ID   GSM1_CANTT              Reviewed;         589 AA.
AC   C5MCK5;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Glucose starvation modulator protein 1;
GN   Name=GSM1; ORFNames=CTRG_03956;
OS   Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=294747;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-3404 / T1;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Transcription factor which regulates nonfermentable carbon
CC       utilization. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- SIMILARITY: Belongs to the ERT1/acuK family. {ECO:0000305}.
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DR   EMBL; GG692399; EER32285.1; -; Genomic_DNA.
DR   RefSeq; XP_002549659.1; XM_002549613.1.
DR   AlphaFoldDB; C5MCK5; -.
DR   STRING; 294747.C5MCK5; -.
DR   PRIDE; C5MCK5; -.
DR   EnsemblFungi; EER32285; EER32285; CTRG_03956.
DR   GeneID; 8295804; -.
DR   KEGG; ctp:CTRG_03956; -.
DR   VEuPathDB; FungiDB:CTRG_03956; -.
DR   eggNOG; ENOG502R2ZP; Eukaryota.
DR   HOGENOM; CLU_010748_2_2_1; -.
DR   OrthoDB; 681770at2759; -.
DR   Proteomes; UP000002037; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   CDD; cd00130; PAS; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR013767; PAS_fold.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF00989; PAS; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SMART; SM00091; PAS; 1.
DR   SUPFAM; SSF55785; SSF55785; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS50112; PAS; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..589
FT                   /note="Glucose starvation modulator protein 1"
FT                   /id="PRO_0000406483"
FT   DOMAIN          471..542
FT                   /note="PAS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00140"
FT   DNA_BIND        20..48
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          59..90
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          218..240
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          340..362
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        343..357
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   589 AA;  66927 MW;  1D911D15AC682CC9 CRC64;
     MTKKLTPQEK QNRKPAVRAC VFCHQKHLQC SNERPCKNCV KRNIGHECRD IVRKRVQYLT
     GNGKGSSSKT KTPRKKLKST PITASSPSVA STISPLPIDA GLKQEFSTPN EIPMSEPSLT
     NQPLSMSPLN PQGANNITNN FNSHATSQQI KEILEVPPHV NSMMNNSGLN TNVSLTPETL
     MIPDHLQFHT TTMLNTTNDV LNKLLTDQFE TESLISANNS NNTSHNDNFI AQNNNNNPEP
     SNLHNRHQFS SNYLNEEYLM LGDILLHSKP VSPSPSNTSA SEYNTNTLSP TNFGFIQNID
     FEGFNQPKKK VAKKLKESRP FISLGYTDDS TLRLNHAPEA NGQTEDLLDH NKDDSRKNPG
     NGNSIINFET KYVKDYVAPF ITNGLYQSVK DIYSYQIINY EYPDSYHALT KFLKERFGGN
     DLSIDERKEK RSKLLVILKL IASYRPTFIA AHKSLLKPQD LLFLEMSLQR SLLDYKKLVE
     LSSSPSIMWR RTGEIIYITE EMGLLLGYSP IEILEKRFFL FSLMPDEEII RYFKFFKNIA
     VNDLQSSISI KVKLINKEGR LVEFCSVYTI KRDIFDIPML IVGQFLPVM