GSLG1_CAEEL
ID GSLG1_CAEEL Reviewed; 1149 AA.
AC Q19459; Q6BEU4;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Golgi apparatus protein 1 homolog;
DE Flags: Precursor;
GN ORFNames=F14E5.2;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-411, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RC STRAIN=Bristol N2;
RX PubMed=12754521; DOI=10.1038/nbt829;
RA Kaji H., Saito H., Yamauchi Y., Shinkawa T., Taoka M., Hirabayashi J.,
RA Kasai K., Takahashi N., Isobe T.;
RT "Lectin affinity capture, isotope-coded tagging and mass spectrometry to
RT identify N-linked glycoproteins.";
RL Nat. Biotechnol. 21:667-672(2003).
RN [3]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-411, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RC STRAIN=Bristol N2;
RX PubMed=17761667; DOI=10.1074/mcp.m600392-mcp200;
RA Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T.,
RA Taoka M., Takahashi N., Isobe T.;
RT "Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis
RT elegans and suggests an atypical translocation mechanism for integral
RT membrane proteins.";
RL Mol. Cell. Proteomics 6:2100-2109(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=Q19459-1; Sequence=Displayed;
CC Name=b;
CC IsoId=Q19459-2; Sequence=VSP_020297;
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DR EMBL; Z66522; CAA91405.1; -; Genomic_DNA.
DR EMBL; Z66522; CAH04737.1; -; Genomic_DNA.
DR PIR; T20891; T20891.
DR RefSeq; NP_001022087.1; NM_001026916.4. [Q19459-1]
DR RefSeq; NP_001022088.1; NM_001026917.5.
DR AlphaFoldDB; Q19459; -.
DR SMR; Q19459; -.
DR BioGRID; 39671; 6.
DR DIP; DIP-25688N; -.
DR IntAct; Q19459; 1.
DR STRING; 6239.F14E5.2a.1; -.
DR iPTMnet; Q19459; -.
DR EPD; Q19459; -.
DR PaxDb; Q19459; -.
DR PeptideAtlas; Q19459; -.
DR EnsemblMetazoa; F14E5.2a.1; F14E5.2a.1; WBGene00008800. [Q19459-1]
DR EnsemblMetazoa; F14E5.2b.1; F14E5.2b.1; WBGene00008800. [Q19459-2]
DR GeneID; 174342; -.
DR UCSC; F14E5.2b; c. elegans. [Q19459-1]
DR CTD; 174342; -.
DR WormBase; F14E5.2a; CE03205; WBGene00008800; -. [Q19459-1]
DR WormBase; F14E5.2b; CE36926; WBGene00008800; -. [Q19459-2]
DR eggNOG; KOG3648; Eukaryota.
DR GeneTree; ENSGT00390000011262; -.
DR HOGENOM; CLU_011063_0_0_1; -.
DR InParanoid; Q19459; -.
DR OMA; FTYKFKE; -.
DR OrthoDB; 189325at2759; -.
DR PhylomeDB; Q19459; -.
DR Reactome; R-CEL-202733; Cell surface interactions at the vascular wall.
DR PRO; PR:Q19459; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00008800; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0000139; C:Golgi membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0017134; F:fibroblast growth factor binding; IBA:GO_Central.
DR InterPro; IPR001893; Cys-rich_GLG1_repeat.
DR InterPro; IPR017873; Cys-rich_GLG1_repeat_euk.
DR InterPro; IPR039728; GLG1.
DR PANTHER; PTHR11884; PTHR11884; 1.
DR Pfam; PF00839; Cys_rich_FGFR; 15.
DR PROSITE; PS51289; GLG1_C_RICH; 16.
