
DR Bgee; ENSBTAG00000019836; Expressed in semen and 105 other tissues.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0019207; F:kinase regulator activity; IBA:GO_Central.
DR GO; GO:0051018; F:protein kinase A binding; IBA:GO_Central.
DR GO; GO:0034237; F:protein kinase A regulatory subunit binding; IEA:Ensembl.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0004860; F:protein kinase inhibitor activity; ISS:UniProtKB.
DR GO; GO:0008631; P:intrinsic apoptotic signaling pathway in response to oxidative stress; ISS:UniProtKB.
DR GO; GO:0006469; P:negative regulation of protein kinase activity; ISS:UniProtKB.
DR GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; ISS:UniProtKB.
DR GO; GO:0030111; P:regulation of Wnt signaling pathway; ISS:UniProtKB.
DR Gene3D; 3.30.2280.10; -; 1.
DR InterPro; IPR037395; GSKIP.
DR InterPro; IPR007967; GSKIP_dom.
DR InterPro; IPR023231; GSKIP_dom_sf.
DR PANTHER; PTHR12490; PTHR12490; 1.
DR Pfam; PF05303; DUF727; 1.
DR SUPFAM; SSF103107; SSF103107; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..139
FT /note="GSK3B-interacting protein"
FT /id="PRO_0000359874"
FT REGION 41..45
FT /note="Required for PRKAR2A interaction; contributes to a
FT protective effect against H(2)O(2)-induced apoptosis"
FT /evidence="ECO:0000250|UniProtKB:Q9P0R6"
FT REGION 115..139
FT /note="Interaction with GSK3B and acts as GSK3B inhibitor"
FT /evidence="ECO:0000250|UniProtKB:Q9P0R6"
FT SITE 130
FT /note="Required for GSK3B interaction; contributes to a
FT protective effect against H(2)O(2)-induced apoptosis"
FT /evidence="ECO:0000250|UniProtKB:Q9P0R6"
SQ SEQUENCE 139 AA; 15714 MW; 6FAFC2EBA3D99D5C CRC64;
METDCNPMEL SGVSGFEEEA ELNGFEGTDM KDMRLEAEAV VNDVLFAVNT MFVSKTLRCA
DDVAYINVET RERNRYCLEL TEAGLRVVGY AFDQVDDHLQ TPYHETVYSL LDTLSPAYRE
AFGNALLQRL EALKREGQS