PE 1: Evidence at protein level;
KW Alternative splicing; Glycoprotein; Membrane; Reference proteome; Repeat;
KW Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..1149
FT /note="Golgi apparatus protein 1 homolog"
FT /id="PRO_0000248530"
FT TOPO_DOM 20..1115
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 1116..1136
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1137..1149
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 24..69
FT /note="Cys-rich GLG1 1"
FT REPEAT 71..135
FT /note="Cys-rich GLG1 2"
FT REPEAT 139..207
FT /note="Cys-rich GLG1 3"
FT REPEAT 216..276
FT /note="Cys-rich GLG1 4"
FT REPEAT 277..344
FT /note="Cys-rich GLG1 5"
FT REPEAT 349..411
FT /note="Cys-rich GLG1 6"
FT REPEAT 415..475
FT /note="Cys-rich GLG1 7"
FT REPEAT 477..549
FT /note="Cys-rich GLG1 8"
FT REPEAT 551..610
FT /note="Cys-rich GLG1 9"
FT REPEAT 613..676
FT /note="Cys-rich GLG1 10"
FT REPEAT 677..736
FT /note="Cys-rich GLG1 11"
FT REPEAT 743..803
FT /note="Cys-rich GLG1 12"
FT REPEAT 809..867
FT /note="Cys-rich GLG1 13"
FT REPEAT 868..938
FT /note="Cys-rich GLG1 14"
FT REPEAT 945..1009
FT /note="Cys-rich GLG1 15"
FT REPEAT 1010..1070
FT /note="Cys-rich GLG1 16"
FT CARBOHYD 133
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 411
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:12754521,
FT ECO:0000269|PubMed:17761667"
FT VAR_SEQ 762..763
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_020297"
SQ SEQUENCE 1149 AA; 131669 MW; FD81BE02572B8F79 CRC64;
MWRFPLILAS VCWLTTAQQQ NVANDPDKKL ASFDACKADI HKHCSRPDVD LTSDMSILEC
LQDAGFSETA TLSEQCEQLV WDFKVKITQD ERFVSAAKQY CEEELKGNAA MNLCTSQTQP
GFALSCLMEF TKNVTETGKC HAFLARTERL AFSDFRLVGP FVTKCRAILD KFKCNVLTPD
PAHKGVRVAH TQGMALECIL DKVVKNAKTQ ADALQILGDD CKHEVLRLAE MQADDFHLDR
PLFFACRLDR ERYCKDVPSG EGKVFECLMM NRNDKFMDPE CGNLLAERAY LMGRDYRMAH
PLTKACQPEL TRYKCEPQNQ IESAAHFHLA WILLCLENGA NQPEHKEVQP SKECAHEMIT
HRQMMMQHFR MAPELVLNCA QEIDKWCSPR GDIEAEGRTL HCLMEHAESR NETLKLGAQC
LQAVQQVVKV ADIGRNYKVD KVLYGSCRSL IDGPCAQDAV SETATLTCLM RNVDSPDMVP
ECEKRLLEVQ YFMARDWTMD PQLYEACHQE AVSRCSALDN WHQQHNSDNT VDRGPQVLAC
LYRSAYDEQN PLSVKCGTQV RQLLHVRAVR VNLIPEIEDS CREALSEFCS HNVKPSEEMM
CLQQNFETDN FKRKHPQCFA ELTKFTEMEA KDTKLNRALS KACKPVISTH CAQFANEEID
HGDVLECLVN NKDAKEMNNK CRSYVNHFEL ISLRDYHFSY KFQKACASDI EQSCKGHNND
KGEIIRCLSE VRFEHKVLGS PKDLTDDCKK QLKVAYLQQE QVEFDDKEHM ADADPKLSQK
CEQEIKMYKC NQADTFEDTI ECLRLNFEHL GPECKSMIFY REKIEAVDNS MDDELQKKCR
YDIGKFCANS DSENVLECLT NTKIVRLLQR ECKAIVKERM QESARDVRLR PQLLTSCRKE
AEQYCPEDMK KINMPQYSQT VLDGVVVSCL RDKFRQSISD QNHIDFSPRC SAEVSRAIVE
AEFDPQLDPP LYNACKSTIN DHCSATIMES GGHFDNVMEC LKNDFNKGLI RDKQCSEQVA
RRLQESLVDI HLDPVLHEAC AMDIQRYCRD VPPGHSRIVM CLMDSADKQE LSKECSTKLS
DRNKLWMKAH SEFQMALPDS WHAFANLVME HPERNSILGY LAGFIVFILL IGCCCGRVSK
KQYIEMKNR
